Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agentsReview Published on 2022-05-212023-07-01 Journal: Drug discovery today [Category] COVID19(2023년), SARS, [키워드] Antiviral cyclophilin A cyclosporin A Debio-025 Drug repurposing [DOI] 10.1016/j.drudis.2022.05.016 PMC 바로가기 [Article Type] Review
Cyclosporine A Inhibits Viral Infection and Release as Well as Cytokine Production in Lung Cells by Three SARS-CoV-2 VariantsCyclosporine A는 3가지 SARS-CoV-2 변이체에 의한 폐 세포의 바이러스 감염 및 방출 및 사이토카인 생성을 억제합니다Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Anti-inflammatory anti-inflammatory drug anti-SARS-CoV-2 vaccines Antibody neutralization Antiviral antiviral activity approach approach approved B.1.1.7 benefit Betacoronavirus Betacoronavirus genus Calu3 CaLu3 cells Cell cellular mechanism cellular mechanisms coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients CsA cyclophilin cyclophilin A cyclosporine cyclosporine A cytokine cytokine release Cytokine storm Cytokines dampen death in COVID-19 decrease diffusion disease severity drug Effect Effectiveness exposure to expression Hyperactivation IL-6 IL-8 immune system infected cells Infection interleukin involved knock lung cell lung cells organ P.1 pandemic Patient patients Production progeny virion progeny virions Protein protocol rationale reduce reduce mortality Release released repositioning repurposing respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe COVID-19 patients severe symptom severe symptoms tested therapeutic These data TNF-α transmissible variants treat Treatment variants Viral viral infection Viral RNA viral strain viral strains well [DOI] 10.1128/spectrum.01504-21 PMC 바로가기 [Article Type] Research Article
[Role of cyclophilin A during coronavirus replication and the antiviral activities of its inhibitors]Review Published on 2020-04-252023-07-13 Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Category] SARS, [키워드] Coronaviruses cyclophilin A cyclosporin A. SARS-CoV-2 [DOI] 10.13345/j.cjb.200049 PMC 바로가기 [Article Type] Review
Inhibition of cyclophilin A suppresses H 2 O 2 ‐enhanced replication of HCMV through the p38 MAPK signaling pathwayResearch Article Published on 2016-08-152023-08-30 Journal: FEBS Open Bio [Category] E형 간염, [키워드] cyclophilin A cytomegalovirus H2O2 p38 MAPK viral replication [DOI] 10.1002/2211-5463.12105 PMC 바로가기 [Article Type] Research Article
Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including AlisporivirArticle Published on 2014-02-222022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] alisporivir ALV, Alisporivir Caco-2 cell Cell culture cellular Concentration coronavirus Coronavirus replication CoV CoV infection CoV replication CsA/CsD, cyclosporine A/D cyclophilin cyclophilin A Cyclosporine/FK506-non-immunosuppressive derivatives CypA/B, cyclophilin A/B derivative EC50, 50% effective inhibitory concentration effective drug FK506 FKBP FKBP, FK506-binding protein growth HCoV-229E HCoV-NL63 Host Human human coronavirus Infection inhibit inhibited Inhibition of viral replication inhibitors magnitude New NIM811 NL63 PPIase, peptidyl prolyl cis/trans isomerase Prevent qPCR analysis Replication required SARS-CoV shown therapeutic approaches therapy virus replication Weber [DOI] 10.1016/j.virusres.2014.02.010 PMC 바로가기 [Article Type] Article