Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: A comparative analysis across two New York hospitals입원한 COVID-19 환자의 사망 위험을 결정하기 위해 환자 바이오마커 시계열을 사용: 두 뉴욕 병원에 대한 비교 분석Article Published on 2022-08-182022-09-11 Journal: PLoS ONE [Category] SARS, 바이오마커, 치료기술, [키워드] Accuracy Admission Analysis Bayesian Biomarker Biomarkers center changes in clinical measurement cohorts COVID-19 COVID-19 patient death determine died difficulty discharge discharged explain Factor focus generalisability Health Sciences high risk high risk patients highlight hospital hospitalisation hospitalised hospitals Maimonide Maimonides Markov median Model Mortality mortality risk New New York outcome Patient patient cohort patient cohorts patient mortality patients Predictive prognostic model Prognostic models question raising restrict risk risk of COVID-19 Science sensitivity single hospital state tested university utility variables [DOI] 10.1371/journal.pone.0272442 PMC 바로가기 [Article Type] Article
Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identifies Critical Biomarkers of COVID-19우한의 여러 단계에 있는 환자의 혈청 대사체학 특성 분석으로 COVID-19의 중요한 바이오마커 식별Article Published on 2022-05-022022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alpha-methylstyrene Biomarker Biomarkers caused characterization chavicol clinical disease clinical measurement clinical measurements comprehensive analysis coronavirus Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical death degranulation differentially expressed example feature identification immune responses information Intervention involved knowledge lead metabolism metabolite metabolites metabolomic metabolomic analysis metabolomics Pathogenesis pathway Patient patients performed phosphate physiological Platelet potential therapeutic agent potential therapeutic agents predicted propylparaben rehabilitation patient respiratory SARS-CoV-2 sera serum severe acute respiratory syndrome Coronavirus Spread Stage stages therapeutic agents therapeutic target therapeutic targets triethanolamine uninfected Wuhan [DOI] 10.3389/fcimb.2022.882661 PMC 바로가기 [Article Type] Article
Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19COVID-19의 무증상, 증상 및 회복기에 걸친 면역 반응 패턴Article Published on 2022-02-012022-09-11 Journal: Biochimica et biophysica acta. Proteins and proteo [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated addition Analysis Asymptomatic asymptomatic infection causative agent cholesterol cholesterol metabolism clinical measurement clinical measurements complex convalescent COVID-19 COVID-19 infection Diagnosis disease disorder disorders dysregulated dysregulation identify immune defect immune defects immune response Immunopathogenesis Intervention mass mass spectrometry metabolism Mild myeloid cell myeloid cells Neutrophils pattern progression proteomics provide serum severe COVID-19 patients symptomatic the disease Urine [DOI] 10.1016/j.bbapap.2021.140736 PMC 바로가기 [Article Type] Article
Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 TherapeuticsPharmacology Published on 2021-08-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] arrhythmia Arrhythmias Azithromycin cardiac Cardiomyocytes Clinical findings clinical measurement clinical trial clinically clinician Combination combined efficacy COVID-19 debate drug drug response Drug screening drugs effective effective drugs effort Emergency use authorization evaluate events Evidence FDA Frequency global efforts HCQ heart heart muscle Hospitalization hospitalized COVID-19 patients Hydroxychloroquine identify increase in induced pluripotent stem cells Microphysiological systems MPS muscle platform pluripotent stem cell polytherapy predict predicted prediction Premature QT interval QT prolongation reflected resource Safe SARS-CoV-2 SARS-CoV-2 pandemic significant increase System Therapeutics time-consuming tissue treat treated treatment for COVID-19 was measured while worsening [DOI] 10.3389/fphar.2021.684252 PMC 바로가기 [Article Type] Pharmacology