When to Stop Antibiotics in the Critically Ill?Review Published on 2024-03-182024-09-05 Journal: Antibiotics [Category] update2024, [키워드] Antibiotics antimicrobial resistance Biomarkers clinical response Duration of therapy fixed duration [DOI] 10.3390/antibiotics13030272 PMC 바로가기 [Article Type] Review
Assessment of Safety and Efficacy of Tofacitinib, Stratified by Age, in Patients from the Ulcerative Colitis Clinical ProgramArticle Published on 2023-01-052023-05-31 Journal: Inflammatory bowel diseases [Category] 두창, 수두, 홍역, [키워드] age clinical response Safety Tofacitinib ulcerative colitis [DOI] 10.1093/ibd/izac084 PMC 바로가기
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기
Dose optimisation and scarce resource allocation: two sides of the same coinArticle Published on 2022-10-122022-11-16 Journal: BMJ Open [Category] 신약개발, [키워드] clinical clinical pharmacology clinical response clinical trial clinical trials COVID-19 COVID-19 pandemic dose Future Healthcare system help majority medical ethics pandemic Public public health rationing resource [DOI] 10.1136/bmjopen-2022-063436 PMC 바로가기
Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor PaxlovidArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CLpro acute respiratory syndrome Analysis analyzed Antiviral antiviral drug Antiviral treatment antivirals baseline binding circulating cleavage clinical response conservation conserved Contact Coronaviral Coronaviridae family coronavirus COVID-19 COVID-19 pandemic Critical database determine drug target effort Emergency use authorization enzyme escape mutation EUA Evolution expected Genetic genomic GISAID globe health emergency implication inhibitor inhibitors initiative introduced isolate isolates M pro motifs MPro Mutation Nirmatrelvir pandemic progresse Paxlovid protease purifying selection raise reference sequence Region remained residue retrieved robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 viral selective sequence Sequencing starting point Surveillance the SARS-CoV-2 the spike protein Treatment unique variants variants of SARS-CoV-2 virus widespread Wuhan-Hu-1 [DOI] 10.1128/mbio.00869-22 PMC 바로가기
High Monocyte Count Associated with Human Cytomegalovirus Replication In Vivo and Glucocorticoid Therapy May Be a Hallmark of DiseaseArticle Published on 2022-08-242022-11-16 Journal: International Journal of Molecular Sciences [Category] 치료기술, [키워드] caused CD14 Characteristics clinical model/translational medicine clinical response Clinical symptoms CMV comparable correlated corticosteroid therapy count COVID-19 cytomegalovirus cytomegalovirus (CMV) kinetics decrease defined definitions of cytomegalovirus disease described Dexamethasone disease dose glucocorticoid growth hallmark healthy subjects homogeneous homogeneous sample of subjects logarithmic phase of infection Human Increased Infection Infectious disease innate immune innate immune response investigated leukopenia lymphopenia macrophages molecular monocyte monocytes characteristics and analysis monocytosis mononucleosis neutropenia observation onset of fever pathogen detection Patient prodrome Replication Sample Significant steroid subject syndrome tested the median viral infection Viral load viral replication Viremia virome virus virus replication [DOI] 10.3390/ijms23179595 PMC 바로가기
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species노출 방식은 여러 비인간 영장류 종에서 바이러스 역학에 영향을 미치지만 COVID-19의 호흡기 결과에는 영향을 미치지 않습니다Article Published on 2022-07-052022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] aerosol exposure African African green monkeys AGM AGMs animal model animal models ARDS change Characteristics Chlorocebus clinical clinical response Clinical sign Clinical signs Cohort conserved COVID-19 COVID-19 disease cytokine response demonstrated demonstration develop expand exposure functional greater include infected with SARS-CoV-2 Infection influence intranasal lack lung damage magnitude Medical countermeasures mucosal mucosal exposure myeloid cell Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic status Pathogenesis Pathologies pleuritis Pulmonary pathology reached regenerative Research rhesus rhesus macaques route SARS-COV-2 infection severe disease small particle aerosol species tested therapeutic utility variants variants of concern viral kinetics Viral load [DOI] 10.1371/journal.ppat.1010618 PMC 바로가기 [Article Type] Article
The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational studySARS-CoV-2 관련 폐렴으로 입원한 환자에서 비만과 이상지질혈증이 렘데시비르 효과에 미치는 영향: 관찰 연구Observational Study Published on 2022-07-012022-09-11 Journal: Nutrition, metabolism, and cardiovascular diseases [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI 95%CI average BMI Catania clinical Clinical improvement clinical response conducted COVID-19 dyslipidemia Effectiveness evaluate evaluated GS-5734 Hospitalization hospitalized COVID-19 patients hospitalized patient individuals inhibitor intensive care internal internal medicine Italy LDL-C Medicine metabolic condition metabolic parameter Mortality mortality rate obesity observational study Ordinal Scale Patient Pneumology Pneumonia predict preliminary findings Prevalence Remdesivir RNA polymerase SARS-CoV-2 scale significantly significantly lower subject the mean therapeutic treated unit Viral RNA was used [DOI] 10.1016/j.numecd.2022.04.005 PMC 바로가기 [Article Type] Observational Study
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting Reviews Published on 2022-06-212022-10-05 Journal: Nature reviews. Rheumatology [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] approaches autoinflammatory disease cells characterized clinical feature clinical response clinician conditions diagnostic Diseases disorder dysregulation epidemiological Fever Genotype IL-1 include innate immune innate immune system mechanism mouse model mutant over Pathogenesis pathogenic mutations pathophysiological Patient patients Perspective Phenotypes regulated rheumatologist specific diseases subsequent syndrome systemic inflammation targeted therapy therapeutic targeting therapy [DOI] 10.1038/s41584-022-00797-1 [Article Type] Reviews
A phase I trial of cyclosporine for hospitalized patients with COVID-19Clinical Trial Published on 2022-06-082022-10-04 Journal: JCI Insight [Category] Coronavirus, COVID19(2023년), SARS, 임상, [키워드] administration adverse events antiviral property application Care center characterized chemokine chemokines clinical response conducted Course COVID-19 CsA CXCL10 cyclosporine A cytokine production Cytokine storm Cytokines discharged disease dose drug evaluated exacerbated feasible gene expression signature gene-expression Health health emergency healthcare Hospitalized hospitalized patient hyperinflammation ill patient immune dysregulation inhibitor intensive care modulate New oxygen participant Patient patients with COVID-19 peripheral blood cell Phase I reduction in reductions in Registered required resource Safe serum cytokine transaminitis transcriptional profile treated Treatment Trial Type I IFN Vaccine with COVID-19 [DOI] 10.1172/jci.insight.155682 PMC 바로가기 [Article Type] Clinical Trial