Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
Current evidence on the use of anakinra in COVID-19Review article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 임상, 진단, 치료제, [키워드] acute respiratory distress syndrome administration Anakinra approval clinical evidence clinical status COVID-19 COVID-19 patient COVID-19 patients current cytokine cytokine release Cytokine release syndrome Cytokine storm dose early stage effective Evidence IL-1 IL-1 receptor antagonist Immunomodulatory agent include inhibit interleukin-1 intravenous knowledge management mechanical ventilation multiple organ failure off-label Prevent progression Remdesivir required secondary hemophagocytic lymphohistiocytosis shown syndrome the disease the SARS-CoV-2 therapeutic effect therapeutic effects therapy Treatment treatment approach viral replication [DOI] 10.1016/j.intimp.2022.109075 [Article Type] Review article
A review of clinical efficacy data supporting emergency use authorization for COVID-19 therapeutics and lessons for future pandemicsArticle Published on 2022-10-012022-11-15 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 치료제, [키워드] Anti-inflammatory Antiviral approved authorization chloroquine/hydroxychloroquine Clinical data Clinical efficacy clinical evidence clinical study clinical trial coronavirus disease COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical demonstrated drug Efficacy Emergency Emergency use authorization EUA Evidence FDA food Guidance majority medication Pandemics public health emergency question Randomized controlled trial RCT Regulatory Resilience statistically significant submitted subsequent Support supported therapeutic withdrawn [DOI] 10.1111/cts.13384 PMC 바로가기
Recent clinical findings on the role of kinase inhibitors in COVID-19 managementCOVID-19 관리에서 키나제 억제제의 역할에 대한 최근 임상 결과Review Published on 2022-10-012022-09-11 Journal: Life sciences [Category] 변종, 신약개발, 임상, 치료제, [키워드] activator affected alleviate Anti-inflammatory anti-viral effects antiviral agent Antiviral agents BTK clinical evidence Clinical finding Clinical practice clinical trial Complication complications Consequences coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRS cytokine release storm drug Efficacy glycogen synthase GSK-3 highly pathogenic inhibitor inhibitors JAK/STAT janus Janus kinase kinase Kinase inhibitor kinase inhibitors kinases management MAPK Novel coronavirus novel coronavirus disease outbreak p38 MAPK pandemic paradigm shift performed pharmacological pharmacological intervention protein kinase recent Signaling STAT therapy Transcription trials Viral load [DOI] 10.1016/j.lfs.2022.120809 PMC 바로가기 [Article Type] Review
Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19Article Published on 2022-09-252022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 치료기술, [키워드] acute phase Affect Brain changes in clinical evidence clinical study cognitive Cognitive impairment Combination Complication complications of COVID-19 COVID COVID-19 COVID-19 patients Demyelination detect disorders Factor fatigue Future help impairment include Inflammation Injury Insomnia knowledge lesions Long COVID manifestation mechanism Mental mental sequelae MRI Neuroimaging neurological neurological consequences Numerous Patient physiological post-COVID syndrome psychiatric disorder Psychological Quality of life quantification Quantitative Research role SARS-CoV-2 syndrome virus [DOI] 10.3390/ijms231911291 PMC 바로가기
Anti-HIV-drug and phyto-flavonoid combination against SARS-CoV-2: a molecular docking-simulation base assessmentSARS-CoV-2에 대한 항 HIV 약물 및 식물성 플라보노이드 조합: 분자 도킹 시뮬레이션 기반 평가Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] acute respiratory syndrome Analysis anti-HIV drug anti-HIV drugs Anti-inflammatory antimalarial drug Antimalarial drugs Antiviral clinical evidence Combination combination therapy combined effect complex coronavirus darunavir docking docking score drug drug-likeness eight enzyme flavonoid genome replication H-bond Health Hypothesis in viral individual Ligand ligands M pro MM/PBSA molecular molecular docking Molecular docking study molecular docking-simulation Patient phyto-flavonoid prophylactic therapy protease Protease inhibitor quercetin respiratory RMSF SARS-CoV-2 selected selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 stability viral genome replication [DOI] 10.1080/07391102.2021.1885495 PMC 바로가기 [Article Type] Article
