Targeting Viral and Cellular Cysteine Proteases for Treatment of New Variants of SARS-CoV-2Article Published on 2024-02-222024-09-05 Journal: Viruses [Category] update2024, [키워드] cysteine protease pseudovirus technology SARS-CoV-2 [DOI] 10.3390/v16030338 PMC 바로가기 [Article Type] Article
Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium bergheiArticle Published on 2023-11-012024-08-29 Journal: Cellular and Molecular Life Sciences [Category] 말라리아, [키워드] Apicoplast ATG4 autophagy cysteine protease Deconjugation EEF malaria Otu Plasmodium Sporozoites
Discovery of the Cryptic Sites of SARS-CoV-2 Papain-like Protease and Analysis of Its DruggabilityArticle Published on 2022-09-242022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, 치료제, [키워드] activated active sites binding pocket binding site caused changes in conformational change CoV COVID-19 COVID-19 pandemic cryptic pocket cysteine protease develop drug druggability drugs help induce inhibitor inhibitors MixMD New coronavirus outbreak pandemic Pathogenesis patients physicochemical property PLPro predict probe Probeview promote Protein Research residue Respiratory disease resulting SARS-CoV-2 SARS-CoV-2 PLpro Schrodinger Site solvent target protein TRAPP treat virus was used [DOI] 10.3390/ijms231911265 PMC 바로가기
Fluorine Atoms on C6H5-Corrole Affect the Interaction with Mpro and PLpro Proteases of SARS-CoV-2: Molecular Docking and 2D-QSAR ApproachesArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] 2D-QSAR 3CL pro acute respiratory syndrome binding binding affinity Compound compounds coronavirus correlation corroles cysteine protease decrease derivative docking score evaluated fluorine in silico in vitro In vitro assay increase in indicated inhibitor insertions Interaction M pro molecular docking MPro NMR nuclear Papain-like protease parameter physical-chemical PLPro protease Quantitative Region SARS-CoV-2 SARS-CoV-2 replication separated target the binding affinity two-dimensional was obtained [DOI] 10.3390/ijms231810936 PMC 바로가기
Calpains in cyanobacteria and the origin of calpains Research Published on 2022-08-162022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Anabaena analyses Analysis archaeal Bacteria Bacterial calpain cellular processes cleavage Clusters cysteine protease defined domain Donor enzyme eukaryote eukaryotes eukaryotic explain Human in silico independent information Interaction interaction partner investigated involved mammals Modification Phylogenetic analysis predicted Protein responsible retained selected substrates variety [DOI] 10.1038/s41598-022-18228-2 [Article Type] Research
Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes블루베리 잎과 줄기의 PAC(고중합 프로안토시아니딘) 성분은 ACE2 및 바이러스 3CLpro 효소의 억제를 통해 SARS-CoV-2 감염을 크게 억제합니다.Article Published on 2022-07-302022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 angiotensin Angiotensin II Angiotensin II converting Enzyme antiviral activity Antiviral effect Blueberry component COVID-19 cysteine cysteine protease develop effective enzyme examined extension fraction HCV hepatitis C hepatitis C virus highest HTLV-1 Infection inhibit SARS-CoV-2 inhibited inhibitory effect Inhibitory effects leukemia neutralization neutralization test no effect polymerization polymerized proanthocyanidin Proanthocyanidins pseudotyped SARS-CoV-2 reported SARS-CoV-2 SARS-COV-2 infection significantly Treatment Vaccinium Viral chymotrypsin-like cysteine protease (3CLpro). virus worldwide pandemic [DOI] 10.1016/j.bbrc.2022.04.072 PMC 바로가기 [Article Type] Article
Hydroxamate and thiosemicarbazone: Two highly promising scaffolds for the development of SARS-CoV-2 antivirals하이드록사메이트 및 티오세미카바존: SARS-CoV-2 항바이러스제 개발을 위한 2개의 매우 유망한 스캐폴드Article Published on 2022-07-012022-09-11 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome coronavirus Antiviral antiviral drugs ASN142 binding carbon competitive inhibitor coronavirus 2 COVID-19 COVID-19 pandemic Cys145 cysteine cysteine protease cytotoxicity development Dilution Docking studies docking study DTT effective inhibitor exhibited fibroblast cell H-bond H-bonds Health Hydroxamates hydroxyl inhibitor M pro main protease oxygen protease provided respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stability target thioester Thiosemicarbazones. viral duplication [DOI] 10.1016/j.bioorg.2022.105799 PMC 바로가기 [Article Type] Article
Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system원핵생물 발현 시스템에서 기능적으로 활성인 재조합 SARS-CoV-2(COVID-19) 3C 유사 프로테아제 및 가용성 불활성 3C 유사 프로테아제-RBD 키메라의 생산Article Published on 2022-06-202022-09-11 Journal: Epidemiology and Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] 3C-like protease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antigenicity approach blocked carrier cells Chimer chimeric chymotrypsin co-expressed complex coronavirus COVID-19 COVID-19 vaccines cysteine cysteine protease cysteine proteases dimeric disease drug ELISAs enzyme Escherichia coli Escherichia coli BL21 exhibit expression function inactive inhibitors inhibitory main protease non-structural protein non-structural proteins Papain Papain-like protease PLPro polyproteins pp1a pp1ab processing produced Production prokaryotic expression system protease Proteases Protein purification RBD Receptor binding domain RTC SARS-CoV-2 Serine serum severe acute respiratory syndrome Coronavirus solubility Spike protein target tested the Spike Transcription vaccinated individual vaccinated individuals viral replication [DOI] 10.1017/S0950268822001078 PMC 바로가기 [Article Type] Article
The Shigella Spp. Type III Effector Protein OspB Is a Cysteine Protease시겔라 Spp. III형 효과 단백질 OspB는 시스테인 프로테아제입니다.Article Published on 2022-05-312024-07-30 Journal: mBio [Category] 세균성이질, [키워드] catalytic dyad cysteine protease inositol hexakisphosphate OspB Shigella Tco89p TORC1 [DOI] 10.1128/mbio.01270-22 PMC 바로가기
Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategyResearch article Published on 2022-05-172022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, 치료법, 치료제, [키워드] activate acute respiratory syndrome antibiotic applied approach binding can be used cathepsin cathepsin L cleave clinically coronavirus coronavirus disease COVID-19 CTSL cysteine protease Daptomycin deep learning drug Drug discovery drug prediction enzyme expand FDA-approved drug identify Infection inhibit inhibit SARS-CoV-2 inhibitor inhibitory effect live SARS-CoV-2 molecular docking novel molecule other disease Potential predict pseudotype pseudovirus infection robust SARS-CoV-2 significantly small molecule Spike protein suggested therapeutic target these compound Treatment Z-FA-FMK [DOI] 10.1016/j.csbj.2022.05.023 [Article Type] Research article