Computational pathology: A survey review and the way forward ☆Review Article Published on 2024-01-142024-09-05 Journal: Journal of Pathology Informatics [Category] update2024, [키워드] Clinical pathology Computer aided diagnosis (CAD) deep learning digital pathology survey Whole slide image (WSI) [DOI] 10.1016/j.jpi.2023.100357 PMC 바로가기 [Article Type] Review Article
Ethnicity, Comorbid Medical Conditions, and SARS-CoV-2 Test Cycle Thresholds in the Veteran PopulationArticle Published on 2022-10-012022-11-15 Journal: Journal of racial and ethnic health disparities [Category] COVID19(2023년), SARS, 진단, [키워드] access Access to health care addition Admission affected African American age Care center clinical Clinical course Clinical pathology collected COVID-19 COVID-19 infection cycle difference disease severity Ethnic groups Ethnicity Factors Gender Health ICU care increases in information Intensive Medical conditions Molecular pathology outcome Patient Philadelphia polymerase chain Population Population demographics positive public health Quality Quality assurance Quality control required Research retrospective RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR test significantly statistically significant Test tested transcriptase veteran Viral load viral loads was performed [DOI] 10.1007/s40615-021-01114-4 PMC 바로가기
rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbitsrVSV-ΔG-SARS-CoV-2-S 백신: NZW 토끼에서 반복되는 근육내(IM) 독성, 국소 내성, 면역원성 및 생체 분포 연구Article Published on 2022-08-012022-09-11 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, 치료기술, [키워드] Administered animals antibody antibody levels Antibody titers Antigen assigned binding biodistribution biodistribution study body temperature body weight breath C-reactive protein change Clinical pathology Clinical signs clinical trial clinical trials correlated COVID-19 detection elicited evaluate Express followed by Gross High-dose high-dose group histopathological iliac lymph node immunogenicity inflammatory reaction injection intervals intramuscular intramuscularly Local local reactions Lymph node mesenteric lymph nodes Necrosis Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers New Nonclinical ophthalmology pathology Phase 2 platform Reactions repeated RNA Safe Safety SARS-CoV-2 SARS-CoV-2-S significant increase spleen stomatitis supported systemic the vaccine Tolerance Toxicity two group two groups Urinalysis vaccination Vaccine vaccine doses Vector-based vaccine vesicular stomatitis vesicular stomatitis virus Viremia VSV was performed [DOI] 10.1007/s00204-022-03302-5 PMC 바로가기 [Article Type] Article
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™SARS-COV-2 항바이러스 치료제 Paxlovid™의 적시 개발을 지원하는 Nirmatrelvir의 포괄적인 비임상 안전성 평가Article Published on 2022-08-012022-09-11 Journal: International journal of toxicology [Category] 치료제, [키워드] 3CL administration Antiviral Arrhythmias assessment blood pressure cardiovascular caused clinical development Clinical pathology coagulation time Comprehensive conducted COVID-19 COVID-19 patient COVID-19 patients death decrease decreases development dose Drug safety Effect Efficacy Endpoint enhancer enzyme functional heart rate high risk highest dose Hospitalization Increases increases in induce Infection locomotor male MPro nervous system Nirmatrelvir not affect pathology Paxlovid pharmacokinetic Potential produced profile protease RATs Replication respiratory rate Ritonavir Safety safety pharmacology SARS-CoV-2 SARS-CoV-2 virus Support Supporting target tested the SARS-CoV-2 virus toxicities Toxicity toxicology transaminase transaminases Treatment treatment of COVID-19 were assessed [DOI] 10.1177/10915818221095489 PMC 바로가기 [Article Type] Article
Coronavirus disease 2019 and the placenta: A literature review코로나바이러스 질병 2019 및 태반: 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus [DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review
