Immunogenicity, Safety, and Anti-Viral Efficacy of a Subunit SARS-CoV-2 Vaccine Candidate in Captive Black-Footed Ferrets ( Mustela nigripes) and Their Susceptibility to Viral ChallengeArticle Published on 2022-10-042022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Affect Anti-viral Antibody Response Antibody titer black-footed ferrets candidate challenge clinical disease correlated declined Efficacy experimental challenge ferret highest Human immunogenicity in vitro in vivo increase in indicate lack lung viral load mice morbidity Mortality mustelids pathogen populations potential risk pre-vaccination produced Protein purified Safety SARS-CoV-2 SARS-CoV-2 S1 serum subunit susceptibility transfer Trial unlikely upper respiratory tract vaccination vaccinees viral replication was determined [DOI] 10.3390/v14102188 PMC 바로가기
Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgA1 antibody associated with mRNA COVID-19 vaccination: a case reportArticle Published on 2022-10-012022-11-15 Journal: The Journal of international medical research [Category] 진단, [키워드] Activation Acute kidney injury Admission antibody Case report characterized clinical disease COVID-19 COVID-19 vaccination dialysis elevated Encephalopathy exacerbating first dose galactose-deficient IgA1 Haemodialysis IgA nephropathy immunoglobulin A immunoglobulin A nephropathy. Immunosuppressive treatment kidney male Mental Mild MOST mRNA mRNA-1273 COVID-19 vaccine nephropathy Patient plasma receive receiving renal biopsy renal function reported Treatment vaccination with COVID-19 [DOI] 10.1177/03000605221129674 PMC 바로가기
CGRP Plasma Levels Correlate with the Clinical Evolution and Prognosis of Hospitalized Acute COVID-19 PatientsArticle Published on 2022-09-262022-11-15 Journal: Viruses [Category] SARS, 바이오마커, [키워드] baseline Biomarker blood sample calcitonin calcitonin gene-related peptide (CGRP) clinical clinical disease Coagulopathy collected correlated correlation COVID-19 Critical diagnosed disease disease severity eligible etiological agent Evolution heterogenous higher risk highlighting Hospitalization Hospitalized hyperinflammation immune modulation In-hospital investigated involved IP10 Italian Laboratory test Level lung majority moderate pandemic pathophysiology Patient peptide performed plasma predicted prospective cohort study pulmonary intravascular coagulopathy. SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 patients severe respiratory failure Stratification Support Vasoactive [DOI] 10.3390/v14102123 PMC 바로가기
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesisArticle Published on 2022-09-132022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] accessory gene Accessory genes accessory protein acute respiratory syndrome Affect Alter both virus cells characterized clinical disease clone contribute coronavirus COVID-19 pandemic Deletion driven by Effect ENhance evade Genome Host in vitro in vivo innate immune mouse Mutation pandemic Pathogenesis persists Protein public health crisis Receptor binding replaced Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 variant shown Signaling spike mutation Spread the spike protein Transmission Vaccine vaccine responses variant variant spike Viral variants virus viruses [DOI] 10.1073/pnas.2204717119 PMC 바로가기
Experimental Infection of Brazilian Free-Tailed Bats ( Tadarida brasiliensis) with Two Strains of SARS-CoV-2두 가지 SARS-CoV-2 균주를 사용한 브라질자유꼬리박쥐(Tadarida brasiliensis)의 실험적 감염Article Published on 2022-08-182022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus analyzed antibody production bat bat coronaviruses bats Brazilian free-tailed bat clinical disease conservation contribute coronavirus days post-infection delta variant Determining evaluated histopathological homology Infection Infectious virus lesion lung Lungs management Neutralizing antibody response North oral swabs parental pathology public health SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 strain susceptibility Tadarida Tadarida brasiliensis Transmission unlikely Viral RNA viral shedding wildlife with infection [DOI] 10.3390/v14081809 PMC 바로가기 [Article Type] Article
Biologicals decrease psychological distress, anxiety and depression in severe asthma, despite Covid-19 pandemicArticle Published on 2022-08-012022-11-15 Journal: Respiratory medicine [Category] COVID19(2023년), SARS, 진단, [키워드] addition Affect Anxiety Asthma asthma patient Asthmatic patients benralizumab biologic Biological biological drug clinical disease Comorbidity decrease Depression depressive symptom disease drug evaluate female General population HADS Hypothesis independent males management Mental disorder mepolizumab monoclonal antibodies omalizumab pandemic parameters Patient patients treated Perceived stress Prevalence previous study problem PSS Psychiatric psychiatric disorder Psychological psychological disorders Psychological distress Quality of life reported Respiratory disease risk SARS-CoV-2 SARS-CoV-2 pandemic Severe asthma Stress treated Treatment [DOI] 10.1016/j.rmed.2022.106916 PMC 바로가기
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators뉴로필린(NRP) 관련 병리학적 상태 및 조절인자Review Published on 2022-07-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition Analysis antagonists Cancer clinical disease Community computer-aided drug design condition COVID-19 COVID-19 research Diversity foci form homologous human body in silico in silico drug design joint Last Ligand ligands modulator neuropathic neuropathic pain neuropilin neuropilins NRP1 Pain pathological pathological conditions pathological role peptidomimetics physiological receptor receptor modulator design small molecule small-molecule antagonists. splice the SARS-CoV-2 therapeutic tissue transmembrane glycoprotein variant variety vertebrates viral entry [DOI] 10.3390/ijms23158402 PMC 바로가기 [Article Type] Review
Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr VirusEpstein-Barr 바이러스에 대한 양성 결과로 류마티스 관절염의 SARS-CoV-2 백신 접종 관련 활성화의 성공적인 치료Case Reports Published on 2022-07-012022-09-12 Journal: Internal medicine (Tokyo, Japan) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome administration Antigen clinical disease coronavirus COVID-19 Disease activity EBV Epstein-Barr virus Fever finding IgG introduced joint polyarthritis Protein Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccination Tocilizumab treat Vaccine virus [DOI] 10.2169/internalmedicine.9433-22 PMC 바로가기 [Article Type] Case Reports
The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
Molecular Epidemiology of AY.28 and AY.104 Delta Sub-lineages in Sri Lanka스리랑카에서 AY.28 및 AY.104 델타 하위 계통의 분자 역학Article Published on 2022-06-212022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V absence Analysis analyzed AY.104 AY.28 B.1.617.2 characterized clinical disease clinical implication clinical implications COVID-19 Delta delta variant determine dominant variant duration of hospitalization Epidemiology expression expression level genomic Illumina individual Infection investigated Laboratory Lineage lineages Mutation no difference ORF1a ORF3 ORF3a ORF6 outbreak Oxford parental periscope Prevalence RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequenced Seven severe disease severity sgRNA significantly higher Spike protein sub genomic RNA sub lineages. the spike protein variant [DOI] 10.3389/fpubh.2022.873633 PMC 바로가기 [Article Type] Article