coronavirus pathogenesis – Communicable Diseases Research

Insight towards the effect of the multi basic cleavage site of SARS-CoV-2 spike protein on cellular proteases

Article

Published on 2022-06-062022-11-01
Journal: Virus research [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] acute respiratory syndrome Amino acid amino acid substitution Analysis analyzed Antiviral approach binding cathepsin B cell receptor cellular cellular protease cellular proteases cleavage site cleaving coronavirus coronavirus pathogenesis develop domain functional furin furin cleavage site generate Health help Host host cell protease host protease host range incorporation indicated Infection inhibitor insight Interaction involved maturation MD simulation MD simulations molecular molecular docking multi Mutation plasmin polybasic primary determinant protease Protein proteolytic activation Receptor binding S protein S1 and S2 SARS-CoV-2 SARS-CoV-2 spike protein shown spike Spike protein Spread subunits the S protein tissue tropism
[DOI] 10.1016/j.virusres.2022.198845 PMC 바로가기 [Article Type] Article

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

Research Article

Published on 2021-08-042022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies

COVID-19 병리학에서 팔미트산 증대의 분자 메커니즘

Article

Published on 2021-07-012022-09-12
Journal: International Journal of Molecular Sciences [Category] SARS, 진단,

[키워드] ACE2 Activation Affect affected apoptotic attenuate augmentation base Biological biological molecules canonical CCL2 CCL5 Cell cell surface receptor chemokines claimed coronavirus disease Coronavirus disease 2019 coronavirus pathogenesis COVID-19 COVID-19 pathology Cytokines dataset EEF1A1 elevated exacerbate expression Fatty acid fatty acids FFA FFAs free fatty acid free fatty acids IL1β Inflammatory mediators Ingenuity Pathway Analysis inhibiting knowledge base modulate molecular mechanism molecular mechanisms Mortality n-3 fatty acid NFκB obese obesity palmitic acid pandemic Pathologies pathway progression PTGS2 retrieved SARS-CoV-2 spike protein severity Spike protein subjects surface receptor the SARS-CoV-2 transcription factors translation were used
[DOI] 10.3390/ijms22137127 PMC 바로가기 [Article Type] Article

Development of immunohistochemistry and in situ hybridisation for the detection of SARS-CoV and SARS-CoV-2 in formalin-fixed paraffin-embedded specimens

포르말린 고정 파라핀 포매 표본에서 SARS-CoV 및 SARS-CoV-2 검출을 위한 면역조직화학 및 in situ hybridization 개발

Article

Published on 2020-12-142022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] addition against SARS-CoV animal animal models antibody Antigen antigen retrieval method applied causative agent caused coronavirus coronavirus pathogenesis COVID-19 demonstrated detect determine development dissemination evaluated expressing facilitate FFPE flexibility formalin formalin-fixed paraffin-embedded IHC immunohistochemistry infected cell infected cells Live virus MERS Microscopy non-infected cell non-infected cells nucleoprotein paraffin positive control probe protocol public health Research RNA SARS-CoV SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 viral specimen spike gene Spike protein tested therapeutic Therapeutics tissues utility Vaccine Viral virus virus detection
[DOI] 10.1038/s41598-020-78949-0 PMC 바로가기 [Article Type] Article

Camelid Inoculation with Middle East Respiratory Syndrome Coronavirus: Experimental Models of Reservoir Host Infection

Review

Published on 2020-11-302022-10-28
Journal: Viruses [Category] COVID-19, Fulltext,

Management of epigenomic networks entailed in coronavirus infections and COVID-19

Review

Published on 2020-08-052022-10-31
Journal: Clinical Epigenetics [Category] COVID-19, MERS,

[키워드] acute respiratory syndrome Antiviral approach approved clinical trials clinically combination therapy coronavirus Coronavirus disease 2019 Coronavirus infection Coronavirus infections coronavirus pathogenesis COVID-19 COVID-19 disease CoVs death deaths drug effective emerging disease Epigenetic epigenomic Focusing Gene Expression genomic immune system increase in indicated infected case Inflammation Inflammatory marker MERS-CoV Middle East molecular mechanism Mutation outcome pathogen Patient Recombination Regulation Replication respiratory syndrome coronavirus respiratory tract SARS-CoV SARS-CoV-2 single-stranded RNA virus susceptibility the cytokine storm therapy Transcription viral entry viral replication virus Virus-host interaction worldwide pandemic
[DOI] 10.1186/s13148-020-00912-7 PMC 바로가기 [Article Type] Review

A Review: Does Complement or the Contact System Have a Role in Protection or Pathogenesis of COVID-19?

Review

Published on 2020-05-132022-10-28
Journal: Pulmonary Therapy [Category] COVID-19,

[키워드] ACE2 acute respiratory distress Angiotensin receptors antagonists anti-IL-6 antiviral therapy approval ARDS benefit bradykinin complement Contact contact system convalescent plasma coronavirus coronavirus pathogenesis Corticosteroids COVID-19 cytokine Cytokine storm death defined edema effective enzyme etiology Evidence Human Hydroxychloroquine include increase in Intervention investigated knockout mice less Lung disease manuscript mice mouse model office Pathogenesis Pneumonia Potential treatment protection Protective Pulmonary edema receptor Result risk role SARS-CoV SARS-CoV-2 searched syndrome System the disease therapeutic intervention Treatment viruses wild-type
[DOI] 10.1007/s41030-020-00118-5 PMC 바로가기 [Article Type] Review

SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium

Article

Published on 2007-04-232022-11-01
Journal: Virus research [Category] Coronavirus, MERS,

[키워드] addition airway airway epithelial cells airway epithelium Antisera apical surface Atypical Calu-3 Calu-3 cell Cell cells cellular Characteristics ciliated ciliated cell consequence coronavirus coronavirus pathogenesis Coronavirus replication Culture cultures detected develop did not reduce dry cough efficient enzyme Epidemics epithelial epithelial cell epithelial cell line Experimental result feature Fever fluorescent Frame GFP hACE2 HAE Human human airway epithelia human airway epithelial Human airway epithelium human lung human pathogen in vitro in vitro model in vivo Infection inoculated insertion late stage log Lower respiratory tract lung lung epithelial mechanism Morphological new strain onset of symptoms ORF Pathogenesis pathology physiological Pneumonia Post-infection primary cell progeny virion Protein provide reached receptor reduced replicate replicated Replication reported reservoir respiratory virus resulting SARS Coronavirus SARS-CoV SARS-CoV GFP SARS-CoV infection Support susceptible target tight junction Trachea Vero E6 viral infection viral replication viral titer virus wild type zoonotic
[DOI] 10.1016/j.virusres.2007.03.013 PMC 바로가기 [Article Type] Article

SARS coronavirus and innate immunity

Article

Published on 2007-04-232022-11-01
Journal: Virus research [Category] Coronavirus, Fulltext, MERS, SARS,