circulating leukocytes – Communicable Diseases Research

SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients

SARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다

Article

Published on 2022-08-172022-09-11
Journal: Journal of Molecular Cell Biology [Category] SARS, 진단, 치료기술, 치료법,

[키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood Peripheral blood mononuclear cell (PBMC) Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread
[DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article

Nafamostat reduces systemic inflammation in TLR7-mediated virus-like illness

Research

Published on 2022-01-062022-10-30
Journal: Journal of Neuroinflammation [Category] COVID-19,

[키워드] addition administration Analysis animal model anti-inflammatory actions anti-inflammatory effect Anti-viral behavioural Blood Brain circulating leukocytes CNS collected COVID-19 CXCL1 CXCL10 cytokine production DMSO evaluated evidenced examined Exogenous expression had no host response IFN-γ immunohistochemistry immunomodulatory effects increased expression induce Inflammation Inflammatory response inhibit inhibiting injection Intravenous injection liver lung marker mice nafamostat pathology phenotype provide qPCR reduce reducing restored Result robust serine protease inhibitor shown Sickness Sickness behaviour significantly ssRNA suppressed systemic inflammation temperature TLR7/8 TMPRSS2 TNF Treatment treatment for COVID-19 turn viral cell viral infection virus virus infection was determined
[DOI] 10.1186/s12974-021-02357-y PMC 바로가기 [Article Type] Research

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

I형 인터페론 자가항체는 COVID-19 환자의 전신 면역 변화와 관련이 있습니다

Research Article

Published on 2021-09-222022-09-10
Journal: Science Translational Medicine [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibodies autoantibodies autoantibody caused change circulating leukocyte circulating leukocytes Control coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 Critical Critical disease dendritic cell description diagnosed disease course disease pathogenesis Effect elevated epitope evaluated Evidence evidence of expressed expression functional healthy controls help IFNs immune immune system Immunoglobulin in some increased expression individual individuals with COVID-19 inhibitory receptor interferon interferon response interferons ISG lack LAIR1 leukocyte leukocytes longitudinal mechanisms moderate disease monocyte Monocytes mononuclear cell mononuclear cells myeloid cell myeloid cells Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells peripheral blood samples Population Prevalence producing receptor reduced respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases severe disease severity single-cell Single-cell transcriptomics subset Support systemic impact systemic impacts the disease Transcriptome transcriptome sequencing transcriptomics turn Type type I Type I IFN type I interferon type I interferons
[DOI] 10.1126/scitranslmed.abh2624 PMC 바로가기 [Article Type] Research Article

Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality

독특한 염증 프로파일은 더 높은 SARS-CoV-2 급성 호흡 곤란 증후군(ARDS) 사망률과 관련이 있습니다.

Article

Published on 2021-03-012022-09-12
Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology [Category] MERS, SARS, 진단,

Feline Infectious Peritonitis as a Systemic Inflammatory Disease: Contribution of Liver and Heart to the Pathogenesis

Article

Published on 2019-12-102022-10-28
Journal: Viruses [Category] Coronavirus, MERS,