Safety, pharmacokinetics and antiviral activity of ABI-H2158, a hepatitis B virus core inhibitor: A randomized, placebo-controlled phase 1 studyClinical Trial Published on 2023-03-012023-06-12 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Antiviral core inhibitor Hepatitis B virus pharmacokinetics phase 1 study. [DOI] 10.1111/jvh.13764 [Article Type] Clinical Trial
Preclinical characterization of ABI-H2158, an HBV core inhibitor with dual mechanisms of actionArticle Published on 2023-01-012023-06-13 Journal: Antiviral Research [Category] B형 간염, [키워드] cccDNA core inhibitor HBV pgRNA encapsidation. [DOI] 10.1016/j.antiviral.2022.105485
EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis BArticle Published on 2022-12-012023-06-13 Journal: Antiviral therapy [Category] B형 간염, [키워드] capsid assembly modulator Chronic Hepatitis B core inhibitor core protein allosteric modulator Hepatitis B virus Pharmacodynamics pharmacokinetics Safety [DOI] 10.1177/13596535221127848
Safety and efficacy of vebicorvir administered with entecavir in treatment-naïve patients with chronic hepatitis B virus infectionClinical Trial Published on 2022-11-012023-06-13 Journal: Journal of hepatology [Category] B형 간염, [키워드] ABI-H0731 Chronic hepatitis B virus core inhibitor entecavir nucleos(t)ide reverse transcriptase inhibitor Phase 2 treatment-naive Vebicorvir [DOI] 10.1016/j.jhep.2022.05.027 [Article Type] Clinical Trial
Safety and efficacy of vebicorvir in virologically suppressed patients with chronic hepatitis B virus infectionClinical Trial Published on 2022-09-012023-06-12 Journal: Journal of hepatology [Category] B형 간염, [키워드] Antiviral cccDNA core inhibitor HBV Hepatitis NRTI pgRNA [DOI] 10.1016/j.jhep.2022.04.005 [Article Type] Clinical Trial
Moving Fast Toward Hepatitis B Virus EliminationArticle Published on 2021-01-012023-06-12 Journal: Advances in experimental medicine and biology [Category] B형 간염, [키워드] cccDNA core inhibitor DAA—directly acting antiviral hepatitis B Hepatocellular carcinoma immune therapy [DOI] 10.1007/978-981-16-0267-2_5 PMC 바로가기
Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731Article Published on 2020-08-312023-05-23 Journal: Antimicrobial Agents and Chemotherapy [Category] B형 간염, Fulltext, [키워드] Antiviral agents capsid cccDNA core inhibitor core protein Cp Hepatitis B virus pgRNA packaging pregenomic RNA [DOI] 10.1128/AAC.01463-20 PMC 바로가기
Future anti-HBV strategiesReview Published on 2017-01-012023-06-18 Journal: Liver international : official journal of the Inte [Category] B형 간염, [키워드] cccDNA silencing core inhibitor HBV cure immunomodulator siRNA [DOI] 10.1111/liv.13304 [Article Type] Review