Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapyArticle Published on 2022-02-072022-10-04 Journal: NPJ Systems Biology and Applications [Category] 바이오마커, [키워드] ACTBL2 Biomarker Biomarkers Cancer candidate Characteristics Combination Computational biology and bioinformatics CTCF CTCFL cytoplasmic membrane de novo Diagnosis driving effective enrichment analysis evaluate expressed females function HGSC High-grade Improving in vitro model involved ITGB3 ITGB6 lack malignancy MALT1 molecular ovarian ovarian cancer Pathomechanism pathway PCDH7 predict prognostic Prognostic marker progression regulate Regulatory resulting survival target target gene targeted therapy targets therapeutic potential therapy tissue transcriptional transcriptional change Treatment VEGFA [DOI] 10.1038/s41540-022-00214-z PMC 바로가기 [Article Type] Article
A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19CTCF 결합을 방해하는 인터루킨-6의 저생산 일배체형은 심각한 COVID-19를 예방합니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, [키워드] 95% confidence interval allele Analysis antisense Asia Asian bidirectional transcription carrier carriers Chinese conserved correlated COVID-19 COVID-19 patient COVID-19 severity CTCF defined Disease progression disturbance element Endemic enhancer expression functional genetic polymorphisms Genotype Haplotype Human humans hyperinflammation IL-6 IL-6 blockade IL-6 expression induce Inflammatory responses inflammatory stimuli interleukin-6 intronic SNP intronic SNPs loci locus long noncoding RNA lower risk Mild Neanderthal Odds ratio outcome patients polymorphism Polymorphisms promoter Protective Quantitative reduced severe symptom severe symptoms severity significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs T allele therapy transcribed Variability variant Viral viral infection with COVID-19 [DOI] 10.1128/mBio.01372-21 PMC 바로가기 [Article Type] Research Article
The CCCTC-binding factor CTCF represses hepatitis B virus enhancer I and regulates viral transcriptionArticle Published on 2021-02-042023-06-03 Journal: Cellular microbiology [Category] B형 간염, [키워드] CTCF epigenetics HBV transcription insulation transcription regulation [DOI] 10.1111/cmi.13274 PMC 바로가기 [Article Type] Article