Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial간질 세포 투여에 의한 급성 호흡 곤란 증후군의 회복(REALIST): 공개 라벨 용량 증량 1상 시험에 이어 무작위, 삼중 맹검, 할당 은폐, 위약 대조 2상 시험을 위한 구조화된 연구 프로토콜Article Published on 2022-05-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 acute respiratory distress acute respiratory distress syndrome administration allocation ARDS benefit blind causes Cell cells clinical clinical trial Cohort cohort of patient cohorts of patients concealed CONSORT COVID-19 distress dose dose-escalation early stage early stages Efficacy EudraCT Good immunomodulatory incidence include Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells moderate to severe MSC MSCs multicentre NHS number Open-label outcome outlined oxygenation index patients patients with moderate Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled placebo-controlled trial Practice produced protocol randomised rationale receive recruited recruitment repair reported Reporting respiratory distress Respiratory distress syndrome Serious Adverse Events severe ARDS Standard stromal cell stromal cells Study protocol syndrome therapy Trial triple-blind umbilical Umbilical cord [DOI] 10.1186/s13063-022-06220-0 PMC 바로가기 [Article Type] Article
Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trialClinical Trial Published on 2022-04-012022-10-05 Journal: The Lancet. Haematology [Category] Fulltext, MERS, 임상, [키워드] 1:1 absence acute respiratory distress adjusted adjusted relative risk Administered adverse event age assigned average benefit Blood blood product Care caused characteristics of patient clearance Complication concealed COVID-19 pandemic Critical care deaths defined eligibility Follow-up identify Injury intention-to-treat population intravenous investigated involved IQR Lactate Liver function male median median age Mortality multicentre nine occurred Open-label outcome parallel group participant participants randomly assigned Patient phase 3 trial plasma Primary outcome pulse randomisation randomised Randomly receive receiving recruitment red blood cell reducing mortality Registered remains uncertain required Research Resuscitation risk Sample size Serious Adverse Events severity Shock Sodium chloride stratified syndrome Systolic blood pressure time tissue trauma Treatment treatment group Trial were assessed [DOI] 10.1016/S2352-3026(22)00040-0 PMC 바로가기 [Article Type] Clinical Trial
Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)—trial protocol급성 호흡 곤란 증후군에서 환기를 평가하기 위한 의사 결정 지원 시스템(DeVENT 연구) - 시험 프로토콜Study Protocol Published on 2022-01-172022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome allocation approach ARDS ARDS patient ARDS patients clinical decision clinical trial complex concealed contribute Course COVID-19 COVID-19 pandemic Critical care Decision support decision support system decision support systems decrease decreases determine determined by driving End-Expiratory Pressure evaluate facilitate help IMPROVE improvement International Local lung Lung injury management mathematical Mathematical models mechanical ventilation Mechanical ventilation; Acute respiratory distress syndrome mechanically ventilated mechanically ventilated patient mechanically ventilated patients Mitigation morbidity morbidity and mortality Mortality occur open outcome pandemic Pandemics Patient patients PEEP personalised physiological state point-of-care Positive end-expiratory pressure Pragmatic pressure protective effect Protective effects protocol randomised reduction in respiratory distress Respiratory distress syndrome routine care severity supplementary material Support Support System syndrome variety ventilated patient ventilated patients Ventilation ventilator Ventilator-induced lung injury ventilatory strategy [DOI] 10.1186/s13063-021-05967-2 PMC 바로가기 [Article Type] Study Protocol
ENhAncing Lifestyle Behaviors in EndometriaL CancEr (ENABLE): A Pilot Randomized Controlled TrialRandomized Controlled Trial Published on 2022-01-012022-10-05 Journal: Integrative cancer therapies [Category] SARS, 임상, [키워드] adherence age Behavior BMI Cancer concealed Controlled Controlled trial COVID-19 declined disease disease stage eligible patient Endometrial Cancer feasibility Health highest impacted Intervention intervention group majority measure nutrition occurred online questionnaire participant physical physical activity Randomized RCT recruited recruitment Registered retention Serious Adverse Event Support telehealth Treatment Trial usual care usual care alone [DOI] 10.1177/15347354211069885 PMC 바로가기 [Article Type] Randomized Controlled Trial
A rapid lateral flow immunoassay strip for detection of SARS‐CoV‐2 antigen using latex microspheresResearch Article Published on 2021-11-062022-10-30 Journal: Journal of Clinical Laboratory Analysis [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition age analyzed antibody Antigen antigen detection antigens applicability Bacterial infections cause clinical manifestation concealed conditions coronavirus COVID‐19 death decrease Detection limit Diagnosis diagnostic tests Dilution disadvantage disease stage EDC and NHS Efficiency Epidemic evaluated fixed Gender immune IMPROVE lateral flow immunoassay latex microspheres LFIA limit of detection Measures microsphere MOST offer Pneumonia point‐of‐care positive provide quarantine reproducibility Result SARS‐CoV‐2 SARS‐CoV‐2 antigen sensitivity Sensitivity and specificity specificity specimens stability tested the epidemic Vaccine virus visual method was determined was tested was used [DOI] 10.1002/jcla.24091 PMC 바로가기 [Article Type] Research Article
