On the Recognition of Natural Substrate CTP and Endogenous Inhibitor ddhCTP of SARS-CoV-2 RNA-Dependent RNA Polymerase: A Molecular Dynamics StudyArticle Published on 2022-10-242022-11-15 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 치료제, [키워드] absence affecting Antiviral computational method COVID-19 outbreak Cryo-electron microscopy cytidine Dynamics endogenous enzyme help implication in silico information inhibitor inhibitory innate immune response investigated MD simulation mechanism molecular molecular mechanism multiple mutation natural novel coronavirus SARS-CoV-2 nucleotide pandemic Protein RdRP RdRp active site Recognition responsible RNA RNA sequence RNA-dependent RNA polymerase SARS-CoV-2 substrate viral replication virus [DOI] 10.1021/acs.jcim.2c01002 PMC 바로가기
ORAL NEUROPATHIC PAIN POST-COVID-19 IN A YOUNG BRAZILIAN PATIENTConference abstract Published on 2022-09-012022-10-05 Journal: Oral surgery, oral medicine, oral pathology and or [Category] 변종, [키워드] Anosmia complication of COVID-19 complications Concentration concerning cough COVID-19 cytidine develop disease fatigue information knowledge Medicine memory myalgia nasal congestion neurologic neuropathic neuropathic pain oral oral examination osseous Pain patients with COVID-19 positive presenting reported service sore throat Treatment uridine vitamin B12 worsening [DOI] 10.1016/j.oooo.2022.01.079 [Article Type] Conference abstract
Concise synthesis of antiviral drug, molnupiravir by direct coupling of fully protected d-Ribose with cytosineShort communication Published on 2022-05-012022-10-05 Journal: Tetrahedron Letters [Category] 치료제, [키워드] Anti-viral antiviral drug cytidine cytosine d-Ribose effective expand expected group groups hydrolysis hydroxy less molnupiravir Ribonucleoside uridine [DOI] 10.1016/j.tetlet.2022.153783 [Article Type] Short communication
Antiviral metabolite 3′-deoxy-3′,4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19항바이러스 대사 산물 3'-deoxy-3',4'-didehydro-cytidine은 혈청에서 검출 가능하며 COVID-19를 포함한 급성 바이러스 감염 식별Article Published on 2022-03-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI acute infection acute viral infection Admission an area Antiviral AUC Bacterial Bacterial infection Bacterial infections Biomarker characteristic CMPK2 Cohort correlated COVID-19 Critical cytidine ddhC detectable Diagnosis diagnostic diagnostics emergency department enzyme Enzymes examined FIVE Gene Expression healthy controls High-resolution highlight identify implicated in viral in vivo independent inflammatory conditions interferon Liquid chromatography management marker mass spectrometry metabolite metabolome metabolomics NIHR pandemic Patient precursor Profiling receiver operating characteristic receiver operating characteristic curve responsible sera serum significantly small molecule Support transcripts validation cohort viperin Viral viral infection viral infections [DOI] 10.1016/j.medj.2022.01.009 PMC 바로가기 [Article Type] Article
An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir코비드-19 항바이러스제 몰누피라비르의 핵심 중간체의 생체촉매 생산을 위한 조작된 시티딘 데아미나제Article Published on 2022-03-092022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral drug antiviral drugs approved benefit COVID-19 pandemic cytidine Cytidine deaminase Deaminase enzyme highlight intermediate less molnupiravir nucleoside pandemic Production SARS-CoV-2 selective Treatment [DOI] 10.1021/jacs.1c11048 PMC 바로가기 [Article Type] Article
Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered SynthesisReview article Published on 2021-12-092022-10-05 Journal: Organic Process Research & Development [Category] 치료제, [키워드] acetone antivirals approach average carried COVID-19 cytidine described EIDD-2801 HPLC isopropanol MK-4482 molnupiravir Process purification reagent solvent synthesis [DOI] 10.1021/acs.oprd.1c00219 [Article Type] Review article
