Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies실험 및 도킹 연구를 통해 밝혀진 중국 Dagang Tea 성분의 코로나바이러스에 대한 다중 표적 메커니즘Article Published on 2022-10-282022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis antibody antiviral activity Antiviral effect betulinic acid Chemical profile China Chinese Cold colds Compound coronavirus Coronaviruses CPE Cytopathic effect demonstrated docking docking analysis docking study Efficacy enzyme Enzyme inhibition eriodictyol Eurya evaluated exhibited experiment Fever fevers flavonoids Guangdong HCoV-OC43 herbal tea immunofluorescence in vitro infected cells Influenza inhibitory effect Inhibitory effects material mechanism Microscopic monomer naringenin OC43 optical performed PLPro Potential treatment potential treatments Prevent quercetin reduction SARS-CoV-2 tea Traditional Chinese medicine transmission electron microscopy treat Treatment viral infections Virtual screening virus particle virus particles [DOI] 10.1016/j.jep.2022.115528 PMC 바로가기 [Article Type] Article
In vitro inhibition of SARS-CoV-2 Infection by dry algae powdersArticle Published on 2022-10-122022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral property Arthrospira candidate Chlorella COVID-19 CPE Culture DMEM DMSO experiment fucoidan highest in viral in vitro incubated Infection inhibited investigated Post-infection purified reduced Safe Sargassum SARS-CoV-2 SARS-COV-2 infection significantly solvent supernatant TCID therapeutic Treatment Vero Cell viral inoculum Viral RNA was increased was used [DOI] 10.1038/s41598-022-22148-6 PMC 바로가기
Implementation of Chromatic Super CAZ/AVI ® medium for active surveillance of ceftazidime-avibactam resistance: preventing the loop from becoming a spiralceftazidime-avibactam 저항의 능동적 감시를 위한 Chromatic Super CAZ/AVI ® 매체의 구현: 루프가 나선형이 되는 것을 방지Article Published on 2022-09-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] Coronavirus, 유전자 메커니즘, 치료기술, [키워드] Acquired acquired resistance Active surveillance avibactam Bacteria carbapenem Carbapenemase Carbapenemase detection Ceftazidime Ceftazidime-avibactam resistance collected COVID-19 CPE Culture described distribution Endemic Hospitalization ICU implementation increasingly intensive care intensive care unit involved isolate Klebsiella pneumoniae KPC mechanism media medium Mutation non-ICU non-ICU patient non-ICU patients organism Organisms outbreak P. aeruginosa Pathogens Patient pneumoniae Pseudomonas aeruginosa rectal swab reported routine screened sensitivity spiral Spread Strains Surveillance Surveillance culture. susceptible treat [DOI] 10.1007/s10096-022-04480-x PMC 바로가기 [Article Type] Article
Multidrug-resistant OXA-48/CTX-M-15 Klebsiella pneumoniae cluster in a COVID-19 intensive care unit: salient lessons for infection prevention and control during the COVID-19 pandemicResearch article Published on 2022-08-012022-10-05 Journal: The Journal of hospital infection [Category] 변종, [키워드] Appropriate Carbapenemase-producing Enterobacterales Cluster Contact COVID-19 COVID-19 pandemic COVID-19 patients CPE Critical disease doffing donning Escalation finding healthcare healthcare worker hygiene ICU ICUs infection control Infection prevention Infection prevention and control intensive care intensive care patient intensive care unit Intervention isolate Klebsiella pneumoniae measure multidrug-resistant Multidrug-resistant organisms Mutation organism Organisms outbreak outer membrane pathogen Patient patients Personal protective equipment Phylogenetic polymorphism Precaution Prevent Prolonged protocol reduced SARS-CoV-2 screening swab Sequencing Sequencing analysis single nucleotide specimen Surveillance Transmission transmission of SARS-CoV-2 ward with COVID-19 [DOI] 10.1016/j.jhin.2022.05.001 [Article Type] Research article
SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening고처리량 항바이러스 스크리닝을 위한 SARS-CoV-2 허용 교모세포종 세포주Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 Administered Antiviral Antiviral screen cathepsin cathepsin B cathepsin L Cell cell line cell lysis cell monolayer cells cellular cellular infection system circulation Complete contagious CPE Cytopathic effect destruction develop effective evidenced expressed expressing fused Glioblastoma implementation infection with SARS-CoV-2 Nirmatrelvir omicron Permissive preclinical study productive viral replication reduction Remdesivir replicate reported required robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spread tested TMPRSS2 U87 cell line. Vaccine variant virus wild-type virus [DOI] 10.1016/j.antiviral.2022.105342 PMC 바로가기 [Article Type] Article
