Luciola mingrelica firefly luciferase as a marker in bioluminescent immunoassaysReview Published on 2023-08-182024-09-05 Journal: Biophysical Reviews [Category] update2024, [키워드] bioluminescence conjugation Cross-linker firefly luciferase FRET immunoassay Pathogens Pluronic Salmonella [DOI] 10.1007/s12551-023-01115-z PMC 바로가기 [Article Type] Review
Lambda Red Recombineering in Shigella flexneriarticle Published on 2022-12-312024-09-01 Journal: Methods in molecular biology (Clifton, N.J.) [Category] 세균성이질, [키워드] Congo red conjugation Shigella Vaccine development λ-Red recombination [Article Type] article
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagyArticle Published on 2022-09-032022-10-06 Journal: Nature Communications [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome addition antiviral therapy autophagic autophagy conjugate conjugation coronavirus deficiency Degradation effective elevated entry receptor enzyme Evidence identify lysine PIAS4 PROTECT receptor SARS-CoV-2 SARS-COV-2 infection selective SENP3 subsequent SUMO3 suppression the SARS-CoV-2 TOLLIP [DOI] 10.1038/s41467-022-32957-y [Article Type] Article
Conjugation with 8-arm PEG and CRM 197 enhances the immunogenicity of SARS-CoV-2 ORF8 protein8-arm PEG 및 CRM 197과의 접합은 SARS-CoV-2 ORF8 단백질의 면역원성을 향상시킵니다Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] activate adjuvant adjuvants aluminum antigens BALB/c mice carrier protein cellular conjugate Conjugates conjugation COVID-19 pandemic CRM(197) cytokine Cytokines effective effective vaccine Effective vaccines Effectiveness eight-arm PEG. ENhance evaluated expected functions humoral immune response IFN-β IFN-γ IgG IL-5 immune protection immune response immune responses immunogenicity IMPROVE inherent inhibit liver multiple antigen ORF8 ORF8 protein proliferation promoter Protein raise renal SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine SARS-CoV-2 variants splenocyte T helper cell T helper cells the SARS-CoV-2 TNF-α Toxicity Vaccine Vaccines variant [DOI] 10.1016/j.intimp.2022.108922 PMC 바로가기 [Article Type] Article
Immunoassay platform with surface-enhanced resonance Raman scattering for detecting trace levels of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 미량 수준을 검출하기 위한 표면 강화 공명 라만 산란 기능이 있는 면역 분석 플랫폼Article Published on 2022-07-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation antibody coated with comparable Concentration conjugation Conjugation in gold nanoparticles coronavirus disease COVID-19 COVID-19 patient COVID-19 patients disease early diagnosis genetic material gold Gold nanoparticle immunoassay lack limit of detection lowest Methylene Methylene blue multidimensional onset of symptoms plasma platform prevented Protein Resonant Raman molecules SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike protein detection scattering SERRS immunoassay Platform silica Silica shell functionalization. Spike protein Support the immunoassay Viral proteins [DOI] 10.1016/j.talanta.2022.123381 PMC 바로가기 [Article Type] Article
Association of GSTM1 and GSTT1 gene polymorphisms with COVID-19 susceptibility and its outcomeGSTM1 및 GSTT1 유전자 다형성과 COVID-19 감수성의 연관성 및 그 결과Article Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus all subjects antioxidant association Asymptomatic caused Cell Chain Reaction Combination conditions conjugation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 susceptibility cytokine cytokine production death Defense defense mechanism develop enzyme followed by Frequency Genotype genotyped glutathione GSH GST GSTM1 GSTT1 Health illness illnesses Infection Inflammation investigated Lungs mechanism Mild mild patient mild patients Mortality mPCR. multiplex observé outcome oxidative damage oxidative stress pathophysiological Patient polymerase chain polymerase chain reaction polymorphism PROTECT respiratory respiratory diseases RT-PCR SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients significantly statistical analysis subject suggested survival rate susceptibility the cell Trigger triggers with COVID-19 [DOI] 10.1002/jmv.27076 PMC 바로가기 [Article Type] Article
Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering장내 Bacteroidales의 이동형 VI 분비 시스템 유전자좌는 광범위한 생태계 내 이동, 다종 확산 및 지리적 클러스터링을 나타냅니다.Research Article Published on 2021-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Analysis Bacterial Bacteroidale Bacteroidales benefit Clustering Community competitive advantage comprehensive analysis conjugation demonstrated dissemination distribution ecological Ecology element Evolution evolutionary dynamics exclusion expected fitness fixation Genes Genetic genetic architecture Genome genomes genomic globe Gut gut microbiota human population human populations identify Impact loci metagenomic metagenomic analyses microbial microbial ecosystem Microbiome Mobile multi neighboring cell neighboring cells observation phenotype Phenotypes Prevalence Recombination secretion species Spread strain Subtypes These data toxin toxins transfer transferred tRNA Type [DOI] 10.1371/journal.pgen.1009541 PMC 바로가기 [Article Type] Research Article
Genotypic and Phenotypic Characterization of Incompatibility Group FIB Positive Salmonella enterica Serovar Typhimurium Isolates from Food Animal SourcesArticle Published on 2020-11-042023-05-31 Journal: Genes [Category] Fulltext, 조류인플루엔자, [키워드] S. Typhimurium Caco-2 intestinal epithelial cells conjugation IncFIB plasmids persistence SNP tree [DOI] 10.3390/genes11111307 PMC 바로가기 [Article Type] Article
Conjugation of Human β-Defensin 2 to Spike Protein Receptor-Binding Domain Induces Antigen-Specific Protective Immunity against Middle East Respiratory Syndrome Coronavirus Infection in Human Dipeptidyl Peptidase 4 Transgenic MiceArticle Published on 2020-11-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Activation acute respiratory symptoms Adaptive immune response addition adjuvant administration antibody Antigen can be used candidate vaccine cause conjugation defensin Dipeptidyl peptidase 4 domain dose effective Endoplasmic reticulum ENhance enhancing the immunogenicity HBD Human human β-defensin 2 immune response immunization intramuscular intranasal investigated lack lung Medical countermeasures MERS-CoV MERS-CoV infection mice Middle East mucosal IgA response peptidase provided pulmonary fibrosis required respiratory respiratory syndrome coronavirus S RBD Safe Signaling spike Spike protein Stress subunit suppressed vaccination Vaccine vaccine candidate viral infection [DOI] 10.3390/vaccines8040635 PMC 바로가기 [Article Type] Article
Tracing Back the Evolutionary Route of Enteroinvasive Escherichia coli (EIEC) and Shigella Through the Example of the Highly Pathogenic O96:H19 EIEC Clone장내침습성 대장균(EIEC)과 시겔라의 진화 경로를 고병원성 O96:H19 EIEC 클론의 예를 통해 추적하기Original Research Published on 2020-06-032024-07-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] 세균성이질, [키워드] conjugation EIEC emerging clones Evolution Phylogenomics [DOI] 10.3389/fcimb.2020.00260 PMC 바로가기 [Article Type] Original Research