Contribution of non-steroidal anti-inflammatory drugs to breast cancer treatment: In vitro and in vivo studiesReview Article Published on 2024-05-152024-09-05 Journal: Veterinary World [Category] update2024, [키워드] Breast cancer Chemoprevention COX-2 Cyclooxygenase experimental studies NSAIDS [DOI] 10.14202/vetworld.2024.1052-1072 PMC 바로가기 [Article Type] Review Article
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot [DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
Identification of potentially anti-COVID-19 active drugs using the connectivity MAP연결 맵을 사용하여 잠재적으로 항 -CovID-19 활성 약물의 확인Research Article Published on 2022-01-272022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activating AMPK Analysis Anti-inflammatory applied Cancer cells catabolic Cell characterization Compound connectivity coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cyclooxygenase database deleterious effect deleterious effects Dexamethasone drug Drug repurposing emergency response favor fluorometholone gene expression profile Gene expression profiles generate glucocorticoid Glucocorticoid receptor growth identification identify infected cells interfere involved lipid metabolism Map MDM2 metabolism modulate nitric oxide nitric oxide synthase organism Other other compounds Oxide p53 pandemic pathway proliferative reaction receptor resource respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tissue Transmission treat virus [DOI] 10.1371/journal.pone.0262751 PMC 바로가기 [Article Type] Research Article
Etoricoxib may inhibit cytokine storm to treat COVID-19Etoricoxib는 COVID-19를 치료하기 위해 사이토카인 폭풍을 억제할 수 있습니다Article Published on 2021-05-012022-09-11 Journal: Medical Hypotheses [Category] 신약개발, [키워드] absence arachidonic acid caused conversion COVID-19 Cyclooxygenase Cytokine storm drug Etoricoxib IL-6 inhibit NSAID patients potential treatments present prostaglandin reducing spread of COVID-19 treat Vaccines [DOI] 10.1016/j.mehy.2021.110557 PMC 바로가기 [Article Type] Article
Cyclooxygenase 2 and vascular endothelial growth factor-potential targets to manage lepra reactions: A case-control studyarticle Published on 2021-03-312024-09-01 Journal: Dermatologic Therapy [Category] 한센병, [키워드] Cyclooxygenase lepra reaction leprosy skin vascular endothelial growth factor [Article Type] article
Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury7-케토콜레스테롤에 의한 내피 손상에 대한 에르고티오네인의 효과Article Published on 2021-03-012022-09-11 Journal: Neuromolecular medicine [Category] 신약개발, [키워드] 7-Ketocholesterol addition animals Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects antioxidant Apoptosis Bacteria blood-brain barrier Blood–brain barrier Brain cardiovascular disease Cell cell viability cholesterol claudin claudin-5 CNS complications coronavirus COVID-19 COX2 cross Cyclooxygenase Cytokines Dementia diabetes diet Diseases dose-dependent Effect Eicosanoids Endothelial cell endothelial cells enzymatic activity Ergothioneine excitotoxicity Extracellular Free Free radicals fungi Human brain humans IL-1β IL-6 IL-8 increase in increases in Incubation induce Inflammation inhibitor management mRNA expression Mushrooms Necrosis neurodegenerative Neuroinflammation neurologic Neurovascular Neutralizing NF-kB nucleus nutraceutical oxidative stress Oxysterols Patient pro-inflammatory cytokines produced protective effect Proteins reduced significantly stroke thought tight junction Tight junction proteins TNF-α unlikely Vascular vascular dementia viability ZO-1 zonula zonula occludens [DOI] 10.1007/s12017-020-08620-4 PMC 바로가기 [Article Type] Article
Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19세파란틴: COVID-19에서 일본 승인 탈모증 약물의 항바이러스 가능성 검토Review Published on 2020-07-222022-09-10 Journal: Pharmacological Reports [Category] MERS, SARS, 신약개발, 치료제, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Against Anti-inflammatory Antioxidative antiparasitic Antiviral antiviral agent antiviral properties approved candidate caused Cepharanthine choice clinically combating coronavirus coronavirus inhibitor COVID-19 COVID-19 cases Cyclooxygenase cytokine cytokine production demonstrated drug drug of choice Evidence expression Hayata homologous immunomodulating Inflammatory response inhibit lipid peroxidation NF-κB nitric oxide nuclear Replication respiratory SARS-CoV-2 Stephania suppresse therapeutic therapeutic potential unique Viral viral entry viral replication virus viruses [DOI] 10.1007/s43440-020-00132-z PMC 바로가기 [Article Type] Review
Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino ratsArticle Published on 2018-08-312024-09-02 Journal: InflammoPharmacology [Category] 백일해, 파상풍, [키워드] autism Cyclooxygenase interleukin lipopolysaccharide Lipoxygenase Paracetamol PMC 바로가기
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infectionShort Report Published on 2007-06-072022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] affected appear blocking coronavirus COX Cyclooxygenase different different cells early stage Infection inhibitor investigated MHV mouse hepatitis mouse hepatitis virus Pathogenesis progeny reduced Replication required RNA interference subsequent therapy viral infection Viral protein Viral RNA virus production [DOI] 10.1186/1743-422X-4-55 PMC 바로가기 [Article Type] Short Report