Repurposing drugs as COVID-19 therapies: A toxicity evaluationCOVID-19 치료제로 약물 용도 변경: 독성 평가Review Published on 2022-07-012022-09-11 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analyzed anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity approved autophagy blockers chemical structures clinical trials contributed correlated COVID-19 CPE Cytopathic effect cytotoxicity database drug drug candidate drug candidates Drug interactions Drug repurposing Efficiency enrolled ether hERG High-throughput screening highlight house identify In vitro assay induce nonspecific pandemic Phospholipidosis profile repurposing SARS-CoV-2 Severe acute respiratory syndrome significantly Structure Toxicity [DOI] 10.1016/j.drudis.2022.04.001 PMC 바로가기 [Article Type] Review
Investigation of Antibody Levels During Three Doses of Sinopharm/BBIBP Vaccine InoculationSinopharm/BBIBP 백신 접종 3회 동안 항체 수준 조사Article Published on 2022-06-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis antibody antibody kinetics antibody levels antibody persistence booster booster dose booster injection chemiluminescent immunoassay CLIA conventional virus neutralization test coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlation Course COVID-19 COVID-19 vaccination CPE Critical cut-off Cytopathic effect detect dose healthcare worker Healthcare workers IgA level IgA levels IgG IgG antibodies IgG antibody IgM Immunity implementation inactivated injection inoculated inoculation investigation Level neutralization test Neutralizing antibodies neutralizing antibody peaked RBD receiver operating characteristic receptor remained respiratory ROC SARS-CoV-2 sensitivity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Sinopharm specific antibodies specificity vaccination Vaccine variety virus neutralization test VNT [DOI] 10.3389/fimmu.2022.913732 PMC 바로가기 [Article Type] Article
Identification, propagation and molecular characterization of SARS-CoV-2 delta variant isolated from Egyptian COVID-19 patients이집트 COVID-19 환자에서 분리된 SARS-CoV-2 델타 변이체의 식별, 전파 및 분자 특성 분석Article Published on 2022-06-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applied B.1.617.2 beta-propiolactone causative agent cell line cell lines characterized China city clade clinically collected continuous monitoring coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CPE Cytopathic effect Delta delta variant diagnosed with COVID-19 effective Effectiveness Efficacy Genetic genetic mutation Genetic variations genome sequence Genome sequences genomic sequence identification inactivated Isolation molecular Mutation rates nasopharyngeal swabs pandemic passage Patient PCR Prevalence Propagation provide qPCR reference strain Replication researcher RT-qPCR SARS-CoV-2 SARS-CoV-2 delta sequence severe acute respiratory syndrome Coronavirus Spread Swab the SARS-CoV-2 transmission rate Treatment protocol Vaccine variant variant of concern variants of concern Variation Vero E6 Vero E6 cell VERO E6 cells viral genome virus VoC was performed WGS whole genome Whole genome sequencing Wuhan-Hu-1 [DOI] 10.1016/j.meegid.2022.105278 PMC 바로가기 [Article Type] Article
Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions해당 억제제 2-deoxy-d-glucose는 숙주 세포에서 SARS-CoV-2 증식을 약화시키고 자손 비리온의 감염 가능성을 약화시킵니다Article Published on 2022-04-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] 2-deoxy-D-glucose 2-DG Analysis attenuate Cell COVID-19 COVID-19 patients CPE Cytopathic effect Effect evaluated examined fluorescent Glucose Glycolysis glycosylation Herpe herpes host cell host cells Infection infective inhibited inhibitor investigated mass spectrometry metabolism nucleocapsid patients phenotype produced progeny virion progeny virions Protein protein expression RBD RdRP RdRp genes Receptor binding domain Receptor-binding domain reduced required resulting RT-PCR SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 spike protein spike Spike protein the receptor-binding domain the spike protein treated Trial Unglycosylation. Vero E6 VERO E6 cells virion virus multiplication was performed [DOI] 10.1016/j.lfs.2022.120411 PMC 바로가기 [Article Type] Article
Development of an immunofluorescence assay for detection of SARS-CoV-2SARS-CoV-2 검출을 위한 면역형광 분석법 개발Article Published on 2022-04-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] 24 hour 24 hours approach assist can not carried Cell culture concentrations COVID-19 pandemic CPE CPE assay CPE assays Culture cultures Cytopathic effect defined demonstrated detect detectable determine development diagnostic test different time points dose etiologic agent identity IFA immunofluorescence assay immunofluorescence assay (IFA Increasing infected with SARS-CoV-2 Infection Infectious virus infectious viruses infective Infective dose Initially nasopharyngeal occur Oropharyngeal pathogen Patient PCR assay positive Postinfection reduced reverse transcription SARS-CoV-2 sensitivity specificity Transmission Vero E6 Vero E6 culture Vero E6 cultures Viral RNA virus transmissibility while [DOI] 10.1007/s00705-022-05392-z PMC 바로가기 [Article Type] Article