Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerabilityArticle Published on 2022-09-012022-11-15 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Analysis antibodies antibody beta-coronavirus beta-coronaviruses Broadly neutralizing antibody conformations conserved coronavirus COVID-19 crystal structure elicit hydrophobic residue immunized indicated inhibiting Middle East mRNA murine neutralization neutralize neutralized Neutralizing recognizing S2 subunit S2-directed antibody Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variants spike syndrome the antibody the SARS-CoV-2 Vaccine design [DOI] 10.1016/j.str.2022.06.004 PMC 바로가기
Conformational ensemble of the full-length SARS-CoV-2 nucleocapsid (N) protein based on molecular simulations and SAXS data분자 시뮬레이션 및 SAXS 데이터를 기반으로 한 전장 SARS-CoV-2 뉴클레오캡시드(N) 단백질의 구조적 앙상블Article Published on 2022-09-012022-09-11 Journal: Biophysical chemistry [Category] COVID19(2023년), SARS, 치료법, [키워드] average conditions conformation conformational conformations Contact dimer domain domains Each EROS exhibit experiment fluctuation full-length full-length SARS-CoV-2 gyration hydrophobic intrinsically knowledge Molecular simulation NMR nonspecific nucleocapsid nucleocapsid protein offer Protein radius of gyration Region SARS-CoV-2 SARS-CoV-2 virus SAXS. Structure structures the SARS-CoV-2 virus while X-ray scattering α-helix [DOI] 10.1016/j.bpc.2022.106843 PMC 바로가기 [Article Type] Article
Structure of SARS-CoV-2 membrane protein essential for virus assembly바이러스 조립에 필수적인 SARS-CoV-2 막 단백질의 구조Article Published on 2022-08-052022-09-11 Journal: Nature Communications [Category] SARS, 변종, 치료법, [키워드] Analysis component composed conformational changes conformations conserved coronavirus cryo Cryo-electron microscopy domain domains electron microscopy form hinge region Interaction ion channel M protein mechanism membrane protein morphogenesis nucleocapsid protein oligomers ORF3a Protein recruitment RNA SARS-CoV-2 SARS-CoV-2 ORF3a structural protein Structure the SARS-CoV-2 therapeutic intervention transmembrane virus [DOI] 10.1038/s41467-022-32019-3 PMC 바로가기 [Article Type] Article
Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies자연적으로 유도된 항-SARS-CoV-2 항체에 의한 SARS-CoV-2 중화의 구조적 유연성Article Published on 2022-08-052022-09-11 Journal: Communications Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding site Alpha anti-RBD anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Arm array Beta bind binding conformations convalescent Cross linking cross-neutralizing Culture Delta Donor elicited epitope evaluate exhibit FIVE flexible Gamma likelihood mAb mAbs mechanism molecular monoclonal antibodies monoclonal antibody mutated neutralization neutralize Neutralizing nine omicron Proteins provide pseudoviruses RBD Receptor binding domain recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike trimer SARS-CoV-2 variants Spike protein Spike proteins spike trimer Structure structures subunits tested the RBD the SARS-CoV-2 unique variant variants of concern variants of SARS-CoV-2 Viral viral evolution virus viruses VoC VOCs wild type Wuhan-Hu-1 [DOI] 10.1038/s42003-022-03739-5 PMC 바로가기 [Article Type] Article
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike설계된 이황화물은 잠긴 SARS-CoV-2 스파이크의 구조적 역학을 보여줍니다Article Published on 2022-07-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] Acidic Alter Analysis cellular compartment change changes in conformation conformational change conformations D614G D614G mutation Disulfide disulfide bond domain extracellular space functional high-resolution structure hinge interact modulate Mutation Neutral pre-fusion Protein provide RBD Receptor binding domain Regulation reveal SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spikes sequence Structure structures transition variants of concern viral fitness virion virus wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1010583 PMC 바로가기 [Article Type] Article
Structural Plasticity and Immune Evasion of SARS-CoV-2 Spike VariantsSARS-CoV-2 스파이크 변이체의 구조적 가소성 및 면역 회피Review Published on 2022-06-092022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] accumulated mutation accumulated mutations acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected affecting antibody antibody escape approach atomic binding Care caused cells conformations coronavirus COVID-19 COVID-19 pandemic functions global pandemic Health Health care Health care system Host immune immune evasion Infection Interpretation Limited molecular molecular mechanism mutations parental profiles protective vaccines Protein recent finding recent findings resolved S protein S variant SARS-CoV-2 SARS-CoV-2 variants scientist severe acute respiratory syndrome Coronavirus shifting significantly spike Spike proteins Structure structures therapeutic option Transmissibility Vaccines variants variants of concern virus entry virus transmissibility Virus-host interaction Virus-host interactions VoC VOCs Wuhan-Hu-1 [DOI] 10.3390/v14061255 PMC 바로가기 [Article Type] Review
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Research Published on 2022-06-062022-10-05 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] activated acute respiratory syndrome approach blocked cathepsin Cell cleavage site conformations conserved coronavirus CTSL CTSL cleavage demonstrated domain Effect Ex vivo exhibited experiment host protease human donor Infection inhibitor Live virus lung tissue mechanism membrane fusion mice mutated novel omicron Prevent promoted Protein pseudovirus RBD reduced S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants strain the S protein therapy Treatment treatment strategy Vaccine variant viral infection virus [DOI] 10.1038/s41421-022-00419-w [Article Type] Research
GEOM, energy-annotated molecular conformations for property prediction and molecular generation Research Published on 2022-04-212022-10-05 Journal: Scientific Data [Category] 치료제, [키워드] 3D structure approach assist conformation conformations dataset functional generate machine ML model molecular molecule outperform physical predict property solvent [DOI] 10.1038/s41597-022-01288-4 [Article Type] Research
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617B.1.617에 대한 효능을 유지하는 단일특이성 및 이중특이성 단일클론 SARS-CoV-2 중화 항체Article Published on 2022-03-282022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibody B cell B cells B.1.617 B.1.617.2 binding patterns Breakthrough infection breakthrough infections caused clone complex conformations COVID-19 Critical cryo-EM structure cryo-EM structures death delta variant ectodomain Efficacy Epitopes expand facilitate functional generate humanized identify immunized in vivo inhibitory activity lead mAb mAbs maintain monoclonal monoclonal antibodies monoclonal antibody nanomolar affinity neutralize Neutralizing Neutralizing antibodies neutralizing antibody occur pathogen prefusion Prophylactic RBD Receptor binding domain repertoire SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants single cell sequencing Spike receptor binding domain spike trimer therapeutic therapeutic option Therapeutics translation Vaccine variants variants of concern virus [DOI] 10.1038/s41467-022-29288-3 PMC 바로가기 [Article Type] Article
Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomainSARS-CoV-2 오미크론 스파이크 단백질 엑토도메인의 Cryo-EM 구조Article Published on 2022-03-032022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] cell entry conformations Critical cryo-EM structure ectodomain globe immune immune evasion immune surveillance mechanism mixture Mutation Neutralizing antibodies neutralizing antibody Omicron variant open RBD RBD region Receptor binding Receptor-binding domain SARS-CoV-2 Spike protein standing up Surveillance the cell the receptor-binding domain the spike protein viral strain [DOI] 10.1038/s41467-022-28882-9 PMC 바로가기 [Article Type] Article