The effect of a clock’s presence on trauma resuscitation times in a Dutch level-1 trauma center: a pre–post cohort analysisOriginal Article Published on 2023-10-042024-09-05 Journal: European Journal of Trauma and Emergency Surgery [Category] update2024, [키워드] CLOCK Resuscitation time trauma Trauma team [DOI] 10.1007/s00068-023-02371-0 PMC 바로가기 [Article Type] Original Article
Biomarkers of agingCover Article Published on 2023-04-112024-09-05 Journal: Science China Life Sciences [Category] update2024, [키워드] aging Biomarker CLOCK senescence [DOI] 10.1007/s11427-023-2305-0 PMC 바로가기 [Article Type] Cover Article
A cautionary note on altered pace of aging in the COVID-19 era코로나19 시대 고령화 속도 변화에 대한 주의사항Article Published on 2022-07-012022-09-11 Journal: Forensic science international. Genetics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accumulated acute respiratory syndrome Affect age aging all-cause mortality Alter Blood chronological age Clinical research CLOCK confounder Corona virus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 pandemic DNA methylation DNA methylation markers Effect Epigenetic Forensic Forensic age estimation heterogeneous nature Immune cell immune cells immune response individual individuals Interpretation joint life style management marker Modification modify molecular mortality risk pace pandemic pathogen Pathogens Pathologies pathology performed persistence Perturbation perturbations reliability Research respiratory risk SARS-CoV-2 SARS-CoV-2 pandemic scar Severe acute respiratory syndrome SjTREC syndrome T-cell receptor telomere Telomere Length the SARS-CoV-2 These data vaccination virus [DOI] 10.1016/j.fsigen.2022.102724 PMC 바로가기 [Article Type] Article
Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol receptor transcription in the lungs and colon of male rats17β-estradiol이 수컷 쥐의 폐와 결장에서 ACE2, ADAM17, TMPRSS2 및 estradiol 수용체 전사의 일일 패턴에 미치는 영향Article Published on 2022-06-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol ACE2 ACE2 mRNA ADAM17 Administered administration amplitude analysed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Bmal1 Cell CLOCK Colon component components dosage Effect enzyme ESR1 ESR2 expression Features female GPER1 greater implicated lung Lungs male men molecules mRNA expression pathway pharmacological progression receptor Regulation Renin renin-angiotensin system rhythm sampling SARS-CoV-2 SARS-CoV-2 entry shown survival rate the SARS-CoV-2 the timing therapy tissue TMPRSS2 Transcription Treatment was performed women [DOI] 10.1371/journal.pone.0270609 PMC 바로가기 [Article Type] Article
duper is a null mutation of Cryptochrome 1 in Syrian hamstersduper는 시리아 햄스터의 Cryptochrome 1의 null 돌연변이입니다.Article Published on 2022-05-032022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] allele Biomedical research Bioscience caused circadian clock circadian rhythm CLOCK conserved Cry1 Cry1-null Cryptochrome dataset de novo facilitate fast homozygosity mappings Genetic genome assembly genomic hamster hamsters homozygosity mapping limb Limited Mesocricetus Mutation Oxford Nanopore Technologies Phase shift Protein recessive mutation resource sequencing data short circadian period length. Syrian hamster genome [DOI] 10.1073/pnas.2123560119 PMC 바로가기 [Article Type] Article
Evidence-based dosing of convalescent plasma for COVID-19 in future trials향후 시험에서 COVID-19에 대한 회복기 혈장의 증거 기반 투여Review Published on 2022-05-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody Antibody test CLOCK convalescent plasma ConvP coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Donor Donor selection donors dose doses Dosing Efficacy Evidence Guidance identifying Immunity International international units monoclonal monoclonal antibodies monoclonal antibody mRNA vaccination neutralize neutralizing antibody neutralizing antibody titres neutralizing monoclonal antibodies omicron Omicron variant pandemic Patient care performed Pharmacodynamics pharmacokinetics plasma unit premise respiratory SARS-CoV-2 selection process Support the patient therapy titre Treatment Trial turn variant variants Virus neutralization virus-neutralizing virus-neutralizing antibody Volume [DOI] 10.1016/j.cmi.2022.01.026 PMC 바로가기 [Article Type] Review
