Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSARS-CoV-2 항체의 구조 연구는 스파이크 삼량체를 분해하여 오미크론 변이체를 중화하는 광범위한 항체를 식별합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] accommodation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation antibody caused conservation conserved convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo Cryo-electron microscopy cryo-EM develop Effectiveness electron microscopy epitope Epitopes function hidden IgG Immune escape investigated monoclonal antibodies monoclonal antibody NAb NAbs neutralize Neutralizing antibodies neutralizing antibody neutralizing antibody. omicron Omicron variant pandemic Protein pseudovirus raised raising RBD reagent Receptor binding Receptor binding domain respiratory S trimer S trimers SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants steric hindrance subset target the SARS-CoV-2 the Spike therapeutic therapy trimer Vaccines variant variants of SARS-CoV-2 virion virus VoC VOCs [DOI] 10.1128/jvi.00480-22 PMC 바로가기 [Article Type] Article
The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2SARS-CoV와 SARS-CoV-2 사이의 다양한 보존된 에피토프를 표적으로 하는 항체의 중화 폭Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] antibody Antibody therapeutics Beta Beta variant breadth broad neutralizing antibody Candidates class complex conserved conversed epitopes COVID-19 cross-neutralizing antibody cryo Cryo-electron microscopy defined Delta effective electron microscopy epitope Epitopes evade exhibited hamsters immunization Infection Microscopy NAb NAbs neutralization Neutralizing Neutralizing antibodies neutralizing antibody offer omicron Omicron variant Omicron variants pseudoviruses Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody Spike proteins Structure structure. the receptor-binding domain the spike protein Treatment treatment of COVID-19 Vaccine variant variants variants of concern variants of SARS-CoV-2 Viral [DOI] 10.1073/pnas.2204256119 PMC 바로가기 [Article Type] Article
Structure of SARS-CoV-2 membrane protein essential for virus assembly바이러스 조립에 필수적인 SARS-CoV-2 막 단백질의 구조Article Published on 2022-08-052022-09-11 Journal: Nature Communications [Category] SARS, 변종, 치료법, [키워드] analysis component composed conformational changes conformations conserved coronavirus cryo Cryo-electron microscopy domain domains electron microscopy form hinge region Interaction ion channel M protein mechanism membrane protein morphogenesis nucleocapsid protein oligomers ORF3a Protein recruitment RNA SARS-CoV-2 SARS-CoV-2 ORF3a structural protein Structure the SARS-CoV-2 therapeutic intervention transmembrane virus [DOI] 10.1038/s41467-022-32019-3 PMC 바로가기 [Article Type] Article
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge광범위 중화 항체는 SARS-CoV-2 Omicron 공격으로부터 시리아 햄스터를 보호합니다Article Published on 2022-06-232022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 binding addition administration Analysis antibody BNT162b2 compensating conformation cryo Cryo-EM analysis Deletion deletions Delta Delta variants domain Efficacy EM analysis hamster hamsters heavy chain IGHV1-58 Immunotherapy interact Intervention Lung infection Mutation neutralization neutralize neutralizing antibody occurred omicron Omicron variants pandemic Prophylactic PROTECT pseudovirus Receptor-binding domain rescued reveal SARS-CoV-2 SARS-CoV-2 variant spike mutation spike mutations spike trimer target therapeutic Transmissibility Vaccine variant variants Viral viral challenge [DOI] 10.1038/s41467-022-31259-7 PMC 바로가기 [Article Type] Article
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope35B5 항체는 보존된 스파이크 에피토프를 통해 N-글리칸 스위치를 방해하여 SARS-CoV-2 Omicron을 강력하게 중화합니다.Article Published on 2022-06-082022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 35B5 ACE2 antibody antigenic antigenic shift change changes conformational change conserved Control cryo Cryo-electron microscopy disrupting dissociation domain Efficacy electron microscopy entry receptor epitope exhibit Extracellular Fab glycan Host immune evasion Microscopy monoclonal monoclonal antibody Mutation N-terminal domain neutralization neutralize Neutralizing Neutralizing antibodies neutralizing capacity not affect NTD omicron other variant other variants RBD Receptor-binding domain Recognition SARS-CoV-2 Spike protein spike protein. Structure the RBD the spike protein therapeutic transition trimer trimeric variant [DOI] 10.1016/j.chom.2022.03.035 PMC 바로가기 [Article Type] Article
