Design and analysis considerations for early phase clinical trials in hepatitis B (HBV) cure research: the ACTG A5394 study in persons with both HIV and HBVOriginal Research Published on 2023-08-242024-09-05 Journal: Journal of Virus Eradication [Category] update2024, [키워드] Clinical trial design cure HBV HIV Placebo TLR agonist [DOI] 10.1016/j.jve.2023.100344 PMC 바로가기 [Article Type] Original Research
Depleting hepatitis B virus relaxed circular DNA is necessary for resolution of infection by CRISPR-Cas9Original Article Published on 2023-02-042024-09-05 Journal: Molecular Therapy. Nucleic Acids [Category] update2024, [키워드] antiviral therapy Cas9 RNPs cccDNA elimination Chronic Hepatitis B cure DNA methylation epigenetics MT: RNA/DNA Editing reverse transcription Viral rebound [DOI] 10.1016/j.omtn.2023.02.001 PMC 바로가기 [Article Type] Original Article
Characterisation of SARS-CoV-2 clades based on signature SNPs unveils continuous evolution시그니처 SNP를 기반으로 한 SARS-CoV-2 분기군 특성화, 지속적인 진화 공개Article Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] A97V Amino acid amino acid change amino acid changes biological function Biological functions carried change changes in Characteristics clade clades Cluster COVID-19 cure dataset Deleterious Deleterious mutations evaluate Evolution form Frequency globe identify MAFFT Multiple sequence alignment Mutation Nextstrain Non-synonymous Non-Synonymous Signature SNP NSP2 nsp4 nucleocapsid Occurrence ORF3a performed phylogenetic analyses Phylogenetic analysis PolyPhen-2 Protein protein structure PROVEAN Q57H RdRP Research responsible SARS-CoV-2 SARS-CoV-2 genome sequence Sequence alignment sequences signature SNP SNPs Spread stability strain T85I unique unique SNP unique SNPs used to evaluate vaccination Vaccine virus virus genome virus strain virus strains Wuhan Wuhan, China [DOI] 10.1016/j.ymeth.2021.09.005 PMC 바로가기 [Article Type] Article
Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between patients experiencing mild and severe symptoms모델링은 SARS-CoV-2 감염의 이질적인 결과를 요약하고 경증 및 중증 증상을 경험하는 환자 간의 타고난 면역 및 CD8 T 세포 반응의 차이를 정량화합니다.Article Published on 2022-06-272022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory distress applied Arm ARMS CD8 T-cell CD8 T-cell response CD8 T-cell responses clinical observations concert cure dataset death elicit empirical evidence entire spectrum estimate exhibiting feature heterogeneous heterogeneous outcome immune implication in viral indicated Infection innate immune innate immune response Intervention mathematical mathematical model Mild modeling Occurrence offered outcome outcomes parameter Patient provided Quantitative recrudescence respiratory distress SARS-CoV-2 SARS-COV-2 infection severe disease Severe infection severe symptom Symptom T-cell Response Variability Viral load Viral variants without symptom [DOI] 10.1371/journal.ppat.1010630 PMC 바로가기 [Article Type] Article
Crystal-structures-guided design of fragment-based drugs for inhibiting the main protease of SARS-CoV-2SARS-CoV-2의 주요 단백질 분해효소를 억제하기 위한 단편 기반 약물의 결정 구조 유도 설계Article Published on 2022-05-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 치료제, [키워드] active site approved binding free energy caused comparable contagious COVID-19 COVID-19 pandemic cure derivative drug drug candidate drug design Drug discovery FDA fragment fragment-based drug design free energy globe infected patients Infectious disease inhibiting Ligand main protease molecular docking molecular dynamics Molecular dynamics simulation MPro principle processed protease Protein resolved SARS-CoV-2 SARS-CoV-2 virus the SARS-CoV-2 virus treat [DOI] 10.1002/prot.26260 PMC 바로가기 [Article Type] Article
