Development of 2-chloroquinoline based heterocyclic frameworks as dual inhibitors of SARS-CoV-2 M Pro and PL ProArticle Published on 2023-05-112024-09-05 Journal: International journal of biological macromolecules [Category] update2024, [키워드] Antiviral cysteine proteases dual inhibitor Imine MPro PLpro quinoline SARS-CoV-2 [DOI] 10.1016/j.ijbiomac.2023.124772 PMC 바로가기 [Article Type] Article
Structural investigations of proteins encoded by SARS-CoV-2Article Published on 2022-09-012022-11-16 Journal: FEBS Open Bio [Category] SARS, 변종, 유전자 메커니즘, [키워드] antibodies articles bases categories cellular cleaved commenced coronavirus COVID COVID-19 pandemic cysteine proteases described ENCODE Evolution example expressed Final Genome include knowledge MN908947.3 molecular mechanism other coronaviruses pandemic polyprotein positive-sense Protein protein structure purified reported Research ribonuclease RNA genome RNAs SARS-CoV-2 selected sequenced single-stranded small molecule drugs Spike protein structural property the disease the spike protein translation Vaccines variant viral transcript were expressed [DOI] 10.1002/2211-5463.13465 PMC 바로가기
Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system원핵생물 발현 시스템에서 기능적으로 활성인 재조합 SARS-CoV-2(COVID-19) 3C 유사 프로테아제 및 가용성 불활성 3C 유사 프로테아제-RBD 키메라의 생산Article Published on 2022-06-202022-09-11 Journal: Epidemiology and Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] 3C-like protease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antigenicity approach blocked carrier cells Chimer chimeric chymotrypsin co-expressed complex coronavirus COVID-19 COVID-19 vaccines cysteine cysteine protease cysteine proteases dimeric disease drug ELISAs enzyme Escherichia coli Escherichia coli BL21 exhibit expression function inactive inhibitors inhibitory main protease non-structural protein non-structural proteins Papain Papain-like protease PLPro polyproteins pp1a pp1ab processing produced Production prokaryotic expression system protease Proteases Protein purification RBD Receptor binding domain RTC SARS-CoV-2 Serine serum severe acute respiratory syndrome Coronavirus solubility Spike protein target tested the Spike Transcription vaccinated individual vaccinated individuals viral replication [DOI] 10.1017/S0950268822001078 PMC 바로가기 [Article Type] Article
Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine페니실린 유도체는 친핵성 시스테인과 반응하여 SARS-CoV-2 주요 프로테아제를 억제합니다Article Published on 2022-06-092022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] analyses Analysis Bacterial Clinical efficacy complex COVID-19 COVID-19 treatment crystallographic analyses cysteine cysteine proteases derivative Enzymes highlight inhibitor inhibitors M pro mass spectrometric mechanism nucleophilic penicillin protease reaction SARS-CoV-2 main protease Serine shown synthesis the SARS-CoV-2 Treatment [DOI] 10.1021/acs.jmedchem.1c02214 PMC 바로가기 [Article Type] Article
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity결합 협동성을 활용하는 COVID-19 항바이러스 치료를 위한 SARS-CoV-2 PLpro 억제제의 설계Article Published on 2022-02-242022-09-11 Journal: Journal of medicinal chemistry [Category] 치료제, [키워드] antiviral agent Antiviral agents antiviral potency binding binding affinities binding interaction binding site complement cooperativity COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases glycine Host host protein human cells immune sensing induce inhibitor inhibitory potency Interaction Ligand mimicking New novel overcome Papain-like protease PLPro recognizing regulate reported SARS-CoV-2 Structure substrates therapeutic target translate ubiquitin vaccination viral replication yielding [DOI] 10.1021/acs.jmedchem.1c01307 PMC 바로가기 [Article Type] Article
Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/LResearch Article Published on 2021-08-182022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] activate analyzed cathepsin Combination Compound COVID-19 CTSL cysteine proteases drug drug combination Effect enrichment analysis entry pathway expression gene expression signature gene-gene interaction Genes GSEA host cells host protease human proteins identify interact molecular docking analysis performed potential treatment option Proteases regulatory element SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 proteins serine protease target the spike protein Therapeutic benefit therapy TMPRSS2 transmembrane serine protease upstream [DOI] 10.1371/journal.pone.0256141 PMC 바로가기 [Article Type] Research Article
Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar luteaArticle Published on 2021-08-052022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] Nuphar 6,6′-dihydroxythiobinupharidine binding binding site biochemical catalytic cathepsin complexes condition covalent docking COVID-19 cysteine cysteine protease cysteine proteases demonstrated derivative determine disulfide bond docking docking results electrophilic inactive inhibition inhibitors Interaction lack M pro MPro mechanism molecular molecular dynamic simulation nucleophilic Nuphar performed reactivity SARS-CoV-2 shown specificity stability suggested supported tested [DOI] 10.3390/molecules26164743 PMC 바로가기 [Article Type] Article
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19COVID-19에 대한 치료 전략으로 SARS-CoV-2 프로테아제를 표적화하기 위한 과제Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] MERS, SARS, 진단, 치료제, [키워드] antiviral potency cathepsin cathepsin cross-reactivity Cathepsins Cell cellular challenge Compound COVID-19 cysteine cysteine protease cysteine proteases determine effective inhibitor effort evaluated explained expressing expression focus highlight host cell identify infection assays inhibited inhibitor inhibitors lead lysosomal cathepsins M pro main protease Papain Papain-like protease potency Prevent produced protease Proteases purified reported SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 virus screened selectivity Serine Strategy targeting the SARS-CoV-2 virus TMPRSS2 transmembrane serine protease Treatment treatment of COVID-19 Viral viral entry viral entry pathway viral infectivity viral replication [DOI] 10.1021/acsinfecdis.0c00815 PMC 바로가기 [Article Type] Article
Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain DeubiquitinasesArticle Published on 2021-05-282022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] approach binding catalytic compounds coronavirus covalent docking crystal structures cysteine protease cysteine proteases cysteine residue deubiquitinase docking drug design DUB Dynamics effective drug indicate inhibitor Interaction interactions knowledge Ligand ligand-bound modeling molecular dynamics OTUB1 OTUB2 pandemic Papain-like protease parameter PLPro protease protocol reactivity Research SARS-CoV SARS-CoV-2 selective stability stimulated subsequent suppress the SARS-CoV-2 Tumor viral replication were used [DOI] 10.3390/biom11060802 PMC 바로가기 [Article Type] Article
Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like ProteaseSARS 코로나바이러스 2 파파인 유사 프로테아제에 대한 새로운 억제 스캐폴드를 추구하기 위해 인실리코 파이프라인 기반 유사체 구축Article Published on 2021-02-202022-09-10 Journal: Molecules [Category] MERS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogue analogues approved AutoDock AutoDock tools binding affinities binding affinity caused comparable Compound conducted Consequences coronavirus COVID-19 crystal structure cysteine cysteine proteases docked docking drug Drug discovery drug-likeness electrostatic Enamine Establishing fatality feature identify in silico in vitro inhibit inhibitor inhibitors Interaction knowledge lack Ligand M pro molecular docking novel outbreak pandemic Papain Papain-like protease performed PLpro predicted profiles protease protein-ligand interaction Region Replication respiratory SAR SARS coronavirus 2 SARS coronaviruses SARS-CoV-1 SARS-CoV-2 scaffold hopping severe acute respiratory syndrome Coronavirus similarity targets Viral viral replication Virtual screening [DOI] 10.3390/molecules26041134 PMC 바로가기 [Article Type] Article