A Chatbot to Support Young People During the COVID-19 Pandemic in New Zealand: Evaluation of the Real-World Rollout of an Open TrialArticle Published on 2022-11-042022-11-15 Journal: Journal of Medical Internet Research [Category] 치료제, [키워드] Adolescent mental health age Anxiety chatbot chatbots cognitive commenced Community connection COVID-19 detect dialog-based intervention digital mental health feasibility feedback flexible help highlight implementation initial iterative lockdown maintain management Mental mental health New online questionnaire open trial Positive psychology Support therapy trial infrastructure Youth [DOI] 10.2196/38743 PMC 바로가기
Structural investigations of proteins encoded by SARS-CoV-2Article Published on 2022-09-012022-11-16 Journal: FEBS Open Bio [Category] SARS, 변종, 유전자 메커니즘, [키워드] antibodies articles bases categories cellular cleaved commenced coronavirus COVID COVID-19 pandemic cysteine proteases described ENCODE Evolution example expressed Final Genome include knowledge MN908947.3 molecular mechanism other coronaviruses pandemic polyprotein positive-sense Protein protein structure purified reported Research ribonuclease RNA genome RNAs SARS-CoV-2 selected sequenced single-stranded small molecule drugs Spike protein structural property the disease the spike protein translation Vaccines variant viral transcript were expressed [DOI] 10.1002/2211-5463.13465 PMC 바로가기
Randomised trial to determine the effect of vitamin D and zinc supplementation for improving treatment outcomes among patients with COVID-19 in India: trial protocolArticle Published on 2022-08-292022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] all-cause mortality assisted ventilation baseline Biomarker Blood clinical trials commenced cough COVID-19 daily dose deficiency defined determine double-blind dysregulated Ethical approval ethical committee Ethics evaluate the effect Fever Final Follow-up hospital Hospital stay host responses India individual symptom Measures Micronutrient Mumbai nutrition occur outcome outcomes participant patients with COVID-19 peer-reviewed Placebo placebo-controlled trial positive individual preventive measure Primary outcome provided randomised recruited recruitment SARS-COV-2 infection secondary Shortness of breath Symptom Time to recovery Treatment outcome Trial trial protocol undergo vaccination was obtained zinc supplementation [DOI] 10.1136/bmjopen-2022-061301 PMC 바로가기 [Article Type] Article
Compassionate use of Pulmonary Vasodilators in Acute Severe Hypoxic Respiratory Failure due to COVID-19COVID-19로 인한 급성 중증 저산소성 호흡부전에서 폐혈관 확장제의 자비로운 사용Article Published on 2022-08-012022-09-11 Journal: Journal of Intensive Care Medicine [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute hypoxic respiratory failure Adult patients analysed ARDS changes in Cohort cohort of patient collected data commenced COVID-19 death Evidence failure feasible Gradient hospital hypoxaemia hypoxic respiratory failure ICU ICU admission Iloprost implementation Inhaled intensive care intensive care unit lack less median nitric oxide non-survivor Non-survivors offer outcome Oxygenation PaO Patient patients with COVID-19 patients with SARS-CoV-2 PF ratio Potential treatment Primary outcome protocol pulmonary Pulmonary vasodilators. randomised receiving reduction in respiratory Respiratory failure robust severe COVID-19 significantly study period Support survivor the median therapeutic option therapeutic options therapy trials vasodilator [DOI] 10.1177/08850666221086521 PMC 바로가기 [Article Type] Article
Treatment of COVID-19 Acute Respiratory Distress Syndrome With a Tabletop Noninvasive Ventilation Device in a Respiratory Intermediate Care UnitResearch article Published on 2022-06-012022-10-05 Journal: Mayo Clinic Proceedings: Innovations, Quality & Outcomes [Category] 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome added Administered age ARDSacute respiratory distress syndrome benefit bilevel positive airway pressure BPAPbilevel positive airway pressure CARDScoronavirus disease 2019 acute respiratory distress syndrome Care Cohort commenced Comorbidities Continuous Positive Airway Pressure coronavirus disease coronavirus disease 19 coronavirus disease 2019 acute respiratory distress syndrome COVID-19 COVID-19coronavirus disease 19 CPAPcontinuous positive airway pressure death defined Device effective Escalation HFNOhigh-flow nasal oxygen High-flow nasal oxygen hospital hospitalized patient hypertension ICUIntensive Care Unit IMVInvasive mechanical ventilation India inspiratory positive airway pressure intensive care intensive care unit intermediate intubation Invasive mechanical ventilation IPAPinspiratory positive airway pressure low-flow oxygen management men NIV NIVnoninvasive ventilation Noninvasive ventilation objective outcome Patient PEEPpositive end-expiratory pressure positive positive airway pressure Positive end-expiratory pressure required resources respiratory respiratory intermediate care unit Respiratory Support Result RIMCUrespiratory intermediate care unit study period Support syndrome therapy treated Treatment unit [DOI] 10.1016/j.mayocpiqo.2022.04.001 [Article Type] Research article