Alterations in the molecular composition of COVID-19 patient urine, detected using Raman spectroscopic/computational analysis라만 분광/전산 분석을 사용하여 감지한 COVID-19 환자 소변의 분자 구성 변화Article Published on 2022-07-182022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Abnormalities Accuracy affected alteration Analysis analyzed Bladder cancer Care Chain Reaction Chromatography Clinical pathology collected complex component components computational analysis Contact contact with contributing to correlation correlations COVID-19 COVID-19 disease COVID-19 patient creatinine defined detect determine disease disease severity EGFR elevated fingerprint gas chromatography Gas Chromatography-Mass Spectrometry GC-MS glomerular filtration rate healthy healthy individual healthy individuals Hospitalized HPLC identify in urine include Infection Inflammatory liquid Liquid chromatography Long mass spectrometry metabolomic analysis Mild moderate molecular Negative predictive value pathology Patient patients performance Peritoneal dialysis positive Positive predictive value Predictive value Raman spectroscopy random ranged reaction representing respiratory RT-PCR SARS-CoV-2 virus sensitivity serum creatinine severity specificity specimen specimens Spectrometry Symptom symptomatic tested Urinalysis Urine urine specimens Viral Volunteer with COVID-19 [DOI] 10.1371/journal.pone.0270914 PMC 바로가기 [Article Type] Article
Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques붉은털 원숭이의 SARS-CoV-2에 대한 에어로졸화된 아데노바이러스 벡터 백신의 안전성, 점막 및 전신 면역 효능Coronaviruses Published on 2022-01-292022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] Ad5-nCoV Adenovirus Adenovirus-vectored vaccine aerosol Clinical pathology COVID-19 effective elicited examined immune responses Immunity immunogenicity immunoglobulin A indicated Infection inhalation initial mucosal mucosal immune mucosal immunity nCoV NHP Non-invasive organ organs pathology provide Replication respiratory Respiratory system responses against rhesus macaque rhesus macaques Safe Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine Spike protein subsequent Toxicity transmission of SARS-CoV-2 Vaccination strategy variants vectored vaccine [DOI] 10.1080/22221751.2022.2030199 PMC 바로가기 [Article Type] Coronaviruses
Viral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infectionComparative Study Published on 2021-12-012023-06-13 Journal: Emerging Microbes & Infections [Category] B형 간염, Fulltext, [키워드] Chronic Hepatitis B Clinical pathology decision support techniques machine learning natural history Quasispecies [DOI] 10.1080/22221751.2021.1919033 PMC 바로가기 [Article Type] Comparative Study
Analytical Performance of COVID-19 Detection Methods (RT-PCR): Scientific and Societal Concerns †Review Published on 2021-07-062022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] assays clinical information Clinical pathology concern COVID-19 COVID-19 disease Critical current demonstrated detection Diagnosis diagnostic procedures diagnostic test diffusion Epidemic epidemiological Evolution False negative False positive false-negative False-positive healthcare worker helping identify individual limit limitations management Outbreaks pandemic performance Perspective Prevent radiological reported required responsible RT-PCR SARS-CoV-2 screening procedure screening test sensitivity significantly Spread Swab the epidemic the SARS-CoV-2 time dependency viral infection virus [DOI] 10.3390/life11070660 PMC 바로가기 [Article Type] Review
Criticality of In-House Preparation of Viral Transport Medium in Times of Shortage During COVID-19 PandemicCOVID-19 팬데믹 기간 동안 바이러스 수송 매체의 자체 준비의 중요성Article Published on 2021-03-152022-09-12 Journal: Laboratory medicine [Category] SARS, 진단, [키워드] Balanced bovine Clinical pathology Community conducted COVID-19 COVID-19 pandemic diagnostic Efficacy emergency preparedness FBS feasible fetal HBSS heat-inactivated Laboratory laboratory workflow manuscript molecular Molecular pathology preparation provide Quality assurance Quality control salt SARS-CoV-2 serum solution specimen stability sterility supply shortage time viral transport media viral transport media preparation. Viral transport medium VTM were assessed [DOI] 10.1093/labmed/lmaa099 PMC 바로가기 [Article Type] Article