Behavioural activation to prevent depression and loneliness among socially isolated older people with long-term conditions: The BASIL COVID-19 pilot randomised controlled trialRandomized Controlled Trial Published on 2021-10-122022-10-04 Journal: PLoS Medicine [Category] MERS, SARS, 임상, [키워드] 1.26 95% CI Activation adjusted Adults adverse events age AMD Anxiety approach approaches assessment baseline behavioural benefit blind collected comparison concealed conditions confidence interval covariate COVID-19 COVID-19 pandemic demonstrated Depression depressive symptom Depressive symptoms Effect effective Effectiveness emotional Evidence examined feasible female Follow-up form GAD groups Health impacted Infection Intervention Isolation limitations loneliness Long-term condition LTC LTCs mean difference median Mental mitigate occurred offered Older outcome pandemic participant PHQ-9 physical pilot study populations preliminary finding Prevent primary care primary clinical outcome Primary outcome PROTECT Psychological psychological Impact Quality of life randomised randomised controlled trial Randomised trial RCT receiving recruited recruitment reduced reduction in remote replicate Replication researcher risk robust scale second secondary outcome severity shown social isolation Standard deviation Statistical power Support tested the median treatment allocation Trial turn Type unlikely was measured white [DOI] 10.1371/journal.pmed.1003779 PMC 바로가기 [Article Type] Randomized Controlled Trial
Adjunctive inspiratory muscle training for patients with COVID-19 (COVIDIMT): protocol for randomised controlled double-blind trialCOVID-19 환자를 위한 보조 흡기 근육 훈련(COVIDIMT): 무작위 대조 이중 맹검 시험 프로토콜Article Published on 2021-09-222022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] added addition advanced age analysed analysis of variance Anxiety approach approval approved baseline Brazil Comorbidities Comorbidity concealed COVID-19 Depression determine double-blind trial Dyspnoea Effect effective Ethics Exercise capacity fatigue impairment IMPROVE inspiratory muscle life National Ethics Committee obesity Organ failure outcome Pain parallel-group participant patients with COVID-19 peer-reviewed physical Primary outcome protocol public health Pulmonary function pulmonary rehabilitation Quality of life raising randomised randomised controlled randomised controlled trial receive recruited registration number rehabilitation rehabilitation medicine study groups symptomatic patient Symptomatic patients Symptoms the study group Traditional treatment effects Trial variance [DOI] 10.1136/bmjopen-2021-049545 PMC 바로가기 [Article Type] Article
Low-Dose Radiation Therapy for Severe COVID-19 Pneumonia: A Randomized Double-Blind StudyRandomized Controlled Trial Published on 2021-08-012022-10-04 Journal: International journal of radiation oncology, biolo [Category] 임상, [키워드] 95% confidence interval Analysis Arm ARMS changes in Clinicians concealed coronavirus disease COVID-19 Critically ill patient double-blind study Endpoint group groups improve clinical outcome inflammatory markers intensive care low-dose Lymphocyte count mechanical ventilation median median age morbidity and mortality no significant difference overall survival Oxygenation Patient patient cohort Pneumonia postintervention radiation therapy Randomized reduction in secondary secondary endpoint Standard of care survival the primary endpoint treated patient ventilator-free day [DOI] 10.1016/j.ijrobp.2021.02.054 PMC 바로가기 [Article Type] Randomized Controlled Trial
Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trialRandomized Controlled Trial Published on 2021-07-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] 임상, [키워드] 1:1 95% CI Adsorption analysed assigned benefit center clinical computer-generated concealed Concentration connection control group Controlled trial COVID-19 cytokine did not reduce died ECMO eligibility Endpoint extracorporeal membrane oxygenation Germany IL-6 intention to treat interleukin-6 log one patient Open-label Patient patients with COVID-19 primary endpoint randomised Randomly receive Registered replaced sealed secondary selected serum severe COVID-19 Severe COVID-19 pneumonia Support supported survival the patient treated Trial university with COVID-19 [DOI] 10.1016/S2213-2600(21)00177-6 PMC 바로가기 [Article Type] Randomized Controlled Trial
Emotional exhaustion in front-line healthcare workers during the COVID-19 pandemic in Wuhan, China: the effects of time pressure, social sharing and cognitive appraisalResearch Published on 2021-04-302022-10-28 Journal: BMC Public Health [Category] Coronavirus, MERS, SARS, [키워드] Analysis China Cognition cognitive concealed conducted COVID-19 COVID-19 pandemic cross-sectional determine Effect Emotional exhaustion healthcare healthcare worker Healthcare workers influence Linear regression mental fatigue objective Occupational stress performed positive questionnaire Result Social support spread of COVID-19 time Wuhan [DOI] 10.1186/s12889-021-10891-w PMC 바로가기 [Article Type] Research