Machine learning-based prediction of sertraline concentration in patients with depression through therapeutic drug monitoringPharmacology Original Research Published on 2024-03-062024-09-05 Journal: Frontiers in Pharmacology [Category] update2024, [키워드] concentrations machine learning sertraline Therapeutic Drug Monitoring XGBoost [DOI] 10.3389/fphar.2024.1289673 PMC 바로가기 [Article Type] Pharmacology Original Research
The inhibitory activity of methoxyl flavonoids derived from Inula britannica flowers on SARS-CoV-2 3CLproArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro concentrations coronavirus effective effort exhibited flavonoid HCoV-OC43 Hydrogen bond identify inhibited inhibitor inhibitory activity Inula britannica key amino acid Methoxyl flavonoids molecular simulations natural antiviral nuclear proliferation SARS- CoV-2 SARS-CoV-2 Structure suppressed [DOI] 10.1016/j.ijbiomac.2022.10.008 PMC 바로가기
Short-term exposure of the mayfly larvae (Cloeon dipterum, Ephemeroptera: Baetidae) to SARS-CoV-2-derived peptides and other emerging pollutants: A new threat for the aquatic environmentsArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] SARS, 바이오마커, [키워드] acetylcholinesterase addition ambient aquatic environment aquatic environments Biomarker Biomarkers Cloeon Combination concentrations coronavirus dismutase DPPH ecosystem Effect evaluate evidenced Freshwater ecosystems groups hospital Impact Insects Mortality New coronavirus nitrite Non-target organisms novel Novel coronavirus organism Organisms PCA peptide peptides principal component analysis raised reduced response risk SARS-CoV-2 scavenging significantly lower similarity Spread Stress Topic Treatment viral peptide [DOI] 10.1016/j.scitotenv.2022.157813 PMC 바로가기
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cellsArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals approved drug caused clinical evaluation Combination Compound concentrations conducted COVID-19 drug Effect Efficacy epithelial cell line exonuclease global pandemic HCV hepatitis C human lung human lung cell identify inhibitor moderate morbidity Mortality NS5A pharmacokinetic profiles Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication Support synergy the SARS-CoV-2 therapeutic treatment strategy virus [DOI] 10.1038/s41598-022-21034-5 PMC 바로가기
An external quality assessment for the molecular testing of the SARS-CoV-2 virus genome in Zhejiang Province, ChinaArticle Published on 2022-11-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy Asymptomatic CDC China Combination Concentration concentrations Concordance COVID-19 COVID-19 pandemic Culture diagnostics external quality assessment false-negative False-positive Genome infected individual Laboratory medium molecular molecular diagnostics negative sample nucleic acid extraction organized participated PCR Population positive sample provide public health rapid expansion reagents SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 tests serial dilution the SARS-CoV-2 virus viral titer Zhejiang [DOI] 10.1016/j.diagmicrobio.2022.115766 PMC 바로가기
Exploratory analysis of interleukin-38 in hospitalized COVID-19 patientsArticle Published on 2022-11-012022-11-15 Journal: Immunity, Inflammation and Disease [Category] SARS, 바이오마커, [키워드] Adaptive immune response Admission age Analysis anti-inflammatory effect anti-inflammatory properties binding Biomarker cartilage CD244 CHL1 circulating Clinical data Cohort cohorts Concentration concentrations coronavirus disease correlated correlation COVID-19 COVID-19 patient COVID-19 severity disease dismutase dysregulated enzyme-linked immunosorbent exploratory fatty healthy control healthy controls healthy subjects hospital Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 Immunoglobulin in viral increase in infections Inflammatory biomarker intensive care interleukin-38 investigated men moderate Mortality no difference outcome plasma positive correlation positively correlated progression Protein proximity extension assay recent receptor reduce retrieved retrospective cohort study SARS-CoV-2 SERPINA12 severity shown subjects thrombocyte TNF TNFRSF9 validation cohort were measured while women [DOI] 10.1002/iid3.712 PMC 바로가기
Chemical explosion, COVID-19, and environmental justice: Insights from low-cost air quality sensorsResearch article Published on 2022-11-012022-10-05 Journal: The Science of the total environment [Category] 유전자 메커니즘, [키워드] addition affecting Air quality monitoring Analysis anthropogenic association Chemical Community company comparable Concentration concentrations COVID-19 Critical disaster environmental justice EPA examined finding greater Houston identify indicate Industrial fire accident information insight ITC lockdown Low-cost sensor measure MONITOR monitors objective observation Particulate matter positive protection Regulatory Sociodemographic terminal Variation [DOI] 10.1016/j.scitotenv.2022.157881 [Article Type] Research article
Observational Study of Receptor Binding Domain Spike Antibody Responses to 3 SARS-CoV-2 Vaccinations in Noninfected Subjects: Parallel Neutralizing Antibody and Cardiac Troponin I and T ObservationsArticle Published on 2022-10-292022-11-15 Journal: The journal of applied laboratory medicine [Category] COVID19(2023년), SARS, 진단, [키워드] antibody Biotechnology blood specimen cardiac cardiac troponin change collected Concentration concentrations Decline dose doses Effectiveness ET Healthcare increase janssen kinetic Moderna myocardial injury Neutralizing observation Pfizer platform point-of-care postvaccination Protein Pylon 3D RBD Receptor binding domain response SARS-CoV-2 seronegative specimens spike subject subjects troponin vaccination Vaccinations Vaccine were measured [DOI] 10.1093/jalm/jfac053 PMC 바로가기
Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain InhibitorsArticle Published on 2022-10-202022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Algorithm Alpha variant bind binding binding affinity candidate caused Concentration concentrations COVID-19 pandemic demonstrated disrupt domain ELISA assays entry of SARS-CoV-2 experiments expressed globe host cells human cells inhibitory initial insoluble Interaction moderate Molecular dynamics simulation molecule peptidase peptide Prevent Protein RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2-RBD sequence spike the RBD the SARS-CoV-2 therapeutic These data validation variants virus entry was used Wuhan-Hu-1 α1 helix [DOI] 10.1021/acs.jpcb.2c03918 PMC 바로가기
Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19Article Published on 2022-10-192022-11-15 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI Administered administration Adverse affected analysed antiviral therapy Antiviral treatment ARMS baseline changed Combination combination therapy concentrations conducted coronavirus 2 COVID-19 COVID-19 pandemic Day Dose escalation doses double-blind double-blind trial drug level effective Efficacy evaluate the effect event Favipiravir healthy Interaction Lopinavir-ritonavir measure monotherapy Odds ratio Outpatient participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial placebos plasma primary analysis Primary outcome provided randomised recruited reduced respiratory SARS-CoV-2 SARS-CoV-2 viral load significant interaction significantly study population symptom onset the mean trajectory Treatment undetectable United Kingdom Viral load virus [DOI] 10.1371/journal.pmed.1004120 PMC 바로가기