Shigella Vaccines: The Continuing Unmet Challenge시겔라 백신: 계속되는 해결되지 않은 도전Article Published on 2024-04-132024-08-22 Journal: International Journal of Molecular Sciences [Category] 세균성이질, [키워드] conjugate live attenuated Shigella spp Shigellosis subunit type III secretion system Vaccines whole killed.
Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry시겔라 플렉스네리 2a 및 S. 플렉스네리 3a를 겨냥한 시겔라 접합 백신 개발: 스쿼릭산 화학을 이용한 간단한 플랫폼 접근 방식 접합.Article Published on 2023-07-312024-08-22 Journal: Vaccine [Category] 세균성이질, [키워드] conjugate Immunity S. flexneri 2a S. flexneri 3a Shigella Shigellosis Squaric acid Vaccine [DOI] 10.1016/j.vaccine.2023.06.052
Pneumococcal carriage following PCV13 delivered as one primary and one booster dose (1 + 1) compared to two primary doses and a booster (2 + 1) in UK infantsPCV13을 1회 기본 접종과 1회 추가 접종(1 + 1)으로 시행한 후의 폐렴구균 보유율을 두 회 기본 접종과 1회 추가 접종(2 + 1)과 비교한 영국 유아에서의 결과Article Published on 2023-05-052024-08-24 Journal: Vaccine [Category] 폐렴구균 감염증, [키워드] conjugate Infant schedules Vaccine Pneumococcal. [DOI] 10.1016/j.vaccine.2023.04.017
An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force유전영동력을 통한 센서 성능 수정 및 COVID-19 혈청학 테스트를 위한 방해계 바이오센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-S antibody antibody Antibody detection Antibody test assistance AuNP binding buffer causative agent caused Concentration conjugate coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 antibody COVID-19 serology test described detect Dielectrophoresis force digit faster gold Gold interdigitated electrodes Gold nanoparticles human sera IDE immunization impedance Impedimetric biosensor. limit of detection Modification morbidity and mortality non-specific phenomenon point-of-care solution Protein purified reached responses SARS-CoV-2 secondary antibody sensitivity sensor sera serology serology test serology tests serum severe acute respiratory syndrome Coronavirus Spectroscopy spike the disease therapeutic time-consuming [DOI] 10.1016/j.bios.2022.114476 PMC 바로가기 [Article Type] Article
Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteriaArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] active against Affect Antibiotics antimicrobial Antiviral approved Bacteria Bacterial cells Co-infection Compound conjugate coronavirus derivative drug drugs effective Efficacy Endemic endosomal entry enzyme HCoV-229E human Calu-3 cell hydrophobic infected with SARS-CoV-2 inhibiting inhibition assay inhibitor membrane modifications Prevent Prognosis risk RNA virus SARS-CoV-2 SARS-CoV-2 replication Seven shown VeroE6 cells [DOI] 10.1038/s41598-022-20182-y PMC 바로가기
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization ApproachArticle Published on 2022-09-122022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] agent antiviral property approach computational studies conjugate Conjugates cytotoxicity healthcare hybridization indole investigated molecular Molecular modeling Potential quinoline rhodanine. SAR-CoV-2 SARS-CoV-2 small molecule synthesis virus [DOI] 10.3390/molecules27185923 PMC 바로가기
Drug Repurposing by Siderophore Conjugation: Synthesis and Biological Evaluation of Siderophore-Methotrexate Conjugates as Antibiotics철분 운반체 결합에 의한 약물 재목적화: 항생제로서의 철분 운반체-메토트렉세이트 결합체의 합성 및 생물학적 평가Article Published on 2022-09-052024-08-24 Journal: Angewandte Chemie (International Ed. in English) [Category] 폐렴구균 감염증, [키워드] Antimicrobials conjugate Drug repurpose methotrexate siderophore
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagyArticle Published on 2022-09-032022-10-06 Journal: Nature Communications [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome addition antiviral therapy autophagic autophagy conjugate conjugation coronavirus deficiency Degradation effective elevated entry receptor enzyme Evidence identify lysine PIAS4 PROTECT receptor SARS-CoV-2 SARS-COV-2 infection selective SENP3 subsequent SUMO3 suppression the SARS-CoV-2 TOLLIP [DOI] 10.1038/s41467-022-32957-y [Article Type] Article
Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion피커링 에멀젼에 의한 에피토프 제시의 2-모드 향상 메커니즘을 사용한 활성 백신 제형을 위한 플랫폼Article Published on 2022-08-152022-09-12 Journal: ACS applied bio materials [Category] SARS, 진단, [키워드] Administered ambient antigenic Antisera applied approach Concentration conditions conjugate correlated determinants Efficacy Efficiency Emulsion enhancement epitope epitope-based vaccination Formulation heterogeneity IgG IgG titer Immunoglobulin include magnitude Pathogens peptide Pickering emulsion plant virus platform presentation subsequent subunit subunit vaccines vaccination Vaccine development Virus-like-particles. vivo assay VLPs [DOI] 10.1021/acsabm.2c00410 PMC 바로가기 [Article Type] Article
A method for Boolean analysis of protein interactions at a molecular level Research Published on 2022-08-132022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 진단, [키워드] Activation amplification Analysis assays Cell complex conjugate detect Determining diagnostic disease Effects fixed generate Health indicate Interaction molecular Mutation Protein protein A protein interaction Protein–protein interaction proximal Research Signaling subcellular tissue [DOI] 10.1038/s41467-022-32395-w [Article Type] Research