A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study)Article Published on 2022-09-272022-11-15 Journal: BMC Medicine [Category] SARS, 진단, [키워드] 95% confidence interval Administered age airway Analysis asymptomatic patients Bayesian camostat camostat mesilate cardiovascular diseases cells Chronic kidney disease chronic respiratory disease clinical conducted consecutive negative test conversion COVID-19 COVID-19 symptom Diabetes Mellitus dose double-blind Drug screening effective Efficacy and safety eight enrolled evaluate Factor first test hospital human airway epithelial hypertension indicated Japan median time Mild moderate multicenter no significant difference obesity parallel-group Patient patients patients with COVID-19 Placebo placebo-controlled study Positive test Prevent primary efficacy endpoint Randomized Randomized controlled trial receive reduce registry SARS-CoV-2 SARS-COV-2 infection the placebo group the primary endpoint Treatment two groups underlying disease viral clearance viral loads was performed were blinded were excluded without symptoms [DOI] 10.1186/s12916-022-02518-7 PMC 바로가기
Traditional Chinese medicine treatment for COVID-19: An overview of systematic reviews and meta-analysesCovid-19에 대한 전통 중국 의약 치료 : 체계적인 검토 및 메타 분석의 개요Review Published on 2022-09-012022-08-31 Journal: Journal of integrative medicine [Category] meta-analysis, 임상, 치료법, [키워드] addition Analysis assessment can be used caused China Chinese Chinese traditional Chongqing clinical decision Clinical efficacy clinical outcomes clinical trial clinical trials Cochrane Library Combination control group conversion coronavirus disease Coronavirus disease 2019 COVID-19 data extraction Decision making defined development duration of symptoms Efficacy evaluate evaluated Evidence evidence of examined Factors Hospital stay improve clinical outcomes indicated Infrastructure integrative medicine intervention group lung measurement Medicine meta-analyses Meta-analysis Methodological quality moderate Mortality outcome outcome measure performed proliferation Randomized controlled trial Randomized controlled trials rapidly spreading disease review searched SinoMed Symptom systematic review systematic reviews TCM therapy Traditional Chinese medicine Treatment Version VIP was used Web of Science were used [DOI] 10.1016/j.joim.2022.06.006 PMC 바로가기 [Article Type] Review
RT- PCR testing of upper respiratory tract samples for diagnosis of SARS-CoV-2: Between justification and overestimation, a multi-center international studySARS-CoV-2 진단을 위한 상기도 샘플의 RT-PCR 검사: 정당화와 과대평가 사이, 다기관 국제 연구Multicenter Study Published on 2022-07-012022-09-11 Journal: Travel medicine and infectious disease [Category] COVID19(2023년), SARS, 치료기술, [키워드] affected Analysis bilateralism Binary logistic regression binary logistic regression analysis chain Chain Reaction chronic obstructive chronic obstructive pulmonary disease clinical care collected conversion Conversion time COVID COVID 19 COVID 19 patient COVID-19 Critical detectable determine Diagnosis effective elevated erythrocyte sedimentation erythrocyte sedimentation rate Factor Factors false false-negative false-negative results Fever headache Health Hospitalized hospitalized patient hypertension identifying incidence independent risk factor independent risk factors infectious initial interfere International Isolation likelihood lobe lobes lymphopenia median negative RT-PCR obstructive pulmonary disease Occurrence outcome Patient patients polymerase chain reaction positive positive RT-PCR pulmonary disease radiological reaction RT- PCR RT-PCR SARS-CoV-2 RNA sedimentation rate tested upper respiratory tract [DOI] 10.1016/j.tmaid.2022.102334 PMC 바로가기 [Article Type] Multicenter Study
Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation안지오텐신 전환 효소 2(ACE2): 20년 간의 폭로와 재평가Review Published on 2022-05-012022-09-11 Journal: Peptides [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE2 acting Amino acid amyloid angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme-2 binding cardiovascular caused cell membrane cell type conversion coronavirus counterbalance COVID COVID-19 pandemic driving ectoenzyme enzyme event expressed Factor homology implicated Inflammatory mechanisms membrane protein neprilysin pathological conditions Pathologies pathology Pathways peptide peptides physiological producing Protective provide provided receptor regulate Renin renin-angiotensin system sACE2 SARS SARS virus SARS-CoV2 specificity susceptibility therapeutic target Transport Treatment Vascular Vasoactive Vasopeptidase. virus Zinc [DOI] 10.1016/j.peptides.2022.170766 PMC 바로가기 [Article Type] Review
The interacting physiology of COVID-19 and the renin-angiotensin-aldosterone system: Key agents for treatmentCOVID-19와 레닌-안지오텐신-알도스테론 시스템의 상호작용 생리: 치료의 핵심 인자Review Published on 2022-02-012022-09-11 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 Activation aldosterone alteration Ang II angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 Arm circulating circulation circulatory system contrary conversion COVID-19 destruction dysregulated Effect Effects enzyme fluids homeostasis Host host response Infection Inflammation Inflammatory response Injury limit maintain metabolism Pathogenesis pathogenesis of COVID-19 peptide pro-inflammatory action pro-inflammatory actions RAAS receptor regulated Renin renin-angiotensin system renin-angiotensin-aldosterone system respond responsible SARS-CoV-2 steroid steroid hormone Therapies tissue tissue perfusion trauma Treatment turn viral infection Volume [DOI] 10.1002/prp2.917 PMC 바로가기 [Article Type] Review