Structural diversity of the SARS-CoV-2 Omicron spikeSARS-CoV-2 오미크론 스파이크의 구조적 다양성Article Published on 2022-06-022022-09-11 Journal: Molecular Cell [Category] COVID19(2023년), SARS, 변종, [키워드] affecting Analysis changes in communication conformational conformational change Critical cryo Cryo-electron microscopy cryo-EM structure cryo-EM structures Crystallography Delta delta variant determine domain dominant electron microscopy epitope fusion peptide immune immune evasion Impact interprotomer communication intraprotomer communication Mutation Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron spike peptide RBD Receptor-binding domain SARS-CoV-2 evolution spike Spike protein the SARS-CoV-2 Transmissibility variant vector analysis. virus transmissibility X-ray X-ray crystallography [DOI] 10.1016/j.molcel.2022.03.028 PMC 바로가기 [Article Type] Article
Structures of Omicron spike complexes and implications for neutralizing antibody developmentOmicron 스파이크 복합체의 구조 및 중화 항체 개발에 대한 의미Article Published on 2022-05-032022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 antibodies antibody Antibody binding Antibody structure binding biochemical complexes country CP: Immunology CP: Microbiology cryo Cryo-electron microscopy cryo-EM cryo-EM structures Delta dominant drugs electron microscopy Evidence explain Fab immune immune evasion immunology implication information interactions lead Microbiology Mutation mutations neutralization Neutralization antibody neutralization assays neutralizing antibody omicron provide required responsible SARS-CoV-2 spike spike mutation spike mutations Spike. Structure structures the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine variant wild-type [DOI] 10.1016/j.celrep.2022.110770 PMC 바로가기 [Article Type] Article
Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants단봉 낙타 나노바디는 SARS-CoV-2 변종을 광범위하게 중화시킵니다.Article Published on 2022-05-032022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin antibodies antibody apex B.1.351 B.1.617.2 bind CDR3 complex structure conformational coronavirus coronavirus CoV COVID-19 cryo cryo-EM Cryoelectron microscopy dose Dromedary dromedary camel nanobody VHH Epitopes expressing hACE2 heterodimer high affinity human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 humans involved MERS-CoV Middle East Middle East respiratory syndrome Middle East Respiratory Syndrome CoV nanobodies nanobody neutralization activity neutralize Neutralizing neutralizing antibody nonoverlapping epitope nonoverlapping epitopes platform Protein RBDs Receptor-binding domain receptor-binding domains recognize reservoir residue S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single-domain antibody. syndrome target the RBD the S1 subunit therapeutic use transgenic mice transmitted trimer unique variant variants variants of concern viruses [DOI] 10.1073/pnas.2201433119 PMC 바로가기 [Article Type] Article
Structural and functional impact by SARS-CoV-2 Omicron spike mutationsSARS-CoV-2 오미크론 스파이크 돌연변이에 의한 구조적 및 기능적 영향Article Published on 2022-04-262022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter antigenic antigenic structure cellular tropism coronavirus country CP: Molecular biology cryo cryo-EM dominant evade full-length functional host immunity host receptor membrane fusion Molecular biology mutations N-terminal domain Neutralizing antibodies not seen omicron Omicron variant other variants prevalent Protein Receptor-binding domain S protein SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus spike mutation Spike protein structure. the receptor-binding domain the S protein variant variants [DOI] 10.1016/j.celrep.2022.110729 PMC 바로가기 [Article Type] Article
Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron치명적인 SARS-CoV-2 감염 표적 수용체 결합 에피토프로부터 보호하는 나노바디는 오미크론 이외의 바이러스 변이체에 보존되어 있습니다Article Published on 2022-04-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] affinity antibody binding binding epitope binding mode blocked cell cultures cell entry cell entry receptor competition coronavirus COVID-19 COVID-19 pandemic cryo Cryo-electron microscopy electron microscopy Epitopes fusion glycoprotein groups hACE2 heavy chain human ACE2 humanized immune Immune escape immunized lethal mice Microscopy mono MOST nanobodies nanobody neutralization neutralized Neutralizing Neutralizing antibodies neutralizing antibodies. neutralizing antibody nine omicron Other Prevent prevented progression Protecting pseudotyped RBD RBD binding RBM receptor receptor binding motif Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants selected target the receptor-binding domain the S protein therapeutic potential Therapeutics Vaccine variant variants of concern virus virus [DOI] 10.3389/fimmu.2022.863831 PMC 바로가기 [Article Type] Article