Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factorsPCOS가 있는 여성의 난소 과립막 세포는 낮은 수준의 SARS-CoV-2 수용체 및 보조 인자를 발현합니다Article Published on 2022-08-012022-09-11 Journal: Archives of gynecology and obstetrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus BSG cardiovascular disease Cell cell types co-morbidities controls coronavirus COVID-19 CTSB CTSL datasets death diabetes DPP4 Express expresse expression Factor feature global pandemic granulosa healthy help Human in vitro In vitro fertilization indicate Infection investigated IVF knowledge Lower lower expression material Microarray microarray data morbidities obesity Oocyte organ ovarian ovarian follicle Ovarian granulosa cells Ovary pandemic PCOS polycystic ovary protease receptor reproductive risk Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility susceptible syndrome tissue TMPRSS2 Type-2 diabetes mellitus women [DOI] 10.1007/s00404-022-06567-4 PMC 바로가기 [Article Type] Article
Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular [DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article
Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma카텝신 B는 폐 선암종을 가진 코로나바이러스 질병 2019 환자를 위한 잠재적인 치료 표적입니다Article Published on 2022-02-012022-09-11 Journal: Chemico-biological interactions [Category] 바이오마커, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Atla available data Basigin bioinformatics cancers cathepsin cathepsin B cause Cell coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CTSB database determine diagnosed with COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 drug therapy explain expressed expression Gene Expression Omnibus GEO global public health Hyperinflammatory Hyperinflammatory response identify Immune cell infiltration implicated lung adenocarcinoma lung cancer lung cancer patient lung cancer patients mortality rate outcome Patient patients patients with COVID-19 positively correlated potential therapeutic target presenting Proinflammatory cytokine SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility the SARS-CoV-2 therapeutic target therapy for COVID-19 tissue upregulation [DOI] 10.1016/j.cbi.2022.109796 PMC 바로가기 [Article Type] Article
Exploring Toxins for Hunting SARS-CoV-2 Main Protease Inhibitors: Molecular Docking, Molecular Dynamics, Pharmacokinetic Properties, and Reactome StudyArticle Published on 2022-01-272022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Analysis binding affinity binding energy biochemical characterized Combination conducted COVID-19 patient CTSB CTSK CTSL database Dynamics enzyme hunting IL-13 IL-4 in silico in silico screening include inhibitor Ligand M pro matrix metalloproteinase MD simulations molecular molecular docking molecular docking calculations molecular dynamics (MD) simulations Pathway enrichment analysis Prevent protease provide Reactome SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication screened severe lung injury Signaling toxin toxins [DOI] 10.3390/ph15020153 PMC 바로가기 [Article Type] Article
Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer PatientsBioengineering and Biotechnology Published on 2022-01-262022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] acute respiratory syndrome bioinformatic analysis Cancer cancer patient cancer tissue cathepsin cell lines Comprehensive coronavirus correlated correlation CTSB CTSL death digestive distribution expressed expression facilitate Gallbladder Genetic host cells Immune cell infiltration immune infiltration in healthy individual individual infect investigated kidney tissue liver Lungs novel overexpressed Prognosis Prognostic value protease Proteases reported SARS-CoV-2 SARS-COV-2 infection significantly suggested susceptible tissues translational [DOI] 10.3389/fbioe.2022.780751 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium선입견 인간 자궁 내막에서 SARS-CoV-2 세포 진입 인자의 단일 세포 RNA 시퀀싱Article Published on 2021-09-182022-09-11 Journal: Human reproduction (Oxford, England) [Category] SARS, 치료기술, [키워드] ACE2 Analysis ANPEP Asymptomatic COVID-19 Biohub biopsy board BSG canonical carriers caution CD209 Cell cell entry cell type cells chance CLEC4G Cohort conducted COVID-19 CTSB CTSL dataset Donor during pregnancy early pregnancy Efficiency epithelial cell epithelial cells European examined