Ultrasensitive detection and quantification of viral nucleic acids with Raindance droplet digital PCR (ddPCR)Raindance droplet 디지털 PCR(ddPCR)을 사용한 바이러스 핵산의 초고감도 검출 및 정량화Article Published on 2022-05-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal models Antiretroviral therapy approaches assays caused Cell Combination cure Cure research ddPCR detect Detection sensitivity diagnosis and monitoring digital PCR disease DNA and RNA Efficacy example highlighting HIV HIV prevention HIV-1 HIV-1 infection HIV-1 viral immunodeficiency virus infected individual infected individuals Infection Infectious disease Infectious diseases inhibition inhibitors Interpretation model systems NHP non-human primate nucleic acid Nucleic acid detection nucleic acids outcome platform predictor progression quantification quantitation Raindance reduced required Research reverse transcription rhesus macaque rhesus macaques RNA RT-ddPCR SARS-CoV2 sensitive Simian simian immunodeficiency virus SIV step tissue tissues Treatment treatment intervention treatment interventions viral DNA viral nucleic acid viral nucleic acid detection viral nucleic acids Viral reservoir virus viruses [DOI] 10.1016/j.ymeth.2021.04.025 PMC 바로가기 [Article Type] Article
Optimizing antiviral therapy for COVID-19 with learned pathogenic model학습된 병원성 모델로 COVID-19에 대한 항바이러스 요법 최적화Article Published on 2022-04-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 임상, 치료기술, 치료법, 치료제, [키워드] Antiviral antiviral therapy antivirals caused Clinical data clinical trial clinical trials COVID-19 cure dose Efficacy fatality followed by healthcare Healthcare industry immune in sight Mental multi multitude Pathogenesis pathogenesis of SARS-CoV-2 pathogenic predict reduction in Remdesivir schedule severe COVID-19 patient severe COVID-19 patients sight T cell T cells therapy toxicities treated variant variants Virological [DOI] 10.1038/s41598-022-10929-y PMC 바로가기 [Article Type] Article
Immunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19?면역 요법 및 CRISPR Cas 시스템: COVID-19의 잠재적 치료?Review Published on 2022-03-302022-09-11 Journal: Drug design, development and therapy [Category] MERS, SARS, 변종, 진단, [키워드] affected antibody CAR-T caused Cell cells circumvent clustered regularly interspaced short palindromic repeat condition convalescent plasma COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 treatment CRISPR CRISPR Cas cure degrade Disease progression feasible human body human immune response hypothese hypotheses Immune cell immune cells immune response immune responses Immunity Immunotherapy individual infected individuals Infection Mild natural infection Neutralizing antibodies neutralizing antibody NK cells overcome pandemic Potential Prevent problem progression question raise risk SARS-CoV-2 SARS-COV-2 infection Severe case Side effects specificity Stage T cells treat Treatment Vaccine variants of concern Viral Viral RNA [DOI] 10.2147/DDDT.S347297 PMC 바로가기 [Article Type] Review
Four Weeks Treatment with Glecaprevir/Pibrentasvir + Ribavirin-A Randomized Controlled Clinical Trial글레카프레비르/피브렌타스비르 + 리바비린-A 무작위 대조 임상 시험으로 4주간 치료Randomized Controlled Trial Published on 2022-03-162022-09-11 Journal: Viruses [Category] 임상, 치료제, [키워드] analyzed baseline chronic hepatitis chronic hepatitis C clinical Controlled Controlled trial Course COVID-19 pandemic cure DAA eight Enhancing fibrosis Genotype glecaprevir HCV Health Organization Hepatitis hepatitis C intention to treat Liver fibrosis multicenter naïve open label Patient patients treated pibrentasvir predictor predictors Randomized Randomized controlled trial reducing ribavirin stratified sustained Treatment Trial Viral load virological response Week World Health Organization [DOI] 10.3390/v14030614 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical features, management, and outcome of hemodialysis patients with SARS-CoV-2SARS-CoV-2 혈액투석 환자의 임상 양상, 관리 및 결과Article Published on 2022-02-012022-09-11 Journal: Therapeutic apheresis and dialysis : official peer [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Adult age AST Chest CT chronic renal failure clinical clinical feature Clinical features clinical manifestations Clinical outcome Comorbidity COVID-19 COVID-19 infection CRP level CRP levels cure demographic determine diagnosed died discharged Dyspnea enrolled eosinophil eosinophil counts evaluate evaluated fatigue feature Features Hemodialysis intensive care intensive care unit laboratory data lesion management Mortality mortality rate Older Older age outcome Patient patients patients died patients with SARS-CoV-2 Platelet Potassium prognostic Prognostic factors Prospective Study renal renal failure risk factor SARS-CoV-2 Seven single-center survived Symptom the patient transferred troponin two group two groups with COVID-19 [DOI] 10.1111/1744-9987.13696 PMC 바로가기 [Article Type] Article