Cytidine deamination-induced perpetual immunity to SAR-CoV-2 infection is a potential new therapeutic targetSAR-CoV-2 감염에 대한 시티딘 탈아미노화 유도 영구 면역은 잠재적인 새로운 치료 표적입니다Review Published on 2021-10-152022-09-10 Journal: International Journal of Medical Sciences [Category] MERS, SARS, 변종, [키워드] antibody Asymptomatic cause causes cell types contributing to COVID 19 COVID-19 cytidine Cytidine deaminase develop focus generate Human immune cell type immune cell types immune response immune responses immune system Immunity Infection initiate long-lasting molecular New variants of Coronavirus Perpetual immunity provided reason Research responses SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 virus SRS-CoV-2 Survivors symptomatic people the SARS-CoV-2 virus therapeutic target vaccination Variation variations viral strains virus [DOI] 10.7150/ijms.61779 PMC 바로가기 [Article Type] Review
[Plitidepsin, an inhibitor of the cell elongation factor eEF1a, and molnupiravir an analogue of the ribonucleoside cytidine, two new chemical compounds with intense activity against SARS-CoV-2][세포신장인자 eEF1a 억제제 플리티뎁신과 리보뉴클레오시드 시티딘 유사체 몰누피라비르, SARS-CoV-2에 대한 강력한 활성을 가진 두 가지 새로운 화합물]Review Published on 2021-10-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] SARS, 치료제, [키워드] Administered administration analogues animals Cell cellular Compound Culture cytidine decrease determine elongation factor English human cell human clinical trials inhibiting inhibitor Interaction intravenously knowledge lethal mutagenesis molnupiravir molnupiravir (MK-4482/EIDD-2801) Mutagenesis oral administration oropharynx phase Plitidepsin potency Prevent Prophylaxis Protein pulmonary viral Remdesivir replicative Ribonucleoside SARS-CoV-2 SARS-CoV-2 sntiviral Spanish therapeutic Transmission virus [DOI] 10.37201/req/042.2021 PMC 바로가기 [Article Type] Review
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis몰누피라비르 유발 SARS-CoV-2 돌연변이 유발 메커니즘Article Published on 2021-08-112022-09-10 Journal: Nature Structural & Molecular Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] (RdRp (RdRp) active form Analysis animal model animal models antiviral activity antiviral drug base pair base pairs biochemical assay cause complexes COVID-19 Cryo-EM analysis Cryoelectron microscopy cytidine cytidine triphosphate explain Frequency High-resolution humans impair incorporation increase mechanism molecular mechanism molecular mechanisms molnupiravir Mutagenesis mutated Mutation NHC patients with COVID-19 phase III trial Phase III trials polymerase Proofreading RdRP resulting RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 mutagenesis SARS-CoV-2 replication Structural analysis substrate Template Treatment triphosphate uridine uridine triphosphate Viral Viral mutagenesis Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1038/s41594-021-00651-0 PMC 바로가기 [Article Type] Article
Putative Repurposing of Lamivudine, a Nucleoside/Nucleotide Analogue and Antiretroviral to Improve the Outcome of Cancer and COVID-19 PatientsOncology Published on 2021-07-212022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] 3TC addition analogue anti-SARS-CoV-2 anticancer antiretroviral Antiretrovirals Antiviral Cancer cancer cell carried Cell Chemotherapy Combination COVID-19 COVID-19 pandemic cytidine cytosine docking Effect Effectiveness evaluate Evidence HBV HBV infection hepatitis B HIV HIV positive HIV-1 infection in silico indicated Inflammation inhibit inhibitor lamivudine life-threatening liver Patient patients positive Prevent Radiotherapy RdRP RdRp RNA polymerase receive repurposing RNA polymerase SARS-CoV-2 shown Side effect the SARS-CoV-2 tissues Treatment viral replication virus virus infection [DOI] 10.3389/fonc.2021.664794 PMC 바로가기 [Article Type] Oncology