The Emergence of SARS-CoV-2 Variants of Concern Is Driven by Acceleration of the Substitution Rate우려의 SARS-CoV-2 변형의 출현은 대체율의 가속화에 의해 주도됩니다Discoveries Published on 2022-02-172022-09-10 Journal: Molecular Biology and Evolution [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, [키워드] acceleration Analysis analyzed antigenicity Bayesian model selection changes in CLOCK concern Course current driven by emergence estimate Evolution faster Genome Genome sequence data GISAID database increase in Lineage lineages molecular molecular clock molecular evolution Mutation mutations Phylogenetic Rate SARS-CoV-2 SARS-CoV-2 molecular evolution SARS-CoV-2 pandemic statistical Substitution These data Transmissibility variants variants of concern virus VoC VOCs [DOI] 10.1093/molbev/msac013 PMC 바로가기 [Article Type] Discoveries
Is There a Link between Circadian Clock Protein PERIOD 3 (PER3) (rs57875989) Variant and the Severity of COVID-19 Infection?일주기 시계 단백질 PER3(PER3)(rs57875989) 변이체와 COVID-19 감염의 심각도 사이에 연관성이 있습니까?Article Published on 2021-12-012022-09-11 Journal: Current medical science [Category] SARS, 변종, [키워드] circadian rhythm CLOCK Comorbidity Control Corona corona virus disease 2019 correlation Course COVID-19 COVID-19 patients diagnosed with COVID-19 distribution dysregulation Effect event examined Follow-up Genotype guide healthy control healthy controls hospital Host immune system initial gene intensive care Mortality no significant difference Patient patient groups PER3 polymorphism Prognosis recruited significant difference significantly higher significantly more statistical significance subgroup the healthy the patient Virus Disease Volunteer [DOI] 10.1007/s11596-021-2442-y PMC 바로가기 [Article Type] Article
Phylogenetic reconstruction of the initial stages of the spread of the SARS-CoV-2 virus in the Eurasian and American continents by analyzing genomic data게놈 데이터 분석을 통한 유라시아 및 미주 대륙의 SARS-CoV-2 바이러스 확산 초기 단계의 계통발생적 재구성Article Published on 2021-11-012022-09-11 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, [키워드] America analyzed Asia Betacoronavirus characterized China CLOCK coding region comparable Complete coronavirus country COVID-19 COVID-19 pandemic enterovirus Europe Evolution Evolutionary rate First wave Genetic polymorphism Genome genomic data Genomics genus genus Betacoronavirus human population human RNA Infection initial Middle East molecular molecular clock nucleotide nucleotide substitution pathway Pathways Phylogenetic RaTG13 Result rubella rubella virus Sample SARS-CoV-2 SARS-CoV-2 genome separated Spread Stage the SARS-CoV-2 genome the SARS-CoV-2 virus virus virus spread [DOI] 10.1016/j.virusres.2021.198551 PMC 바로가기 [Article Type] Article
Quantifying bacterial evolution in the wild: A birthday problem for Campylobacter lineages야생에서 박테리아 진화를 정량화 : 캄 필로 박터 계통의 생일 문제Research Article Published on 2021-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy addition alteration Analysis approach approaches Bacteria Bacterial bacterium birthday problem Campylobacter Campylobacter jejuni clinical isolates CLOCK clock rate dataset DNA replication ecological effective estimates estimation event Evolution focus gastroenteritis gene transfer Genome genomic growth help horizontal gene Horizontal gene transfer Host humans identifying infect information introduced isolates lead Lineage lineages maintenance molecular molecular evolution Non-synonymous not applicable nucleotide nucleotide change nucleotide changes nucleotide sequence organism outbreak pathogen pathogenic bacteria pathogenic strains Pathogens Population Probability provide reducing reflect Region reproduction robust sampling selected Spread strain Strains synonymous toolkit transfer Transmission turnover Variation [DOI] 10.1371/journal.pgen.1009829 PMC 바로가기 [Article Type] Research Article