Thromboembolic prevention and anticoagulant therapy during the COVID-19 pandemic: updated clinical guidance from the anticoagulation forumCOVID-19 대유행 중 혈전색전증 예방 및 항응고 요법: 항응고 포럼에서 업데이트된 임상 지침Article Published on 2022-08-012022-09-12 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, 진단, [키워드] anticoagulant therapy anticoagulation approach Aspirin clinical evidence clinical trial condition Consensus COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination Direct Direct oral anticoagulant Direct-acting oral anticoagulant enoxaparin Evidence Forum Guidance hospitalized patients In-hospital Low-molecular-weight heparin North observational study Patient patients hospitalized patients with COVID-19 Pregnancy Prophylactic Prophylaxis provide provided rivaroxaban. stewardship Thrombophilia Thromboprophylaxis Thrombosis and thrombocytopenia syndrome thrombotic Venous Thromboembolism [DOI] 10.1007/s11239-022-02643-3 PMC 바로가기 [Article Type] Article
Decoding clinical biomarker space of COVID-19: Exploring matrix factorization-based feature selection methodsCOVID-19의 임상 바이오마커 공간 디코딩: 매트릭스 인수분해 기반 특징 선택 방법 탐색Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] MERS, 바이오마커, 진단, [키워드] ABG Algorithm approach arterial arterial blood arterial blood gas Biomarker blood gas blood test blood tests C-reactive protein C-reactive protein (CRP Characteristics classification clinical Clinical biomarker clinical evidence Clinical management complex disease complex diseases COVID-19 COVID-19 crisis COVID-19 patient Critical Critical care CRP determine Dimensionality reduction Diseases Feature selection forest former global pandemic identify matrix Matrix factorization. morbidity path Patient patients performed poor prognosis Predictive Quantitative Random forest reveal saturation Selection unmet need [DOI] 10.1016/j.compbiomed.2022.105426 PMC 바로가기 [Article Type] Article
Performance of the TaqMan COVID-19 Pooling Kit for detection of SARS-CoV-2 in asymptomatic and symptomatic populations무증상 및 유증상 집단에서 SARS-CoV-2 검출을 위한 TaqMan COVID-19 풀링 키트의 성능Article Published on 2022-06-102022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm analytical sensitivity applicability Asymptomatic Asymptomatic case Asymptomatic cases Asymptomatic COVID-19 Chain Reaction China clinical clinical evidence Cohort cohorts coronavirus coronavirus disease COVID-19 curated demonstrated detect effective Evidence expected FIVE Frame gold gold standard higher education independent t-test labor lack nare nucleocapsid Open reading frame ORF ORF1ab P-value p-values pandemic PCR testing performance performed polymerase chain polymerase chain reaction pool pooling Population positive sample Prevalence Qualitative reported resource reverse transcriptase RNA RT-PCR RT-qPCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus strain supported surveillance testing Swab symptomatic symptomatic and asymptomatic t-test TaqMan transcriptase Volume Wuhan [DOI] 10.1371/journal.pone.0269798 PMC 바로가기 [Article Type] Article
Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccinesClinical and Translational Report Published on 2022-06-092022-10-04 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] Abstract Affect Analysis Animal experiment antibody antibody cross-reactivity antibody response against association B.1.617.2 Booster vaccine breadth China circulating clinical evidence clinical observation Cohort Commission conducted confounders Context cost-efficient strategy COVID-19 vaccination COVID-19 vaccine Department development elicit Evidence finding foundation funding Health care worker healthcare worker Heterologous heterologous prime-boost heterologous vaccination heterologous vaccine homologous homologous or heterologous immune responses immunological analysis inactivated Influenza Innovation International Laboratory test mechanism Multivariable regression natural Neutralization antibody neutralization titer Neutralizing Neutralizing activity physician PNA Program protective immunity Pseudovirus neutralization assay recipient SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Science Serum Neutralization Shenzhen shown significantly lower subsequent suggested technology the United State the vaccine vaccination vaccination schedule Vaccine Vaccines variant variants veteran Virus neutralization Wuhan-Hu-1 [DOI] 10.1016/j.medj.2022.05.003 PMC 바로가기 [Article Type] Clinical and Translational Report