Recent advances, challenges and updates on the development of therapeutics for malariaReview Article Published on 2024-05-062024-09-05 Journal: EXCLI Journal [Category] update2024, [키워드] Antimalarials artefenomel Cipargamin clinical trials malaria tafenoquine [DOI] 10.17179/excli2023-6856 PMC 바로가기 [Article Type] Review Article
Assessment In Vitro of the Antimalarial and Transmission-Blocking Activities of Cipargamin and Ganaplacide in Artemisinin-Resistant Plasmodium falciparumArticle Published on 2022-03-152024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Cipargamin Gametocytes ganaplacide Plasmodium falciparum transmission-blocking activity.
Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa성인 Plasmodium falciparum 말라리아 환자에서 cipargamin (KAE609)의 간 안전성 및 내약성: 사하라 이남 아프리카에서의 무작위, 2상, 대조, 용량 증량 시험Research Published on 2021-12-202024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] Cipargamin Hepatic safety KAE609 malaria Phase II randomized controlled trial Plasmodium falciparum [DOI] 10.1186/s12936-021-04009-1 PMC 바로가기 [Article Type] Research
Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum IsolatesArticle Published on 2021-09-172024-08-28 Journal: Med Instrum [Category] 말라리아, [키워드] Cipargamin drug resistance KAE609 malaria PA92 PfATP4 Plasmodium falciparum SJ733 Uganda
Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranesArticle Published on 2018-08-242024-08-28 Journal: Brain stimulation [Category] 말라리아, [키워드] antiplasmodial drug ATPase Cipargamin drug action drug resistance malaria membrane transport PfATP4 Plasmodium falciparum sodium transporter.
Spiroindolone NITD609 is a novel antimalarial drug that targets the P-type ATPase PfATP4article Published on 2016-12-312024-09-01 Journal: Future Med Chem [Category] 말라리아, [키워드] Cipargamin KAE609 malaria NIDT609 PfATP4 Plasmodium Spiroindolone [Article Type] article
Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium falciparum Malaria복잡하지 않은 플라스모디움 팔시파룸 말라리아에서 시파르가민의 생체 내 MIC 추정Article Published on 2016-11-212024-08-12 Journal: Med Instrum [Category] 말라리아, [키워드] Cipargamin clinical trial malaria pharmacokinetic-pharmacodynamic model resistance [DOI] 10.1128/AAC.01940-16 PMC 바로가기
The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugsArticle Published on 2015-08-272024-08-29 Journal: International Journal for Parasitology: Drugs and Drug Resistance [Category] 말라리아, [키워드] antimalarial Cipargamin Drug discovery PfATP4 Plasmodium Resistance selection.