The Senescent Heart—“Age Doth Wither Its Infinite Variety”Review Published on 2024-03-222024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] aging Cardiac fibroblasts cardiac fibrosis cardiac myocytes collagen DDR2 senescence vascular cells [DOI] 10.3390/ijms25073581 PMC 바로가기 [Article Type] Review
High-Resolution Phase-Contrast Tomography on Human Collagenous Tissues: A Comprehensive ReviewReview Published on 2023-11-272024-09-05 Journal: Tomography [Category] update2024, [키워드] collagen human body phase-contrast tomography soft tissues Synchrotron radiation [DOI] 10.3390/tomography9060166 PMC 바로가기 [Article Type] Review
CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasiaarticle Published on 2023-10-242024-09-05 Journal: Inflammation and Regeneration [Category] update2024, [키워드] bronchopulmonary dysplasia collagen CXCL10 elastic fibers hyperoxia Lung matrix remodeling [DOI] 10.1186/s41232-023-00301-6 PMC 바로가기 [Article Type] article
Subtle vascular and astrocytic changes in the brain of coronavirus disease 2019 (COVID-19) patientsArticle Published on 2022-12-012022-11-15 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, [키워드] Activation acute respiratory syndrome analysed Analysis AQP4 aquaporin 4 Astrocyte astrocytes Blood Brain brain blood vessels calculated CD31 Central nervous system change changes changes in co-expression collagen control patient controls coronavirus coronavirus disease COVID-19 COVID-19 cases COVID-19 patients decrease described endothelial fluorescent Fractal dimension GFAp immunohistochemistry Infection inflammatory signalling light microscopy lymphocyte membrane membranes microglial morphological change morphology Patient patients perivascular Protein reduced reduction SARS-CoV-2 SARS-COV-2 infection significantly increased Vascular vascular basement membranes. vessel [DOI] 10.1111/ene.15545 PMC 바로가기
Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor?Article Published on 2022-11-012023-07-10 Journal: BioFactors (Oxford, England) [Category] COVID19(2023년), [키워드] ADP collagen coronavirus human platelet-rich plasma Monocytes platelet-activating factor Platelets Spike protein thrombin Vaccines [DOI] 10.1002/biof.1877 PMC 바로가기
Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19Research article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory distress Affect Algorithm Analysis antiviral therapy Brain causes clinical study Col1a1 collagen Comorbidities Complication complications component Control coronavirus COVID-19 COVID-19 patients develop diagnostic drug drug repositioning FDA approved drug Genetic help immune system independent Infection Inflammation Inflammatory response Influenza involved kidneys Lungs machine learning methodology offer other organ pathway Pathways Patient performed principal Regulation response responsible Result reveal RSV SARS-CoV-2 SARS-COV-2 infection severity Side effect Side effects Small scale genetic signature susceptibility syndrome the disease the interferon Transcriptome transcriptomic transcriptomic analysis transcriptomic data virus replication [DOI] 10.1016/j.compbiomed.2022.106029 [Article Type] Research article
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome alveolar Antiviral cells chronic disease chronic inflammation clinical recovery collagen composed coronavirus coronavirus disease COVID-19 develop disease severity dysfunction dysregulated EIDD-2801 epithelial fibroblasts fibrosis histologic finding humans identify Immune cell individual Intervention lack lesion longitudinal lung abnormality lymphoid mice mouse-adapted SARS-CoV-2 murine model Nintedanib PASC Pathogenesis pathway Population proliferative provide pulmonary disease reduced regions SARS-CoV-2 SARS-COV-2 infection structures subpleural subset syndrome tissue samples transcriptional virus clearance [DOI] 10.1126/scitranslmed.abo5070 PMC 바로가기
Acquired von Willebrand Syndrome and Desmopressin Resistance During Venovenous Extracorporeal Membrane Oxygenation in Patients With COVID-19: A Prospective Observational StudyObservational Study Published on 2022-08-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] Acquired acute respiratory distress age analyses Analysis Antigen ARDS benefit binding bleeding collagen Comorbidities Comprehensive correlated COVID-19 COVID-19 patient COVID-19-associated ARDS decrease desmopressin Effectiveness elevated Extracorporeal extracorporeal membrane oxygenation ICU incidence male measurement not affect parameter parameters Patient performed polyacrylamide gel Prospective resistance screening test severity sodium syndrome thrombosis treated Treatment undetectable variable von Willebrand factor [DOI] 10.1097/CCM.0000000000005467 PMC 바로가기 [Article Type] Observational Study
Plasmodium vivax Protein PvTRAg23 Triggers Spleen Fibroblasts for Inflammatory Profile and Reduces Type I Collagen Secretion via NF-κBp65 Pathwayarticle Published on 2022-06-302024-09-01 Journal: Frontiers in immunology [Category] 말라리아, [키워드] collagen NF-κBp65 pathway Plasmodium vivax PvTRAg23 spleen fibroblasts [Article Type] article
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19Research article Published on 2022-06-172022-10-05 Journal: iScience [Category] 바이오마커, 임상, [키워드] Analysis Biological sciences Clinical finding Clinical outcome clinical outcomes collagen Concordance controls Coronavirus disease-19 COVID-19 COVID-19 disease severity COVID-19 patient cross talk disease global healthcare Hospitalized human metabolism immune modulation independent datasets Interaction Medicine metabolism metabolite metabolomic metabolomics molecular morbidity morbidity and mortality Mortality nucleotide outcome measure pandemic pathogenic performed Physiology predict predictive power Protein proteomic serum severe COVID-19 severe disease vascular homeostasis [DOI] 10.1016/j.isci.2022.104612 [Article Type] Research article