Negative Nasopharyngeal SARS-CoV-2 PCR Conversion in Response to Different Therapeutic InterventionsInfectious Disease Published on 2022-01-202022-10-31 Journal: Cureus [Category] COVID-19, [키워드] accelerate antimalarial antiviral drug association Care Chloroquine clearance Combination conversion Course COVID-19 diagnosis of COVID-19 FIVE HCQ hospital Hydroxychloroquine Infection prevention Infectious disease interquartile range Intervention management median time medication nasopharyngeal negative Negative PCR Novel coronavirus Patient PCR polymerase chain prescribing response Result retrospective cohort study SARS-CoV-2 SARS-CoV-2 PCR Saudi Arabia secondary endpoint shown statistically significant difference supportive care the disease the median therapeutic interventions [DOI] 10.7759/cureus.21442 PMC 바로가기 [Article Type] Infectious Disease
Two Doses of BNT162b2 mRNA Vaccine in Patients after Hematopoietic Stem Cell Transplantation: Humoral Response and Serological Conversion PredictorsArticle Published on 2022-01-102022-10-31 Journal: Cancers [Category] COVID-19, [키워드] addition adverse event adverse events Allogeneic allogeneic transplantation Analysis anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody autologous B-cell BNT162b2 mRNA vaccine CNI collected Concentration conversion correlated COVID-19 COVID-19 pandemic dose Efficacy Efficacy and safety examined HCT Hematological malignancies hematopoietic hematopoietic stem cell transplantation humoral Humoral response immune response predictors immunogenic Immunosuppressive treatment inhibitor intensity knowledge lack lymphocyte subpopulation mRNA mRNA vaccine multivariate model of BNT162b2 Patient patients Post-vaccine predictor predictors remained response SARS-CoV-2 SARS-COV-2 infection searched Seroconversion serological simple STEM Stem cell transplantation Treatment Univariate analysis vaccination [DOI] 10.3390/cancers14020325 PMC 바로가기 [Article Type] Article
Reinforcing the supply chain of umifenovir and other antiviral drugs with retrosynthetic software역합성 소프트웨어로 우미페노비르 및 기타 항바이러스제 공급망 강화Article Published on 2021-12-162022-09-10 Journal: Nature Communications [Category] SARS, 신약개발, 치료제, [키워드] Anti-inflammatory drugs Antiviral antiviral drug bromhexine can be used caused Chemical synthesis Cheminformatics conversion coronavirus COVID-19 develop fragility functional functional groups goods groups identify methodology Multiple pandemic pathway raw materials Reinforcing required Stress Supply chain supply chains target therapeutic umifenovir unlikely [DOI] 10.1038/s41467-021-27547-3 PMC 바로가기 [Article Type] Article
Myoglobin and troponin as prognostic factors in patients with COVID-19 pneumoniaCOVID-19 폐렴 환자의 예후 인자로서의 미오글로빈 및 트로포닌Article Published on 2021-08-272022-09-11 Journal: Medicina clínica [Category] MERS, SARS, 바이오마커, [키워드] 95% CI analyses Analysis analyzed caused characteristic Characteristics clinical Clinical characteristics collected conversion coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 COVID-19 patient COVID-19 patients Cox model Critical Critical illness death death group death in COVID-19 demonstrated died disease elevated eligible Enfermedad por coronavirus 2019 English enrolled Final hospitalized patient independent indicate IQR Kaplan-Meier Kaplan-Meier survival analysis laboratory data marker Mioglobina Mortality multifactorial muscular myocardial injury Myoglobin Novel coronavirus novel coronavirus pneumonia outbreak Patient patient death patients with COVID-19 Pneumonia predict Predictive Predictive value predictor Probability Prognosis prognosis of patients prognostic Prognostic factor Pronóstico receiver operating characteristic receptor reported ROC ROC Curve ROC curves Serum level serum levels significantly significantly lower Sin Spanish suggested survival survival analysis survival curve Survival curves survived the patient threshold troponin Troponina with COVID-19 Wuhan Wuhan, China [DOI] 10.1016/j.medcli.2021.01.013 PMC 바로가기 [Article Type] Article
Add-on effect of Chinese herbal medicine in the treatment of mild to moderate COVID-19: A systematic review and meta-analysis경증에서 중간 정도의 Covid-19의 치료에서 중국 약초의 추가 효과 : 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-08-202022-09-10 Journal: PLoS ONE [Category] MERS, 치료제, [키워드] 1.26 95% CI 95%CI Bia Biology CBM China Chinese CHM clinical CNKI combating combination therapy Controlled controlled trials conversion coronavirus disease Coronavirus disease 2019 cough COVID-19 COVID-19 cases COVID-19 pandemic cure rate database effective eligible Epidemic epidemiological Epidemiological investigations evaluate exclusion criteria Fever global pandemic help herbal medicine Inclusion inclusion and exclusion criteria Infrastructure journal Lung CT Medicine Meta-analysis Methodological quality Mild mild to moderate Mild to moderate COVID-19 moderate Moderate COVID-19 outbreak parameter participant Prevent progression proportion RCT RCTs Result review robust Safe Science searched selected sensitivity analysis Severe case severe cases shown significantly higher significantly lower statistical analysis Symptom systematic review TCM technology therapy treat Treatment Trial VIP was used WBC WBC count website Wuhan Wuhan, China [DOI] 10.1371/journal.pone.0256429 PMC 바로가기 [Article Type] Meta-Analysis