Synthesis of Fluorinated Nucleosides/Nucleotides and Their Antiviral PropertiesReview Published on 2024-05-192024-09-05 Journal: Molecules [Category] update2024, [키워드] Antiviral carbocyclic ring clinical development clinical trials fluorinated sugar fluoro-nucleosides/nucleotides nucleosides nucleotides ribose sugar [DOI] 10.3390/molecules29102390 PMC 바로가기 [Article Type] Review
Antimicrobial Peptides towards Clinical Application—A Long History to Be ConcludedReview Published on 2024-04-292024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] antimicrobial peptides antimicrobial resistance chemical modifications clinical development preclinical development Toxicity [DOI] 10.3390/ijms25094870 PMC 바로가기 [Article Type] Review
Antimicrobial resistance crisis: could artificial intelligence be the solution?Review Published on 2024-01-232024-09-05 Journal: Mil Med Res [Category] update2024, [키워드] antibiotic antibiotic stewardship antimicrobial peptide Artificial intelligence (AI) clinical development machine learning (ML) phage therapy [DOI] 10.1186/s40779-024-00510-1 PMC 바로가기 [Article Type] Review
Vaccine value profile for enterotoxigenic Escherichia coli (ETEC)장독소형 대장균(ETEC) 백신 가치 프로필Article Published on 2023-11-302024-08-22 Journal: Vaccine [Category] 세균성이질, [키워드] clinical development Clinical research Epidemiology ETEC LMIC Vaccine Vaccine Value. [DOI] 10.1016/j.vaccine.2023.02.011
A Tutorial on Modern Bayesian Methods in Clinical TrialsEducational Review Published on 2023-04-202024-09-05 Journal: Therapeutic innovation & regulatory science [Category] update2024, [키워드] Bayesian methods bayesian statistics clinical development clinical trials Drug development [DOI] 10.1007/s43441-023-00515-3 PMC 바로가기 [Article Type] Educational Review
Herbal supplements as treatment options for COVID-19: A call for clinical development of herbal supplements for emerging and re-emerging viral threats in Sub-Saharan AfricaArticle Published on 2023-03-052024-09-05 Journal: Scientific African [Category] update2024, [키워드] clinical development COVID-19 herbal medicine Herbal Products herbal supplements SARS-CoV-2 [DOI] 10.1016/j.sciaf.2023.e01627 PMC 바로가기 [Article Type] Article
India and the COVID-19 vaccine인도와 코로나19 백신Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] approval candidate clinical development country COVID-19 vaccine COVID-19 vaccines Critical declined distribution Emergency use ENhance Health Organization highlight India lack Participation provoking public trust Regulatory regulatory system. reported Research SARS-CoV-2 stature thought Vaccine World Health Organization [DOI] 10.1080/21645515.2022.2033541 PMC 바로가기 [Article Type] Article
Efficacy of ensitrelvir against SARS-CoV-2 in a delayed-treatment mouse modelArticle Published on 2022-10-282022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] acute respiratory syndrome Administered age anti-SARS-CoV-2 Antiviral Antiviral compound antiviral efficacy body weight Body weight loss caused Cell clinical development coronavirus coronavirus disease correlated COVID-19 demonstrated development dose dose-dependent manner effective Efficacy evaluated expression general treatment Health in vivo increased survival Inflammatory Intervention lung Lung inflammation Lung pathology mice mouse-adapted SARS-CoV-2 nucleocapsid protein pandemic patients with COVID-19 Post-infection protease pulmonary lesion quantified reduced reduced viral load RNA RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection Support suppressed survival target the SARS-CoV-2 titre treat Treatment Viral RNA was used were infected [DOI] 10.1093/jac/dkac257 PMC 바로가기
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 InfectionArticle Published on 2022-09-262022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료제, [키워드] addition amplification analyzed anti-RBD antibody Antiviral antiviral strategy. assays Cell chicken clinical development cytokine domain Egg ELISA examined expression of SARS-CoV-2 Gene Expression golden hamster Host IgY immune immunization immunized immunoblot in vitro in vivo interval layer lung management monoclonal antibody neutralization capacity neutralized neutralizing antibody outbreak Outbreaks polyclonal Potential prevention purified qRT-PCR RBD SARS-CoV-2 SARS-COV-2 infection Syrian golden hamster target the S protein VERO-E6 Vero-E6 cell viability viral outbreak viral RBD Viral RNA virus virus variant viruses was measured yolk [DOI] 10.3390/v14102121 PMC 바로가기
Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding AffinityArticle Published on 2022-09-202022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome adopted affinity Analysis anti-SARS-CoV-2 anti-viral activity approved binding affinity binding free energy ChEMBL Chemistry clinical development Compound coronavirus coronavirus disease COVID-19 Cryo-electron microscopy cryo-EM cryo-EM structure database docking drug drug candidates drug library drug repositioning drugs dsRNA fragment molecular orbital calculation Frequency frequency analysis interactions mode molecular Novel coronavirus ONIOM geometry optimization calculation pathogenic PDB performed predicted quantum quantum chemistry calculation RdRP reported reproduction RNA RNA-dependent RNA polymerase SARS-CoV-2 Screening screenings significantly suggested Treatment Virtual screening was performed [DOI] 10.3390/ijms231911009 PMC 바로가기