concomitant use – Communicable Diseases Research

Clinical Characteristics of COVID-19: Use of Steroids in Mostly Unvaccinated COVID-19 Patients Before the Omicron Variant

COVID-19의 임상적 특징: Omicron 변이 이전에 대부분 백신을 접종하지 않은 COVID-19 환자에서 스테로이드 사용

Article

Published on 2022-07-252022-09-11
Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종,

Predicting Impact of Prone Position on Oxygenation in Mechanically Ventilated Patients with COVID-19

Observational Study

Published on 2022-07-012022-10-04
Journal: Journal of Intensive Care Medicine [Category] Coronavirus, 임상,

Drug interaction risk between cardioprotective drugs and drugs used in treatment of COVID-19: A evidence-based review from six databases

심장 보호 약물과 COVID-19 치료에 사용되는 약물 간의 약물 상호 작용 위험: 6개 데이터베이스의 증거 기반 검토

Review

Published on 2022-03-012022-09-11
Journal: Diabetes & metabolic syndrome [Category] SARS, 변종, 신약개발, 치료법, 치료제,

[키워드] acting antihypertensive drugs approved Atazanavir Azithromycin cardiovascular system caution Chloroquine close monitoring comorbid condition comorbid conditions Comorbidity concomitant use COVID COVID- 19 treatment COVID-19 COVID-19 infection COVID-19 treatment database Dexamethasone diabetes dosage drug drug interaction drug-drug interaction drugs Effect Effects ENhance Evidence Factor FDA glycemic control group hypertension Hypotension Improving Infection information Interaction interaction effect life Lopinavir Lopinavir/ritonavir Medicine Medscape molnupiravir monoclonal antibodies monoclonal antibody Nirmatrelvir Patient Paxlovid polypharmacy Potential Quality of life Remdesivir resulting review risk Ritonavir therapeutic efficacy therapy treating COVID-19 Treatment worsening
[DOI] 10.1016/j.dsx.2022.102451 PMC 바로가기 [Article Type] Review

Induction of CD73 prevents death after emergency open aortic surgery for a ruptured abdominal aortic aneurysm: a randomized, double-blind, placebo-controlled study

Article

Published on 2022-02-032022-10-04
Journal: Scientific Reports [Category] 바이오마커,

[키워드] 95% CI adverse event all-cause mortality Analysis Aneurysm anticipated aortic aneurysm ARDS baseline blocked with CD73 cluster of differentiation concerning concomitant use congestive heart failure D30 death demonstrated diagnosed double-blind drug-drug interaction Efficacy and safety exclusion criteria glucocorticoid Hemorrhagic IFN IMPROVE induction initial interim analysis intestinal intravenous Ischemia Liver cirrhosis Major malignant disease matching placebo mechanism Neutralizing antibodies neutralizing antibody outcome outcome measure parallel group Patient Placebo placebo-controlled study postoperative Prevent Pyrexia Randomized randomized patient Registered renal replacement therapy reported serum Shock statistically significant difference suggested surgery survival survived treated Treatment treatment group Trial up-regulating
[DOI] 10.1038/s41598-022-05771-1 PMC 바로가기 [Article Type] Article

Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19

Observational Study

Published on 2022-01-012022-10-05
Journal: Science progress [Category] SARS, 임상,

[키워드] 95%CI acute respiratory distress added Administered Admission Analysis Anti-inflammatory antioxidant ARDS association baseline baseline characteristics Care Comorbidity concomitant use conditions conducted COPD coronavirus disease Corticosteroids COVID-19 COVID-19 patient Cytokine storm diabetes diagnosis of COVID-19 doses duration of hospitalization Electronic health record greater Health services High dose Hospitalized hospitalized COVID-19 hypertension information intensive care Invasive mechanical ventilation life-threatening male Mortality N-acetylcysteine NAC no significant difference Older outcome oxidative stress Patient patients hospitalized PCR Population potential benefit pro-thrombotic Randomized controlled trials remained retrospective cohort study risk SARS-CoV-2 Signaling significantly lower Spain Standard of care syndrome the mean treated Treatment use of health services. with COVID-19
[DOI] 10.1177/00368504221074574 PMC 바로가기 [Article Type] Observational Study

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

TMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다

Research Article

Published on 2021-11-222022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses
[DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article

Polypharmacy among COVID-19 patients: A systematic review

Review article

Published on 2021-09-012022-10-05
Journal: Journal of the American Pharmacists Association : [Category] SARS, 신약개발,

[키워드] 95% CI Acute kidney injury adopted Adverse drug reaction antipsychotic article association Care China Clinical outcome Combination concomitant use condition conducted coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 positive patient database death Diseases drug ENhance Google Scholar IMPROVE inclusion criteria increase in increased risk individual item knowledge male medications men morbidity National objective Older Patient patients PMC polypharmacy positive positive COVID-19 prevalent PubMed Central Reporting Result review risk risk stratification selected severe COVID-19 systematic review total sample size understanding unique were used women
[DOI] 10.1016/j.japh.2021.05.006 [Article Type] Review article

Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context

COVID-19 환자의 인터루킨-6 수용체 차단: 상황에 따른 임상 시험 적용

Review

Published on 2021-06-012022-09-11
Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 임상, 진단,

[키워드] acute respiratory illness binding blockade Characteristics clinical and methodological heterogeneity clinical decision clinical trial concomitant use contributed Corticosteroid Corticosteroids cytokine Decision making Efficacy and safety enrichment Evidence Factor heterogeneity IL-6 IL-6 receptor antagonists implicated interleukin-6 measurement scales methodological outcome Pathogenesis pathogenesis of COVID-19 Patient patients pleiotropic potential benefit potential benefits randomised randomised trials receptor receptor antagonists reported respiratory sarilumab Sery severity severity of illness tested the disease Tocilizumab Treatment treatment effects Trial trials Variability
[DOI] 10.1016/S2213-2600(21)00139-9 PMC 바로가기 [Article Type] Review

Effect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis

Systematic Review

Published on 2021-05-132022-10-30
Journal: Journal of Cardiovascular Development and Disease [Category] COVID-19,

Clinically Significant Drug Interactions Between Psychotropic Agents and Repurposed COVID-19 Therapies

향정신성 제제와 용도 변경 COVID-19 치료제 간의 임상적으로 중요한 약물 상호작용

Review

Published on 2021-04-012022-09-11
Journal: CNS drugs [Category] MERS, 신약개발, 유전자 메커니즘, 치료제,