Favipiravir Analogues as Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase, Combined Quantum Chemical Modeling, Quantitative Structure–Property Relationship, and Molecular Docking StudyArticle Published on 2024-01-162024-09-05 Journal: Molecules [Category] update2024, [키워드] binding modes COVID-2019 favipiravir analogues hydrogen bonds interaction patterns RNA viruses SARS-CoV-2 [DOI] 10.3390/molecules29020441 PMC 바로가기 [Article Type] Article
Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute MyocarditisArticle Published on 2022-04-122023-07-08 Journal: Circulation [Category] COVID19(2023년), [키워드] cardiac COVID-2019 MRI myocarditis outcome SARS-CoV-2 [DOI] 10.1161/CIRCULATIONAHA.121.056817 PMC 바로가기
A New Perspective of COVID-19 Infection: An Epigenetics Point of ViewReview Article Published on 2022-03-192022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] ACE2 age cellular changed Coronavirus disease 2019 Coronavirus infection COVID-19 COVID-2019 enzyme Epigenetic epigenetic modification epigenetics Genome highlight homoeostasis Host Infection Interaction Methylation Modification New Point protease provided receptor serine 2 susceptibility transmembrane Variation View viral infection viral replication virus virus infection with COVID-19 Wuhan, China [DOI] 10.1055/s-0041-1736565 PMC 바로가기 [Article Type] Review Article
The impact of the Covid-19 pandemic on maternal delivery experiences and breastfeeding practices in China: data from a cross-sectional studyResearch Published on 2022-02-242022-10-28 Journal: BMC Pediatrics [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] 95% confidence interval 95%CI added age Beijing Birth breast-feeding Breastfeeding China clinics Contact country COVID-19 COVID-19 pandemic COVID-2019 cross-sectional Effect eight group Health health system highlight infant feeding Intention Local lockdown maternal age measure moderate mother objective pandemic Postpartum predicted predictor pregnant provided public health reduced reported Result Seven significantly more supplementary material Support thought virus spread was performed women [DOI] 10.1186/s12887-022-03155-y PMC 바로가기 [Article Type] Research
Increased Circulating Cytokines Have a Role in COVID-19 Severity and Death With a More Pronounced Effect in Males: A Systematic Review and Meta-AnalysisPharmacology Published on 2022-02-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome article Asian caused circulating claimed coronavirus Coronavirus disease 2019 COVID-19 COVID-19 severity COVID-2019 cytokine Cytokines Cytokines storm death death group demonstrated driving Effect elevated Epidemic European Evidence Factor females groups high mortality identify IL-10 IL-17 IL-1β IL-4 IL-6 IL-8 Increased increased mortality Inflammatory cytokine interleukin-6 key factor male Meta-analysis Mortality much higher Necrosis non-survivor Patient patients potential risk predisposition receptor review risk of bia role SARS-CoV-2 screened searched Serum level severity Sex Sex bias significantly the mean TNF-α upregulation Web of Science were measured [DOI] 10.3389/fphar.2022.802228 PMC 바로가기 [Article Type] Pharmacology
Novel multi-site graph convolutional network with supervision mechanism for COVID-19 diagnosis from X-ray radiographsResearch article Published on 2022-01-012022-10-05 Journal: Applied Soft Computing [Category] 바이오마커, [키워드] Accuracy addition adopted affected alleviate Biomarker Blood Chest computed tomography chest X-ray radiographs Classifier collected Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-2019 dataset datasets deficiency diagnose Diagnosis Effectiveness experiment Extensive global pandemic healthy include information initial limitation mechanism Multi-site graph convolutional network novel nucleic acid test outlier overcome overfitting performed positive researcher resources Result Supervision mechanism suppress the antibody the disease transfer Transmissibility VGG-16 network virus X-ray [DOI] 10.1016/j.asoc.2021.108041 [Article Type] Research article
Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorderResearch article Published on 2021-12-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘, [키워드] Activation Affect Analysis approach biological processe blood gene expression Case report cause characterized coronavirus disease COVID-19 COVID-19 patient COVID-2019 dataset DEGs detect differentially expressed gene disease disorder downregulated dysregulated Genes Genetic immune induce involved mechanism molecular mechanism molecular pathways mononuclear cell Novel coronavirus Parkinson’s disorder pathway Pathways Patient PBMC Peripheral blood recent regulate RELA SARS-CoV-2 SP1 Symptom TP53 transcriptional regulators transcriptional signatures transcriptomic Treatment upregulated [DOI] 10.1016/j.sjbs.2021.07.074 [Article Type] Research article
School reopening and risks accelerating the COVID-19 pandemic: A systematic review and meta-analysis protocolStudy Protocol Published on 2021-11-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] 95% CI addition Adults Alpha Analysis assessment carried certainty of evidence children clinical CNKI Cochrane Library Consensus country COVID-19 COVID-2019 Critical critical appraisal Data analysis data extraction database development disease transmission estimate evaluate Evidence feasibility feasible Google Scholar Gray help heterogeneity include investigator library literature mental health Meta-analysis objective observational studies pandemic potential risk Pro protocol provided Public quest R statistical software reached retrieved risk risk of bia robust Safe School selected Source systematic review vaccination Web of Science while [DOI] 10.1371/journal.pone.0260189 PMC 바로가기 [Article Type] Study Protocol
Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome at Hospital Admission in Patients with COVID-19Article Published on 2021-11-152022-10-28 Journal: Biology [Category] COVID-19, [키워드] “COVID-19 “cytokine storm” 20S proteasome acute respiratory syndrome addition analyzed ARDS association AUC Biomarker blood draw cause clinical clinical picture collected Coronavirus-2 Course COVID-19 COVID-19 disease COVID-19 patients COVID-2019 Critical critical appraisal demonstrated described disease disintegration Disseminated intravascular coagulation elevated endpoints evidenced Heat shock help high-risk patient higher risk hospital Hospital admission HSP27 Human hyperinflammation identify immune immune system immunological in-hospital mortality independent indicated Infection Inflammatory Inflammatory cytokine Interpretation invasive ventilation investigated mechanism Mortality notable outbreak oxygen support pandemic pathophysiology Patient patients with COVID-19 plasma Prognostic factor Prognostic factors proteasome Protein Relevance remained Research risk SARS-CoV-2 Sepsis septic patient serological data serum serum sample simple sST2 ST2 subsequent therapeutic interventions undergo Ventilation with COVID-19 [DOI] 10.3390/biology10111186 PMC 바로가기 [Article Type] Article
Current status of therapeutic approaches and vaccines for SARS-CoV-2Special Report Published on 2021-11-112022-10-31 Journal: Future Microbiology [Category] COVID-19, [키워드] Administered antiviral drug antivirals baseline Chloroquine clinical trial clinicians and researcher COVID-2019 current Efficacy Epidemic experimental design FIVE Health help in vitro information inhibitory activity pandemic phase Population Registered Safe SARS-CoV-2 Therapeutic approach therapeutic option Therapeutics Treatment Vaccine Vaccines virus [DOI] 10.2217/fmb-2020-0147 PMC 바로가기 [Article Type] Special Report