The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cellsArticle Published on 2022-11-022022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 진단, [키워드] Affect analyses autophagy Better boost cancer cell cancer cell lines Cell cell type ciliated conducted COVID-19 pathology COVID19 Critical eight endocytosed enterocytes experiment expressed Factor Genetic genetic screen Gut help Host host cell human cell human lung identify impair Infection Interaction lentiviruses loss-of-function lysosomal lysosomal membrane overexpression plac8 plasma Protein regulate respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses secretory cell single-cell SPNS1 spns1. susceptible viral entry viral infection virions [DOI] 10.15252/embj.2022110727 PMC 바로가기
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responsesArticle Published on 2022-10-242022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 activated Activation alleviate Antigen CD169 CD169+ macrophage contribute COVID-19 pathology COVID-19 patients de novo elicited exogenous ACE2 expression expression of SARS-CoV-2 facilitated genomic humans Hyperinflammatory IL-1β IL-6 independent induce Infection innate immune response Macrophage macrophages MDA-5 monocyte myeloid cell Post-mortem primary target cell pro-inflammatory cytokine pro-inflammatory response Remdesivir Replication Restricted RIG-I RNA SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection subgenomic RNA subsequent suppressed the SARS-CoV-2 thought TNFα Treatment viral particle Viral protein Viral RNA [DOI] 10.1371/journal.ppat.1010479 PMC 바로가기
COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and MicrothrombosisArticle Published on 2022-10-042022-11-15 Journal: Cells [Category] COVID19(2023년), SARS, 진단, [키워드] activated activated macrophages Activation age antibody Autopsy B-lymphocytes Brain change characteristic Clinical course controls COVID-19 COVID-19 case COVID-19 pathology elderly exhibited feature foci greater heart hearts highest Hyperactivation Inflammation Inflammatory kidney kidneys lung lung; Lymphocytes microglial Microthrombosis Neuropathology nine other tissue pathology pathophysiology PCR Platelets predominant role SARS-CoV-2 significantly significantly higher T-lymphocyte T-lymphocytes the disease tissue tissues viral antigens viral replication Viral RNA were used [DOI] 10.3390/cells11193124 PMC 바로가기
Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning methodResearch article Published on 2022-10-012022-10-05 Journal: Applied Soft Computing [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis approach artificial intelligence assist available data Bioinformatics analysis biological pathway Biomarkers Comprehensive comprehensive analysis coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathology defined disease dominant effective Features first stage help host cell implementation introduced machine learning material Novel coronavirus pathway Pathway analysis Pathway enrichment analysis Pathways researcher SARS-CoV-2 selected Signaling target Treatment unsupervised learning WHO World Health Organization worldwide crisis [DOI] 10.1016/j.asoc.2022.109510 [Article Type] Research article
Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosisArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] accompanied acute respiratory distress addition Comorbidity coronavirus disease COVID-19 COVID-19 pathology cytokine production decrease dysregulated immune response effective Efficacy Evidence functions glycyrrhiza Glycyrrhiza glabra Hamster model hamsters hypercoagulable IL-17A IL-4 immunocompromised individuals immunomodulator immunomodulatory properties Inflammatory cytokine ingredient Lung pathology lung viral load mice mice and human neutrophil functions. mitigate Mortality mRNA expression murine NET NETosis neutrophil polymorphonuclear neutrophil pro-inflammatory cytokine Protective provide Pulmonary pathology reduced reducing robust ROS SARS-CoV-2 SARS-COV-2 infection skewed suppress syndrome Th17 Th2 Th2/Th17 differentiation Treatment vaccination Vaccine variant [DOI] 10.3389/fimmu.2022.945583 PMC 바로가기
COVID-19 and the Immune Response: A Multi-Phasic Approach to the Treatment of COVID-19COVID-19와 면역 반응: COVID-19 치료에 대한 다단계 접근Review Published on 2022-08-032022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive approach cause Characteristics Complication Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathology cytokine Cytokine storm disease exacerbated flu-like symptom flu-like symptoms Hyperactivation identify IL-6 immune immune mechanism immune response Immunosuppressant immunosuppressants Immunotherapy Infection initial involved Killer cell life-threatening monoclonal monoclonal antibodies monoclonal antibody multi-phasic multiphasic natural killer natural killer cell Replication SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Stage symptom duration Symptoms systematic review Treatment treatment approach viral replication [DOI] 10.3390/ijms23158606 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusionADAM10 및 ADAM17은 SARS-CoV-2 세포 진입 및 스파이크 단백질 매개 폐 세포 융합을 촉진합니다Article Published on 2022-06-072022-09-11 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A549 ADAM10 ADAM17 Alpha antiviral drug apratastat Beta causative agent Cell Cell fusion cleave contribute contributing to COVID-19 COVID-19 pathogenesis COVID-19 pathology DPC-333 ectodomain ectodomain shedding expressed facilitator hallmark Host host cell host cell factor host cell factors human lung human lung cell identify impair in vitro Infection inhibitor lung cell omicron Pathogenesis pathology priming promote protease Proteases reduce required SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variants Spike protein syncytia formation syncytia formation. target the SARS-CoV-2 TMPRSS2 TMPRSS2 protease variants of concern viral entry [DOI] 10.15252/embr.202154305 PMC 바로가기 [Article Type] Article
Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathologyCOVID-19 관련 세포 면역 병리학에서 sMAdCAM 및 IL-15의 반대 역할Article Published on 2022-06-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Activation Adhesion Molecule association Asymptomatic Asymptomatic cases CD4+ CD8 Cell cell adhesion molecule cellular characterized circulating Cohort correlated COVID COVID-19 COVID-19 pathology cytokine disease Disease progression duration of hospitalization dysfunction dysregulation effector memory ELISA evaluated Factors flow cytometry Frequency healthy control healthy controls homeostasis homeostatic hypoxemic IL-15 IL-6 IL-6 level IL-6 levels immune increase in India infected individuals Inflammatory factor inflammatory factors intermediate monocytes involved lymphocyte lymphopenia marker Mild moderate moderate to severe monocyte Monocytes mucosal multiparametric flow cytometry Mumbai Pathogenesis pathology plasma profiles quantified recruited regulatory T cells SARS-CoV-2 SARS-CoV-2 infected individual SARS-CoV-2 infected individuals severe disease sMAdCAM. Stage subset symptomatic individual symptomatic individuals symptomatic infection T cells was used while [DOI] 10.1002/JLB.3COVBCR0621-300R PMC 바로가기 [Article Type] Article