A Chymotrypsin-Dependent Live-Attenuated Influenza Vaccine Provides Protective Immunity against Homologous and Heterologous VirusesArticle Published on 2024-05-082024-09-05 Journal: Vaccines [Category] update2024, [키워드] Broad-spectrum protection cleavage site Influenza live-attenuated vaccine Mucosal immunology [DOI] 10.3390/vaccines12050512 PMC 바로가기 [Article Type] Article
Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approachesArticle Published on 2022-11-012022-11-15 Journal: Chemico-biological interactions [Category] SARS, 치료제, [키워드] 3D structure ACE2 addition antiparasitic approach binding binding energy caused cleavage site COVID-19 Diminazene aceturate disease drug enzyme evaluate experimental model in silico in vitro in vivo inhibit Interaction M pro membrane molecular molecular docking molecular target Prevent processed promote protease Protein Protein Data Bank PyMol reduction in S1 and S2 SARS-CoV-2 SARS-CoV-2 protease spike receptor-binding domain stability targets tested viral replication virus infection was used [DOI] 10.1016/j.cbi.2022.110161 PMC 바로가기
The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 VariantsArticle Published on 2022-10-122022-11-16 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition association carried Cell cleavage cleavage site cleaved coronavirus D614G D614G mutation Delta dependent on epistasis epistatic interaction evaluate expressing expression increasingly Mutation omicron pandemic pathogenic Potential Protein proteolytic proteolytic cleavage pseudovirions pseudovirus pseudoviruses remained resulting S1 subunit S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 variant Site spike spike mutation spikes Spread stabilizing effect successive wave Transmissibility variant variants variants of concern Viral particles viral spike viral variant virions wild-type Wuhan [DOI] 10.1128/jvi.01301-22 PMC 바로가기
Effects of a Shift of the Signal Peptide Cleavage Site in Signal Peptide Variant on the Synthesis and Secretion of SARS-CoV-2 Spike ProteinArticle Published on 2022-10-082022-11-16 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] caused changed cleavage site COVID-19 COVID-19 pandemic demonstrated drug Effect evaluate the effect Host I13 Infection investigated mutant mutants Mutation N-terminal Pathways Protein RBD RBD protein SARS-CoV-2 SARS-CoV-2 spike protein secretion shift signal signal peptide significantly Site spike Spike protein synthesis the SARS-CoV-2 the signal peptide the spike protein treat wild type [DOI] 10.3390/molecules27196688 PMC 바로가기
Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variantsArticle Published on 2022-09-262022-11-15 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Affinity maturation Analysis antibody Antibody Response Antigen antigens caused cleavage site Combination coronavirus determine Evolution fusion peptide immunization immunogen Infection Mutation outbreak predict promote PROTECT RBD expression SARS-CoV-2 variant sequence spike Strains Structure targets the antibody response Vaccine variant variants virus wildtype Zoonotic coronavirus [DOI] 10.1371/journal.pcbi.1010563 PMC 바로가기
Evidence for Different Virulence Determinants and Host Response after Infection of Turkeys and Chickens with Highly Pathogenic H7N1 Avian Influenza VirusArticle Published on 2022-09-142023-06-22 Journal: Journal of Virology [Category] 조류인플루엔자, [키워드] Avian influenza virus chickens cleavage site glycosylation H7N1 high pathogenicity host response Transcriptome Turkeys virulence determinants [DOI] 10.1128/jvi.00994-22 PMC 바로가기
Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1Article Published on 2022-09-082022-11-16 Journal: Molecules [Category] SARS, 변종, [키워드] accompanied Activation amino acid substitution BA.2.12.1 binding cathepsin G Cell cleavage site cleaved complex COVID-19 digested End furin immune response Infection MHC modify neutrophil Neutrophil elastase Neutrophils novel omicron Omicron variant Pathogens peptide polybasic Prevalence priming protease Protein proteinase proteinase 3 S1/S2 S2 antigen S2 subunit SARS-CoV-2 SARS-CoV-2 variant secrete sequence serine protease serine proteases Site Support T cell activation the major histocompatibility the S protein the Spike TMPRSS2 viral entry [DOI] 10.3390/molecules27185817 PMC 바로가기
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturationArticle Published on 2022-09-032022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] Analysis Antiviral binding C-terminal C-terminally capture catalytic cause cleavage cleavage site cleavage sites Complete complex coronavirus 2 COVID-19 enzyme event form Interaction M pro maturation mutant non-structural protein pathogen plasticity polyprotein polyproteins Prevent protease provide representing respiratory responsible SARS-CoV-2 specificity substrates the SARS-CoV-2 therapeutic unique X-ray X-ray crystallographic structure [DOI] 10.1038/s41467-022-32854-4 PMC 바로가기
Cleavage-Responsive Biofactory T Cells Suppress Infectious Diseases-Associated HypercytokinemiaArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] 바이오마커, [키워드] activate administration Alpha Blood chimeric cleavage cleavage site coronavirus disease COVID-19 digestion Diseases domain drug endothelial engineered blood vessel engineered T cell enzyme EPCR Express expressing hypercytokinemia immune cells in vivo induce Infectious disease lentiviral system lung tissue multiple organ failure Necrosis overcome peptide Prevent Protein receptor Release Sepsis suppress T cell therapeutic thrombin receptor TRAP Treatment Vascular damage vessel [DOI] 10.1002/advs.202201883 PMC 바로가기
Broadly neutralizing antibodies target the coronavirus fusion peptide광범위 중화 항체는 코로나바이러스 융합 펩티드를 표적으로 한다Article Published on 2022-08-122022-09-12 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha antibodies antibody approach arginine residue betacoronaviruses caused cleavage site conserved coronavirus coronavirus vaccine Coronaviruses crystal structure disease epitope fusion peptide helical structure highlight identify include monoclonal antibody neutralize neutralizing antibody omicron outbreak Pathogens Receptor binding SARS-CoV-2 Seven Spike protein the SARS-CoV-2 [DOI] 10.1126/science.abq3773 PMC 바로가기 [Article Type] Article