Does exercise influence burn-induced inflammation: A cross-over randomised controlled feasibility trialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] Burn chronic inflammation clinical trial commenced Completeness conditions Conducting control condition COVID COVID-19 COVID-19 pandemic cross-over described determine eligible participant end point exercise feasibility feasible greater healthy help hospital implementation IMPROVE individual Inflammation Inflammatory response initial initiated Injury insight knowledge measure methodology outcome participant patients pilot study populations randomised randomised controlled recruited Research researcher Seven shown total body trauma Trial [DOI] 10.1371/journal.pone.0266400 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys영국의 SARS-CoV-2 감염 및 백신 효과(REACT-1): 일련의 횡단면 무작위 커뮤니티 설문조사Article Published on 2022-04-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI adjusted Administered Adults age assessment B.1.617.2 BNT162b2 Breakthrough infection breakthrough infections ChAdOx1 ChAdOx1 nCoV-19 children commenced Community community transmission contributed COVID-19 epidemic COVID-19 vaccine CrI cross-sectional cross-sectional survey Data collection declined delta variant Department dose driving Effectiveness England General population highest household size increased risk individual individuals Infection less Mutation nose swab Older Oxford-AstraZeneca participant Pfizer-BioNTech positive Prevalence random reduce Reproduction number risk RT-PCR SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection SARS-CoV-2 transmission second dose sequenced single dose Spike protein Spread Swab swabs the spike protein vaccination vaccination rate vaccination rates Vaccine vaccines combined variant [DOI] 10.1016/S2213-2600(21)00542-7 PMC 바로가기 [Article Type] Article
The UK stand together trial: protocol for a multicentre cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of KiVa to reduce bullying in primary schoolsUK Stand Together Trial: 초등학교에서 괴롭힘을 줄이기 위한 KiVa의 효과와 비용 효율성을 평가하기 위한 다기관 클러스터 무작위 통제 시험 프로토콜Article Published on 2022-03-292022-09-11 Journal: BMC Public Health [Category] 임상, [키워드] 1:1 90% power Analysis assigned assumed baseline Bullying Burnout bystander Child child health children client Cluster Cluster randomised controlled trial commenced conducted Controlled trial cost-effectiveness COVID-19 pandemic Date East Economic evaluation effective Effectiveness emotional England evaluate Evidence evidence of Follow-up Frequency generate Health ICC identify implementation indicated influences influences on Intervention inventory ISRCTN KiVa mechanisms Mental mental health multicentre North Perspective Pragmatic Process process evaluation protocol public health questionnaire randomised randomised controlled randomised controlled trial receipt recruited reduce reducing reduction reported resulting Sample Sample size scalability School school attendance School intervention School meal Schools secondary Self-efficacy service significance level South stratified Trial Two-arm Violence prevention Violence prevention. Well-being West [DOI] 10.1186/s12889-022-12642-x PMC 바로가기 [Article Type] Article
Randomized, Double Blind, Placebo Controlled, Clinical Trial to Study Ashwagandha Administration in Participants Vaccinated Against COVID-19 on Safety, Immunogenicity, and Protection With COVID-19 Vaccine–A Study ProtocolMedicine Published on 2022-02-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] administration Against All adverse event antibody titres approval Ashwagandha Ayurveda benefit clinical commenced Controlled COVID-19 COVID-19 infection COVID-19 vaccine double-blind effective Ethics exploratory study healthy volunteer immunoadjuvant immunogenicity immunological India Indian people interim analysis margin Measures Medicine National offered outcome measure Oxford-AstraZeneca parallel-group participant peer-reviewed placebo-controlled populations power calculation protection protective immune response Quality of life Randomized RBD-specific IgG receiving recruited recruitment regimen Registration reported Result Safety SARS-CoV-2 spike second dose secondary Two-arm vaccinated against COVID-19 vaccination Vaccine was obtained Withania somnifera [DOI] 10.3389/fmed.2022.761655 PMC 바로가기 [Article Type] Medicine
Anxiety Linked to COVID-19: A Systematic Review Comparing Anxiety Rates in Different PopulationsReview Published on 2022-02-152022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Anxiety association CINAHL commenced conditions conducted contributed COVID-19 COVID-19 pandemic database English excluded Factor female General population group healthcare worker highest identify Impact Infection Mental mental health pandemic parent Population populations pregnant women Prevalence PsycINFO qualitative systematic review Rate restriction review risk factor Sample size systematic review utilised worsened [DOI] 10.3390/ijerph19042189 PMC 바로가기 [Article Type] Review