Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infectionCellular Response to Infection Published on 2023-12-172024-09-05 Journal: Journal of virology [Category] update2024, [키워드] cell proliferation CRISPR screen interferon SARS-CoV-2 [DOI] 10.1128/jvi.01276-23 PMC 바로가기 [Article Type] Cellular Response to Infection
Conserved requirement of autophagy-related effectors during coronavirus replicationArticle Published on 2023-02-012023-07-10 Journal: Autophagy [Category] COVID19(2023년), [키워드] antiviral target autophagy coronavirus CRISPR screen host factor. [DOI] 10.1080/15548627.2022.2100617
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection게놈 전체에 걸친 양방향 CRISPR 스크린은 뮤신을 SARS-CoV-2 감염을 조절하는 숙주 인자로 식별합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway Antiviral bidirectional cause clathrin conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR screen Critical Defense defense mechanism Epigenetic epithelial cell epithelial cells expression Factor family functional highlight Highlights Host host defense human lung human lung epithelial cells identify in vitro infected individuals Infection inflammatory signaling inhibit mechanism mild respiratory modulating molecular weight mucin mucins murine models Pathways progression provide Regulation respiratory respiratory distress Respiratory illness respiratory viruses SARS-CoV-2 SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point Symptom syndrome the SARS-CoV-2 TMPRSS2 transcriptional Transport Viral viral infection [DOI] 10.1038/s41588-022-01131-x PMC 바로가기 [Article Type] Article
Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2게놈 전체의 CRISPR 화면은 ACE2의 변조를 통해 GATA6을 SARS-CoV-2의 프로바이러스 숙주 인자로 식별합니다.Article Published on 2022-04-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 Alpha Alpha variant Analysis anti-SARS-CoV-2 Beta biogenesis candidate cellular clathrin clinical sample clinical samples collected Comparative analysis component COVID-19 pathogenesis CRISPR CRISPR screen Critical data-set elevated facilitate Factor GATA6 Health heparan sulfate Host host gene host genes identify infected individuals Infection KREMEN2 list loss-of-function modulation pathway pharmacological phosphatidylglycerol regulate required SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection SETDB1 Spread sulfate target therapeutic interventions therapeutic strategy Transcription transcription factor Transport unique variant variants of concern variants of SARS-CoV-2 viral infectivity virus pathogenesis VoC VOCs wild type Zinc [DOI] 10.1038/s41467-022-29896-z PMC 바로가기 [Article Type] Article
Genome-scale CRISPR screens identify host factors that promote human coronavirus infectionResearch Published on 2022-01-272022-10-31 Journal: Genome Medicine [Category] COVID-19, SARS, [키워드] ACE2 Administered airway epithelial cell analyzed Antiviral compound antiviral drug antiviral therapy Cell cell interaction cell line component coronavirus Coronavirus infection Coronavirus replication COVID-19 pandemic CRISPR CRISPR screen death EDC4 effective vaccine expand expressing Factor functional globe HEK293 HEK293T Host human coronavirus OC43 identify Infection involved knockdown knowledge mRNA pathway Pathways performed promote Regulation reported representing Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV2 supplementary material target Vero Vero E6 website were used while XRN1 [DOI] 10.1186/s13073-022-01013-1 PMC 바로가기 [Article Type] Research
Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replicationResearch Article Published on 2021-12-062022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Anti-viral approach Cell contribute contributed coronavirus Coronavirus replication CoV CoV infection CoV replication CoVs CRISPR CRISPR screen Critical disease disease pathogenesis effort Evidence Factor gastroenteritis Health highly pathogenic CoVs Host host gene identification identify Infection inhibit involved kidney performed potential therapeutic target progression Protein provide regulate Replication required reveal RNA virus RNA viruses susceptibility TGEV therapeutic target Tmem41b Vesicle viral infection virus virus replication [DOI] 10.1371/journal.ppat.1010113 PMC 바로가기 [Article Type] Research Article
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactionsArticle Published on 2021-04-292022-10-31 Journal: Cell [Category] COVID-19, MERS, SARS, [키워드] Abstract anti-SARS-CoV-2 Antiviral antiviral activity antiviral immunity antiviral response approach ChIRP-MS Comparative analysis complexes connection CRISPR CRISPR screen CRISPR Screens defined demonstrated Factors functional global mortality highlight highlighting Host host protein host-pathogen interactions identify Immunity Infection integration Interaction majority Mitochondria organelle pandemic pathway physical platform PROTECT Protein protein interaction protein interactions rhinovirus RNA RNA virus RNA-binding proteins RNA-protein complex SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Seven specificity the SARS-CoV-2 Therapeutic benefit These data virus virus-induced cell death [DOI] 10.1016/j.cell.2021.03.012 PMC 바로가기 [Article Type] Article
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactionsBioGRID 데이터베이스: 선별된 단백질, 유전 및 화학적 상호작용의 포괄적인 생물의학 자원Tools for Protein Science Published on 2020-11-232022-09-10 Journal: Protein Science : A Publication of the Protein Soc [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome addition annotation BioGRID Biological biological network Biomedical research build can be used captures carried Cas9 cause cell lines cellular chemical interaction Community Complex network Complex networks COVID‐19 COVID‐19 CRISPR CRISPR screen CRISPR Screens curated database dataset datasets disease drug target drugs example experimental evidence extension facilitate generate Genetic genetic interaction genetic interactions genetic screens Health Human include Interaction interactions Modification mouse open organism phenotype post‐translational modification Protein protein interaction Regulation resource respiratory SARS‐CoV‐2 virus Screen Severe acute respiratory syndrome single mutant small molecule Small molecules species specific disease ubiquitin‐proteasome system worm yeast [DOI] 10.1002/pro.3978 PMC 바로가기 [Article Type] Tools for Protein Science
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 InfectionArticle Published on 2020-10-202023-06-14 Journal: Cell [Category] MERS, SARS, [키워드] COVID-19 CRISPR screen epigenetics HMGB1 MERS-CoV Middle East respiratory syndrome SARS-CoV-2 Severe acute respiratory syndrome SWI/SNF complex [DOI] 10.1016/j.cell.2020.10.028 PMC 바로가기 [Article Type] Article
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules종양 억제제 TMEM127은 Salmonella SteD가 MHC 클래스 II 분자를 유비퀴틴화하고 분해하는 데 필요한 Nedd4 계열 E3 리가제 어댑터입니다.Article Published on 2020-07-082024-08-19 Journal: Cell Host & Microbe [Category] 살모넬라증, [키워드] CRISPR screen dendritic cells lysosomal degradation MHCII Salmonella SteD TMEM127 ubiquitination WWP2 [DOI] 10.1016/j.chom.2020.04.024 PMC 바로가기 [Article Type] Article