Evaluation of indirect sequence-specific magneto-extraction-aided LAMP for fluorescence and electrochemical SARS-CoV-2 nucleic acid detectionArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, 치료제, [키워드] amplification approach circumvent clinically Disadvantages Electrochemical LAMP Host in silico inhibitor investigated isothermal isothermal amplification Magnetic sequence-specific target enrichment molecular NAAT nucleic acid Nucleic acid detection PCR polymerase probe qRT-PCR Quantitative Quantitative real-time LAMP real-time reverse transcriptase restrict SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 variant sensitivity sequence serum turn [DOI] 10.1016/j.talanta.2022.123809 PMC 바로가기
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain원숭이와 생쥐의 비교 miRNA 전사체는 MYOC가 뇌로의 크립토코커스 네오포르만스 침입에 대한 억제제임을 보여줍니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] 유전자 메커니즘, [키워드] AIDS Brain brain dissemination brains C. neoforman C. neoformans caused Central nervous system centric clinical samples clinically CNS Comparative Cryptococcal meningoencephalitis cryptococcosis Cryptococcus neoforman Cryptococcus neoformans cytoskeleton dissemination enhancer facilitate fungal Fungal infection help HIV/AIDS HIV/AIDS patient HIV/AIDS patients host-pathogen interactions hosts human pathogen Immune cell immune cells individuals Infection inhibitor inhibitors Invasion macaque Macrophage mechanism meningoencephalitis mice miRNA miRNA transcriptome. MYOC myocilin Pathogenic microorganisms pathway Patient patients with COVID-19 performed Prevalence regulated response reveal Transcriptome transcriptomics Trojan horse [DOI] 10.1080/22221751.2022.2081619 PMC 바로가기 [Article Type] Article
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기
Anxiety and depression in the post-pandemic era: concerns about viral mutation and re-outbreakArticle Published on 2022-11-032022-11-16 Journal: BMC Psychiatry [Category] SARS, 변종, [키워드] Anxiety changes in China city clinically Complete conducted convenience sampling coronavirus COVID-19 critically ill patients Depression difference East effective Factor female GAD-7 groups Health healthy help illness IMPROVE infected patient infected patients likelihood logistic regression model males mental health no significant difference outbreak pandemic Patient Perception PHQ-9 Population Psychological psychological reaction public health system question questionnaire Questionnaires reduced reported required risk factor severity significant level Support the patient variant viral mutation [DOI] 10.1186/s12888-022-04307-1 PMC 바로가기
Concurrent coronavirus disease 2019 and primary syphilis in a young man: A rare case reportArticle Published on 2022-11-012022-11-15 Journal: Journal of infection and chemotherapy : official j [Category] 진단, [키워드] Admission amoxicillin antibody Case report cause clinically Computed tomography concurrent coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic diagnosed diagnosis of COVID-19 disease early diagnosis Favipiravir genital help incidence Infection lesion Lymph node pandemic patients with COVID-19 plasma Pneumonia positive Prevalence Quantitative quantitative test Rapid Rapid plasma reagin quantitative test reagin reduction in reported serum severe hypoxemia sexual intercourse Symptom syphilis Treatment Treponema pallidum Treponema pallidum antibody. [DOI] 10.1016/j.jiac.2022.07.008 PMC 바로가기
Distance-based detection of out-of-distribution silent failures for Covid-19 lung lesion segmentationResearch article Published on 2022-11-012022-10-05 Journal: Medical image analysis [Category] 치료기술, [키워드] 68T30 68T37 68T45 approach Automatic chest computer tomography Chest CT clinically consolidation deep learning detect distribution Ground glass opacity lung magnetic resonance imaging Prostate quantification radiologist resource silent [DOI] 10.1016/j.media.2022.102596 [Article Type] Research article
Assessment of dental health care personnel protocol deviations and self-contamination during personal protective equipment donning and doffingArticle Published on 2022-11-012022-11-15 Journal: Journal of the American Dental Association (1939) [Category] SARS, 치료기술, [키워드] abdomen acute respiratory syndrome Analysis applied assessment Care cause clinically coronavirus COVID-19 dental Dental health Dental infection control description deviation doffing donning enrolled eye protective devices Face mask Factor Fluorescence fluorescent Frequency gloves, protective Health health, occupational. highest hygiene increased risk Infection involved marker Masks observation participant pathogen transmission Pathogens performed Personal protective equipment PPE PPE donning Protective protocol recorded reduce significantly virus were assessed [DOI] 10.1016/j.adaj.2022.08.004 PMC 바로가기
Incidence and outcome of SARS-CoV-2 infection in a pediatric kidney transplant recipient cohort from a single center in Northern ItalyArticle Published on 2022-11-012022-11-16 Journal: Pediatric transplantation [Category] COVID19(2023년), SARS, 치료기술, [키워드] adolescents children clinically Cohort concern contrary COVID-19 criteria detect duration of symptom Effect eight enrolled epidemiological high risk hospital Immunocompromised patients incidence IQR Italy kidney kidney transplant mortality rate Nasopharyngeal swab observation period outcome Patient pediatric pediatric kidney transplant pediatric transplantation performed Population positive patients positive RT-PCR recipient recipients renal required risk RT-PCR RT-PCR test RT-PCR testing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 single center solid organ transplant solid organ transplantation SOT specific treatment Swab symptomatic Test tested the healthy therapy [DOI] 10.1111/petr.14335 PMC 바로가기