A Pilot Study to Detect Viable Salmonella spp. in Diarrheal Stool Using Viability Real-Time PCR as a Culture-Independent Diagnostic Tool in a Clinical Setting임상 환경에서 배양 독립 진단 도구로서 생존 가능성 실시간 PCR을 사용하여 설사 대변에서 생존 가능한 살모넬라 spp.를 검출하기 위한 파일럿 연구Article Published on 2023-06-102024-08-22 Journal: International Journal of Molecular Sciences [Category] 살모넬라증, [키워드] clinical setting diarrheal stools False positives qPCR Salmonella spp stool enrichment viability assessment viability qPCR.
Rapid detection of SARS-CoV-2 variants of concern by single nucleotide polymorphism genotyping using TaqMan assaysArticle Published on 2022-12-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Accuracy acute respiratory syndrome approach B.1.1.7 B.1.526 clinical setting Concordance coronavirus coronavirus disease 19 Coronavirus disease 19 (COVID-19) E484K evaluated genotyping mutations N501Y nasopharyngeal Negative predictive value New York City nonsynonymous patient population polymorphism positive positive sample predicted ranged Rapid Real-time reverse-transcription PCR residual RT-qPCR SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variant sensitivity Sequencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly lower single nucleotide specificity Spike protein submitted subset TaqMan TaqMan assay Thermofisher variant variants variants of concern were used WGS whole genome [DOI] 10.1016/j.diagmicrobio.2022.115789 PMC 바로가기
Increased Detection of Carbapenemase-Producing Enterobacterales Bacteria in Latin America and the Caribbean during the COVID-19 PandemicArticle Published on 2022-11-012022-11-16 Journal: Emerging Infectious Diseases [Category] 치료기술, [키워드] acute respiratory syndrome antibiotic use antimicrobial resistance Bacteria Bacterial infection Carbapenemase-producing Enterobacterales change characterized clinical setting coronavirus coronavirus disease Corso A country COVID-19 COVID-19 cases COVID-19 pandemic detection enteric infections et al. Increased detection of carbapenemase-producing Enterobacterales bacteria in Latin America and the Caribbean during the COVID-19 pandemic. Emerg Infect Dis. 2022 Nov [date cited]. https://doi.o food safety healthcare help increase Increased Infection prevention isolates Latin Latin America limitation Pasterán F Pillonetto M Prevalence Prevent reported Research respiratory infections resulting SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Shal J Sosa A Suggested citation for this article: Romero Thomas G Surveillance the Caribbean Thoma Transmission viruses zoonoses [DOI] 10.3201/eid2811.220415 PMC 바로가기
Evaluating diagnostic accuracies of Panbio™ test and RT-PCR for the detection of SARS-CoV-2 in Addis Ababa, Ethiopia using Bayesian Latent-Class Models (BLCM)Article Published on 2022-10-192022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Accuracy Ag-RDTs Bayesian clinical setting cough COVID-19 COVID-19 pandemic CrI criteria cross-sectional diagnostic diagnostic sensitivity diagnostics enrolled evaluate Evaluating exhibited expected females health center hospitals individual majority Model MOST pandemic Patient performed positive positive RT-PCR Rapid rapid antigen test Rapid diagnostic test reference standard reported RT-PCR SARS-CoV-2 sensitivity specificity Study participants symptomatic and asymptomatic the WHO Transmission was done without symptoms [DOI] 10.1371/journal.pone.0268160 PMC 바로가기
RT-LAMP assay combining multi-fluorescent probes for SARS-CoV-2 RNA detection and variant differentiationSARS-CoV-2 RNA 검출 및 변이체 분화를 위한 다중 형광 프로브를 결합한 RT-LAMP 분석Article Published on 2022-10-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] addition applied can be used clinical setting clinical settings detect Fluorescent probes Genes isothermal amplification limit of detection Loop-mediated isothermal amplification molecular mutant Mutation N gene observation ORF1 ORF1ab P681H P681R positive result primer set probe quantification regions reverse transcription Reverse transcription loop-mediated isothermal amplification (RT-LAMP) RT-LAMP S gene SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection SARS-CoV-2 viral RNA sensitivity simple specificity Spread Transcription type strain variant Variant differentiation. viral RNA detection virus wild type wild type strain wild-type [DOI] 10.1016/j.talanta.2022.123644 PMC 바로가기 [Article Type] Article
Clinician Perspectives on Monoclonal Antibody Treatment for High-Risk Outpatients with COVID-19: Implications for Implementation and Equitable AccessArticle Published on 2022-10-012022-11-15 Journal: Journal of General Internal Medicine [Category] 진단, [키워드] access acute care Care clinical setting clinical settings clinician Complete COVID-19 death diffusion diffusion of innovations dissemination dissemination and implementation eligibility criteria eligible Eligible patients Evidence facilitate Factor feasibility feasible health systems Hospitalization identify indicated knowledge mAb mAbs management monoclonal antibody MOST Outpatient Patient patients with COVID-19 primary care public health reduce referral. reported respondent survey therapy Treatment with COVID-19 [DOI] 10.1007/s11606-022-07702-2 PMC 바로가기
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기
Vitamin D modulates systemic inflammation in patients with severe COVID-19Research article Published on 2022-10-012022-10-05 Journal: Life sciences [Category] 바이오마커, 임상, 치료기술, [키워드] AKT Anti-inflammatory effects attenuate Blood blood sample C-reactive protein clinical setting condition COVID-19 COVID-19 infection D-dimer ELISA evaluate expression Hyperinflammatory ICU IL-17 IL-1β IL-6 immune response immunomodulatory in vitro Inflammatory response intensive care investigated JNK marker material modulate Nasopharyngeal swab pathway Patient patients PBMC Proinflammatory cytokine reveal Serum level severe COVID-19 severity signaling pathway Significance STAT3 stimulated systemic inflammation treated treated patient Treatment untreated patient Vitamin D was used western blotting with COVID-19 [DOI] 10.1016/j.lfs.2022.120909 [Article Type] Research article
Decontamination of Geobacillus Stearothermophilus using the Arca Aerosolized Hydrogen Peroxide decontamination systemArticle Published on 2022-09-202022-11-16 Journal: PLoS ONE [Category] SARS, 임상, 치료기술, [키워드] Bacterial biologic caused clinical setting Concentration conducted Control decontamination effective Efficacy eight evaluate evaluated Greater than growth H2O2 hydrogen Indicator inoculated material Mesa negative control negative controls pandemic peroxide Personal protective equipment positive positive control PPM produced Respirator reuse SARS-CoV-2 sealed Seven System Trial trials [DOI] 10.1371/journal.pone.0273937 PMC 바로가기
Stem cell-based therapy for human diseases Reviews Published on 2022-08-062022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 임상, 치료제, [키워드] acute respiratory distress adipose Bone marrow Brain burns candidate cardiovascular conditions Cell cell type cellular phenotype clinical setting clinical trial contribute defined disease Diseases disorder disorders downstream human disease human diseases Hypothesis in vitro ISCT lineages mechanism MSC MSCs Neurological disorders Patient pluripotent stem cell progenitor cell provide pulmonary disease recent regenerative reproductive Research Society Spinal cord injury STEM stem cell Support syndrome targeted therapy therapy tissue translational treated Treatment UC-MSC umbilical [DOI] 10.1038/s41392-022-01134-4 [Article Type] Reviews