expressed expression expression of gene Factor Focusing framework furin Gene Expression Gene Expression Omnibus head healthy Horizon IFITM1 implication Infection Innovation luminal LY6E menstrual menstrual cycle Miguel NCBI NRP1 offer Pregnancy processed Program proliferative Proteases protein expression raw data receptor receptor ACE2 reported reproductive resource reveal risk risk of infection RNA sequencing SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 receptor scRNAseq Sequence Read Archive single-cell level Single-cell RNA-sequencing Spanish Stanford stromal cells supported the SARS-CoV-2 tissue TMPRSS11A TMPRSS2 TMPRSS4 transcriptomics transmission of SARS-CoV-2 Type union vertical transmission viral infection virus [DOI] 10.1093/humrep/deab183 PMC 바로가기 [Article Type] Article
Management of Patients With Glucocorticoid-Related Diseases and COVID-19글루코코르티코이드 관련 질환 및 COVID-19 환자 관리Review Published on 2021-09-142022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration Adrenal insufficiency adrenocortical carcinoma affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anticancer binding Cancer caused circulating cleaved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTSB CTSL Cushing’s syndrome cushing’s syndrome cytokine Cytokine storm Endocrine enzyme expressed furin gastrointestinal tract genes encoding glucocorticoid Glucocorticoids group Health Health crisis host cell host cells hyperaldosteronism immune response Immunosuppressant immunosuppressants immunosuppressive in silico analysis Infection inhibitory effect kidney lung management mRNA expression outcome pandemic pathophysiological mechanism Patient Pituitary protease respiratory SARS-CoV-2 secreted Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility the cytokine storm the timing tissues TMPRSS2 transmembrane transmembrane protease serine 2 Tumor tumors [DOI] 10.3389/fendo.2021.705214 PMC 바로가기 [Article Type] Review
Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell LevelCommentary Published on 2021-06-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] ACE2 Adults analyzed Cell cell type children Clinical symptoms construction COVID-19 COVID-19 infection CTSB CTSL explain expression level expression pattern Factor fetal FIVE global pandemic Host Human Infection Injury landscape Level mechanism MTHFD1 organ organs risk SARS-CoV-2 single-cell RNA-seq Symptoms symptoms of COVID-19 TMPRSS2 [DOI] 10.14336/AD.2021.0301 PMC 바로가기 [Article Type] Commentary
Genome‐wide screening of SARS‐CoV‐2 infection‐related genes based on the blood leukocytes sequencing data set of patients with COVID‐19Research Article Published on 2021-05-282022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome adverse effect Analysis analyzed AUC AUC value bioinformatics blood leukocyte calculated caused contribute coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 CTSB CTSL DEGs Diagnosis diagnostic differentially expressed gene disease enrichment analysis Epidemic EPSTI1 expressed expression function Gene ontology GEO database Health IFI27 IFIT3 leukocyte Logistic regression analysis mechanism OASL Patient positively correlated Protein–protein interaction risk ROC Curve SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 screened sequencing data therapeutic therapeutic target TMPRSS2 Treatment USP18 virus XAF1 [DOI] 10.1002/jmv.27093 PMC 바로가기 [Article Type] Research Article
Susceptibility of neuroblastoma and glioblastoma cell lines to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 신경모세포종 및 교모세포종 세포주의 감수성Article Published on 2021-05-012022-09-11 Journal: Brain research [Category] SARS, 치료기술, [키워드] Analysis Apoptosis Cell cell line cell lines cell type cells Coronavirus-2 CTSB CTSL Cytopathic effect death demonstrated described downregulation epithelial cell epithelial cells Express Gene Expression Genes Glioblastoma Glutamate idea In situ hybridization infected cell infected cells Infection maintain MOI MOIs Neuroblastoma neuronal neurotropism Perspective quantification replicate retinoic acid RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 SH-SY5Y susceptibility tropism upregulation Vero E6 VERO E6 cells virus were expressed were infected [DOI] 10.1016/j.brainres.2021.147344 PMC 바로가기 [Article Type] Article