SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
Integrating in silico and in vivo approach for investigating the role of polyherbal oil in prevention and treatment of COVID-19 infectionArticle Published on 2022-11-012022-11-15 Journal: Chemico-biological interactions [Category] SARS, 변종, 치료제, [키워드] ACE2 Analysis angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory activity antiviral drug approach approved combating Compound contribute Control COVID-19 COVID-19 infection COVID-19 patients cytokine Efficacy ELIXIR entry of SARS-CoV-2 expression FDA GC-MS group groups hamster hamsters human host in silico in vivo in-silico Infection inhibiting inhibitory effect investigated Lung injury male membrane molecular docking molecular docking studies new SARS-CoV-2 PCR Polyherbal oil Prophylactic Protective real time receptor reduced respiratory diseases SARS-CoV-2 selected significantly Spike protein the SARS-CoV-2 Therapeutics these compound treat Treatment treatment groups Vaccine variants viral envelope Viral load [DOI] 10.1016/j.cbi.2022.110179 PMC 바로가기
Understanding and combating COVID-19 using the biology and chemistry of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Bioprocess and biosystems engineering [Category] SARS, 치료기술, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Asymptomatic binding caused combating contributed coronavirus coronavirus disease COVID-19 enzyme high affinity host receptor hydrophobic Infection Interaction lead to fatality Like molnupiravir Mutation Nanotechnology omicron pandemic pathogenic viruses PAXLOVID™ provide quercetin Remdesivir responsible SARS-CoV-2 spike glycoprotein suggested Transmissibility understanding Vaccine Vaccines viability virus [DOI] 10.1007/s00449-022-02788-8 PMC 바로가기
An outlook on potential protein targets of COVID-19 as a druggable siteArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] approved cause claimed clinical trial combating contagious COVID-19 COVID-19 disease Cryo-electron microscopy Delta Efficacy feature genomic help host cell host protein infecting inhibit mechanism of action MERS-CoV Mutation non-structural proteins omicron pandemic Protein Protein target proteolytic cleavage raised Repurposed drug required SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protein shown similarity spike Spike protein strain suggested the vaccine therapeutic drugs therapeutic interventions Vaccines variants of SARS-CoV-2 viral infection virus Wuhan X-ray diffraction [DOI] 10.1007/s11033-022-07724-3 PMC 바로가기
Temporal Events Detector for Pregnancy Care (TED-PC): A rule-based algorithm to infer gestational age and delivery date from electronic health records of pregnant women with and without COVID-19Article Published on 2022-10-312022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy age Algorithm Characteristics chronic obstructive clinical information Cohort combating common COVID COVID-19 COVID-19 pandemic Critical detect Detector develop diabete distress EHR Electronic health record event extreme gestation granularity Health identifying information material Model normalized obesity outcomes partnership performed Pregnancy pregnant women Prevalence pulmonary disease Record Respiratory failure resulting SARS-COV-2 infection SARS-CoV-2 viral infection Support syndrome Temporal the timing Validity viral infection with COVID-19 [DOI] 10.1371/journal.pone.0276923 PMC 바로가기
Diagnostic performance of corona virus disease 2019 chest computer tomography image recognition based on deep learning: Systematic review and meta-analysisArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy article articles assist AUROC authors characteristic Chest chest computer tomography China Cochrane Library combating country COVID-19 COVID-19 pandemic COVID-19 patient deep learning defined demographics Diagnosis diagnostic Final healthy highest inception inclusion criteria individual Infrastructure likelihood ratio Meta-analysis non-infected Odds ratio outcome Patient patients Pneumonia positive Predictive produced radiologist Research researcher resolved ROC Sample size screened searched secondary sensitivity Sensitivity and specificity specificity subgroup suspected patient Symptoms Virus Disease Web of Science [DOI] 10.1097/MD.0000000000031346 PMC 바로가기
Environmental Impacts on COVID-19: Mechanisms of Increased SusceptibilityArticle Published on 2022-10-212022-11-16 Journal: Annals of Global Health [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition age Air pollution antioxidant benefit boost caused changes in children clinical symptom combating coronavirus COVID COVID 19 COVID-19 COVID-19 susceptibility death described disease Diseases Environment Epidemiology exposure to free radical Health host immunity host susceptibility Impact Increased induce Inflammatory cytokine storm inhibit Initially International involved knowledge less mechanism morbidity and mortality outcomes oxidative stress pediatric Preliminary data reduce respiratory tract respiratory viral infections SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severity severity of COVID-19 shown susceptibility susceptible the disease Vaccine variant viral genome viral infections viral pathogenicity while [DOI] 10.5334/aogh.3907 PMC 바로가기
Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1Article Published on 2022-10-182022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ABCE1 abort acute respiratory syndrome affecting AKT Alzheimer’s disease autophagy biochemical analysis combating condition coronavirus COVID-19 pandemic Critical disease Diseases Drosophila effective exhibited Factors Genetic Host hosts mechanism modify neurodegenerative nonstructural protein 1 nsp1 overexpression pathogenic mechanism phenotype prevention Protein Quality control quality-control rescued Research ribosome collision ribosome-associated quality control. ribosomes SARS-CoV-2 Signaling specificity therapeutic strategy translation Treatment virus [DOI] 10.1073/pnas.2202322119 PMC 바로가기
Computational methods and strategies for combating COVID-19Editorial Published on 2022-10-012022-10-05 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] combating COVID-19 [DOI] 10.1016/j.ymeth.2022.08.011 [Article Type] Editorial
Factors Associated With COVID-19 Vaccine Response in Transplant Recipients: A Systematic Review and Meta-analysisArticle Published on 2022-10-012022-11-15 Journal: Transplantation [Category] 진단, [키워드] 95% CI 95% confidence interval age Allogeneic calcineurin Cell combating Comorbidity coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccines dose Effects Factor General population healthy control higher risk humoral Immunocompromised Immunosuppressant immunosuppressive inclusion criteria increased risk inhibitor inhibitors mammalian medication Meta-analysis much lower Organ transplant outcome pandemic performed pooled rate Population Rapamycin receiving recipient recipients regimen response review risk factor second dose Seroconversion seroconversion failure Steroids systematic review the vaccine Transplant Vaccine vaccine response [DOI] 10.1097/TP.0000000000004256 PMC 바로가기