SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Structural similarity-based prediction of host factors associated with SARS-CoV-2 infection and pathogenesisSARS-CoV-2 감염 및 발병과 관련된 숙주 인자의 구조적 유사성 기반 예측Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] Analysis Apoptosis axon guidance CASP3 CD4 CD4 degradation clathrin Clathrin-mediated endocytosis clathrin-mediated endocytosis. composed Degradation down-regulate eIF2a Endoplasmic reticulum endosome enriched pathway enrichment analysis ERGIC event Factor Factors Genome heme HOPS complex Host information inhibitor interferon IRF1 life cycle matrix protein mechanism medical intervention membrane occur organized pandemic Pathogenesis phosphorylate predicted proteasomal degradation Protein protein kinase protein-protein interaction public health replicate reveal RNA synthesis SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling similarity T cell therapeutic intervention TP53 translational Transport UBA52 UBC Vesicle viral entry viral pathogenesis Viral protein virion assembly Virus life cycle [DOI] 10.1080/07391102.2021.1874532 PMC 바로가기 [Article Type] Article
Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cellsSARS-CoV-2의 숙주 세포 내로의 PI4KB 의존성 세포내이입 진입에는 ACE2의 세포질 도메인 및 효소 활성이 필요하지 않습니다Article Published on 2022-06-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) catalytic activity causative agent Cell cellular cellular entry cellular receptor clathrin Clathrin-mediated endocytosis COVID-19 pandemic delta variant demonstrated dependent on domain effective endocytosis entry of SARS-CoV-2 enzymatic activity enzyme health emergency host cell host cells human angiotensin converting enzyme 2 infections intracellular domain lentivirus Phosphoinositides PI4KB predominant principle pseudotype required SARS-CoV-2 Spike protein syncytium syncytium formation treat variant viral entry virus entry [DOI] 10.1016/j.virs.2022.03.003 PMC 바로가기 [Article Type] Article
SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cellsArticle Published on 2021-12-142022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral binding Cell Clathrin-mediated endocytosis coronavirus Coronavirus infection decrease facilitate Glutamate identify infect cell interact involved knockdown Lungs Mechanisms of disease mice Middle East Molecular biology nasal turbinate receptor reduced respiratory syndrome coronavirus SARS-CoV spike protein SARS-CoV-2 SARS-COV-2 infection significantly Spike protein the SARS-CoV-2 viral infection [DOI] 10.1038/s41421-021-00357-z PMC 바로가기 [Article Type] Article
SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain SignalingArticle Published on 2021-07-172022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 ACE2 internalization acute respiratory syndrome angiotensin-converting enzyme 2 BHK21 bind binding bioinformatics Cell cells cellular Clathrin-mediated endocytosis conserved coronavirus coronavirus entry CoV cytoplasmic cytoplasmic tail deleted demonstrated Dipeptidyl peptidase 4 domain eight Endosomal acidification HEK293T Host host cell host cells independent of Infection inhibited inhibitor motif pathway phosphorylation sites pseudotyped RBD receptor SARS-CoV SARS-CoV antibody SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Signaling significantly spike glycoprotein Spike protein Transmission Treatment understanding viral pathogenesis virus infection [DOI] 10.3390/cells10071814 PMC 바로가기 [Article Type] Article
Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors산성화 억제제에 의한 이중 억제 메커니즘을 사용하여 SARS-CoV-2 진입 및 감염을 표적으로 하는 전략Research Article Published on 2021-07-122022-09-10 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 Acidic Affect Alter Antiviral effect applicability assist attenuate Cell cells cellular mechanism cellular mechanisms Chloroquine clathrin Clathrin-mediated endocytosis Clinical management drug ectopic expression endocytic Endocytic pathway endosomal Endosomal acidification endosomal pH expressing expression FDA-approved drug FDA-approved drugs Host host cell host cells human cells Infection inhibit inhibitor mechanism neutralize niclosamide observation pathway Prevent RBD Receptor binding domain reduce SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein screened Spike protein Strategy subset Therapeutic strategies tracing undetectable Vero Cell Vero cells Viral viral entry viral infections virus viruses [DOI] 10.1371/journal.ppat.1009706 PMC 바로가기 [Article Type] Research Article
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cellArticle Published on 2021-06-232023-06-15 Journal: Cell Reports [Category] MERS, SARS, [키워드] ACE2-independent Clathrin-mediated endocytosis COVID-19 heparan sulfate proteomics RIG-I-like receptors SARS-CoV-2 spike variants type I interferon Virus-host interactions [DOI] 10.1016/j.celrep.2021.109364 PMC 바로가기 [Article Type] Article
Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus TrackingResearch Article Published on 2021-03-302022-10-29 Journal: mBio [Category] Coronavirus, [키워드] average caused caveolae Cell cell membrane clathrin Clathrin-mediated endocytosis complex coronavirus Course CoV CoV infection CoVs Dissection dynamic Endocytic pathway endocytosis endosome endosome trafficking Endosomes epidemic diarrhea Epidemics Evidence exhibiting expand Human Infection late endosome late endosomes mechanism Mediated occurred Pathways PEDV penetrate Penetrating plasma membrane porcine epidemic diarrhea coronavirus recruitment severe disease single-virus tracking Structure structures Transport undergo viral fusion viruses [DOI] 10.1128/mBio.00256-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosisResearch Article Published on 2021-01-192022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome block Cell CHC, clathrin heavy chain clathrin Clathrin-mediated endocytosis coronavirus COVID-19 CQ, Chloroquine Critical cytosol dynamin endocytic mechanism endocytosis infect Infection infection mechanism infection process knockdown lentivirus MERS-CoV, Middle-East respiratory syndrome coronavirus occur other coronaviruses plasma membrane pseudotyped purified reduce required SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus spike glycoprotein Tf, transferrin TfR, Tf receptor transfer viral entry viral infectivity Viral RNA virus entry virus infectivity [DOI] 10.1016/j.jbc.2021.100306 PMC 바로가기 [Article Type] Research Article
The Large Action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19Pharmacology Published on 2020-12-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action activity acute respiratory syndrome addition anti-SARS-CoV-2 activities Antipsychotics Antiviral antiviral activity antiviral medication antiviral properties Care caused Cell cell entry chlorpromazine clathrin Clathrin-mediated endocytosis clinical trial clinical trials coronavirus Coronavirus disease 2019 Course COVID-19 COVID-19 patient CPZ Critical defined described dosage drug early stage Efficacy evaluated event face good quality Health Human Infection information Interaction Largactil maintain mechanism of action medication Neuropsychiatric pandemic phenothiazine professional provided psychiatrist psychiatry psychotropic drug regimen Research protocol SARS-CoV-2 second wave Side effects Spread treat Treatment viral entry virus [DOI] 10.3389/fphar.2020.577678 PMC 바로가기 [Article Type] Pharmacology