COVID-19 clinical trial participation and awareness in TexasCoronavirus Published on 2024-04-242024-09-05 Journal: Human vaccines & immunotherapeutics [Category] update2024, [키워드] clinical trials COVID-19 COVID-19 treatments health communication public health Vaccines [DOI] 10.1080/21645515.2024.2340692 PMC 바로가기 [Article Type] Coronavirus
COVID-19 treatments approved in the European Union and clinical recommendations for the management of non-hospitalized and hospitalized patientsArticle Published on 2022-12-012022-11-15 Journal: Annals of Medicine [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] addition affecting alleviate antiviral medication antiviral medicine approved Baricitinib Care caused Clinical practice clinical recommendations Community courses COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 treatment COVID-19 treatments Critical deaths develop disease disorder drug Dyspnea effective effective drugs European European Medicines Agency European Union Evidence guidelines Health healthcare hospital Hospitalization Hospitalized hospitalized patient hypoxia Intervention involved life-threatening lung involvement management Mild moderate molnupiravir monoclonal antibodies monoclonal antibody Most patient Multiorgan dysfunction New outcome public health recommendation Remdesivir Respiratory failure rheumatoid arthritis SARS-CoV-2 Septic shock severe symptom Symptom the disease the patient therapy Thromboembolism Tocilizumab treat Treatment treatment strategy union vaccination [DOI] 10.1080/07853890.2022.2133162 PMC 바로가기
What are the long-term holistic health consequences of COVID-19 among survivors? An umbrella systematic reviewArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute COVID-19 acute phase acute respiratory syndrome affected conducted consequence coronavirus COVID-19 COVID-19 treatments demographic data determine eligibility criteria employment Epidemiology fatigue functional Health Impact individual Laboratory parameters memory Pandemics Participants physical Psychological psychological impacts Quality of life ranged Research respiratory symptoms Sample SARS Coronavirus screened survived Survivors systematic review systematic reviews variant virus virus classification [DOI] 10.1002/jmv.28086 PMC 바로가기
Racial and Ethnic Disparities in Outpatient Treatment of COVID-19 – United States, January-July 2022Article Published on 2022-10-282022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] 치료제, [키워드] African American Alaska Antiviral Antiviral treatment antivirals Asian black booster doses Care COVID-19 COVID-19 in patient COVID-19 patient COVID-19 treatments COVID-19 vaccination disparity drug EHR Emergency use authorization EUA facilitate food Health help high risk highest Hispanic patient Immunocompromised less mAb medication Mild-to-moderate molnupiravir monoclonal antibody Native outcomes Outpatient Patient patient groups patients Paxlovid PROTECT Racial Remdesivir report risk seeking severe COVID-19 treated Treatment United States were used White patients [DOI] 10.15585/mmwr.mm7143a2 PMC 바로가기
The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological EvaluationArticle Published on 2022-10-092022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Allosteric inhibitor aryl nitrile assessments binding Biological candidate carried Characteristics Compound COVID-19 COVID-19 treatments docking enzyme inhibitor Ligand M pro mechanism medium MPro protease SARS-CoV-2 Screening selected Site Structure-based virtual screening suggested target the SARS-CoV-2 Treatment Virtual screening [DOI] 10.3390/molecules27196710 PMC 바로가기
How do frontline healthcare workers learn from COVID-19 webinars during a pandemic? An online survey studyArticle Published on 2022-10-012023-07-10 Journal: Hospital practice (1995) [Category] COVID19(2023년), [키워드] COVID-19 COVID-19 treatments COVID-19 webinars digital burnout. [DOI] 10.1080/21548331.2022.2114741
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2′-O-ribose methyltransferasesArticle Published on 2022-09-012022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] AHCY Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral drug antivirals attenuation Concomitant COVID-19 COVID-19 treatments Drug screening DZNep enzyme Ex vivo exhibit functional Host host-directed hyperinflammation identify Immune escape immunomodulatory effect in silico in vitro in vivo independent Infection Inflammation inhibitor Interaction Lung fibrosis marker Methylation methyltransferase pathogen reduce SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Side effects Stage suppresse Treatment Viral RNA virus replication [DOI] 10.15252/embj.2022111608 PMC 바로가기
Randomized controlled trials in patients with COVID-19: a systematic review and critical appraisalResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 임상, [키워드] Biase conducted Controlled trial country COVID-19 COVID-19 treatments critical appraisal deviation domain evaluate FIVE high risk independent Intervention LMICs mitigate moderate-severe objective outcome participant Patient performed Placebo Potential Prevalence protocol random randomization randomized trial randomized trials reported Result risk risk of bia Risk of bias risks of bia RoB selective systematic review therapeutic intervention Trial trials [DOI] 10.1016/j.ijid.2022.05.034 [Article Type] Research article
BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor DiscoveryArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cells 3C-like protease 3CLpro Activation activity anti-SARS-CoV-2 activities Antiviral biosensor BRET BSL-2 BSL-2 laboratory BSL-3 C-terminus can be used Cell cellular cleavage clinical trial coronavirus diseases COVID-19 COVID-19 treatments decrease drug target embryonic kidney energy transfer evaluate evaluated fluorescent inhibitor inhibitors level 3 linker N-terminus overexpression polyproteins protease Protein released Renilla luciferase reported reproducibility restored resulting SARS-CoV-2 self-cleavage self-cleaving biosensor. sequence small molecule inhibitor treat virus [DOI] 10.1128/spectrum.02559-21 PMC 바로가기
Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 HelicaseSARS-CoV-2 헬리카제에 대한 약물 및 천연물의 전산 용도 변경으로 인한 잠재적인 COVID-19 치료법Article Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analgesic anticancer Anticoagulant Antihistamine Antihistamines Antiviral agents antivirals antrafenine applied approach aprepitant AutoDock vina binding energy cabotegravir calculate COVID-19 COVID-19 therapy COVID-19 treatments dicoumarol drug Drug repurposing drugs epirubicin Evidence fexofenadine Helicase in silico in vitro in vivo molecular molecular docking molecular dynamics natural non-structural protein nsp13 Potential potential COVID-19 treatments product Protein reported Repurposed drug Repurposed drugs repurposing RSV-604 SARS-CoV-2 Screen tandem the SARS-CoV-2 Treatment Virtual screening [DOI] 10.3390/ijms23147704 PMC 바로가기 [Article Type] Article