Single-cell analysis of adult human heart across healthy and cardiovascular disease patients reveals the cellular landscape underlying SARS-CoV-2 invasion of myocardial tissue through ACE2article Published on 2023-05-312024-09-05 Journal: Journal of Translational Medicine [Category] update2024, [키워드] ACE2 ADAM17 COVID-19 CTSL heart SARS-CoV-2 scRNA-seq [DOI] 10.1186/s12967-023-04224-1 PMC 바로가기 [Article Type] article
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factorsPCOS가 있는 여성의 난소 과립막 세포는 낮은 수준의 SARS-CoV-2 수용체 및 보조 인자를 발현합니다Article Published on 2022-08-012022-09-11 Journal: Archives of gynecology and obstetrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus BSG cardiovascular disease Cell cell types co-morbidities controls coronavirus COVID-19 CTSB CTSL datasets death diabetes DPP4 Express expresse expression Factor feature global pandemic granulosa healthy help Human in vitro In vitro fertilization indicate Infection investigated IVF knowledge Lower lower expression material Microarray microarray data morbidities obesity Oocyte organ ovarian ovarian follicle Ovarian granulosa cells Ovary pandemic PCOS polycystic ovary protease receptor reproductive risk Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility susceptible syndrome tissue TMPRSS2 Type-2 diabetes mellitus women [DOI] 10.1007/s00404-022-06567-4 PMC 바로가기 [Article Type] Article
Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular [DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Research Published on 2022-06-062022-10-05 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] activated acute respiratory syndrome approach blocked cathepsin Cell cleavage site conformations conserved coronavirus CTSL CTSL cleavage demonstrated domain Effect Ex vivo exhibited experiment host protease human donor Infection inhibitor Live virus lung tissue mechanism membrane fusion mice mutated novel omicron Prevent promoted Protein pseudovirus RBD reduced S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants strain the S protein therapy Treatment treatment strategy Vaccine variant viral infection virus [DOI] 10.1038/s41421-022-00419-w [Article Type] Research
Potential Antiviral Strategy Exploiting Dependence of SARS-CoV-2 Replication on Lysosome-Based Pathway리소좀 기반 경로에 대한 SARS-CoV-2 복제의 의존성을 악용하는 잠재적인 항바이러스 전략Review Published on 2022-05-312022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anti-SARS-CoV-2 correlation country COVID-19 CTSL CTSL activities dependence disease drug effective eukaryotic cells exit experimental evidence lack life cycle lysosomal lysosomal acidification lysosomal function. Lysosomes moderate Novel coronavirus outbreak pathway Potential public health regions Replication required SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 replication SARS-CoV-2 variant severe COVID-19 patients shown Strategy Support the SARS-CoV-2 Treatment variant virus entry [DOI] 10.3390/ijms23116188 PMC 바로가기 [Article Type] Review
Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategyResearch article Published on 2022-05-172022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, 치료법, 치료제, [키워드] activate acute respiratory syndrome antibiotic applied approach binding can be used cathepsin cathepsin L cleave clinically coronavirus coronavirus disease COVID-19 CTSL cysteine protease Daptomycin deep learning drug Drug discovery drug prediction enzyme expand FDA-approved drug identify Infection inhibit inhibit SARS-CoV-2 inhibitor inhibitory effect live SARS-CoV-2 molecular docking novel molecule other disease Potential predict pseudotype pseudovirus infection robust SARS-CoV-2 significantly small molecule Spike protein suggested therapeutic target these compound Treatment Z-FA-FMK [DOI] 10.1016/j.csbj.2022.05.023 [Article Type] Research article
Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory TractArticle Published on 2022-04-162023-07-08 Journal: Viruses [Category] COVID19(2023년), [키워드] ACE2 air–liquid interface animals CTSL primary cell cultures respiratory tract SARS-CoV-2 tissue explants TMPRSS2 zoonosis [DOI] 10.3390/v14040828 PMC 바로가기
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2COVID-19 수용체 및 악성 암: SARS-CoV-2에 대한 감수성과 CTSL 발현의 연관성Article Published on 2022-03-062022-09-11 Journal: International Journal of Biological Sciences [Category] SARS, 변종, [키워드] A549 ACE2 ACE2 mRNA Analysis analyzed Cancer cancer cell line cancer cell lines cancer patient Cancer patients cancer progression cancer tissue cancers conserved cordycepin Cordycepin (CD) correlated correlation COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 severity COVID-19 treatment Critical CTSL cysteine disease domain dose ENCODE evaluate expressed expression furin glioma highest Human IHC immunohistochemistry inhibit inhibited isoform lung lung cancer lung tissue Lungs lysosomal malignant Malignant cancers modulating MONITOR mRNA expression mutant Mutation mutation rate N6, N6-dimethyladenosine (m62A) other proteases outcome Pathogenesis Patient PC3 performed predict prevalent Proteases Protein proteinase receptor regulate Regulation SARS-CoV-2 SARS-CoV-2 entry significantly survival susceptibility The CTSL gene. therapeutic potential These data tissue tissues TMPRSS2 Treatment Tumor tumor progression western blot [DOI] 10.7150/ijbs.70172 PMC 바로가기 [Article Type] Article
Expressions and significances of CTSL, the target of COVID-19 on GBMCTSL의 표현 및 중요성, GBM에서 Covid-19의 목표Article Published on 2022-03-012022-08-31 Journal: Journal of cancer research and clinical oncology [Category] MERS, SARS, 바이오마커, [키워드] analyzed Apoptosis association B cell biological activity Brain tissues cathepsin cathepsin L CD8 Cell Coronavirus infection correlated COVID-19 CTSL database expression level Glioblastoma glioblastoma multiforme growth Immune cell infiltration immune infiltration independent Infection inhibitor investigated mitochondrial New coronavirus overall survival Patient patients Prognosis Prognostic factor Proteases purity reduced risk significantly significantly lower subsequent survival survival rate T cell the cell therapeutic target tissue virus was tested [DOI] 10.1007/s00432-021-03843-9 PMC 바로가기 [Article Type] Article