Differences in Treatment Patterns and Patient Characteristics Between COVID-19 Patients Treated with Nirmatrelvir/Ritonavir and Ensitrelvir in JapanShort Report Published on 2024-08-202024-09-05 Journal: International Journal of General Medicine [Category] update2024, [키워드] 3C-like protease cytochrome P450 Guidance SARS-CoV-2 [DOI] 10.2147/IJGM.S475833 PMC 바로가기 [Article Type] Short Report
Rapid detection of Mycobacterium tuberculosis based on cyp141 via real-time fluorescence loop-mediated isothermal amplification (cyp141-RealAmp)article Published on 2024-06-132024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] cytochrome P450 LAMP Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis complex Tuberculosis Xpert MTB/RIF ; cyp141-RealAmp [DOI] 10.3389/fcimb.2024.1349063 PMC 바로가기 [Article Type] article
Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translationResearch Paper Published on 2023-06-162024-09-05 Journal: Redox Biology [Category] update2024, [키워드] bronchopulmonary dysplasia CYP1B1 cytochrome P450 hyperoxia lung oxidative stress [DOI] 10.1016/j.redox.2023.102790 PMC 바로가기 [Article Type] Research Paper
Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria ImmunosuppressionArticle Published on 2023-06-162024-08-29 Journal: International Journal of Molecular Sciences [Category] 말라리아, [키워드] 4-hydroxynonenal 4-HNE CYP4F11 cytochrome P450 human monocytes hydroxyeicosatetraenoic acids HETEs lipoperoxidation malaria
Resilience of transfluthrin to oxidative attack by duplicated CYP6P9 variants known to confer pyrethroid resistance in the major malaria mosquito Anopheles funestusarticle Published on 2023-04-302024-09-01 Journal: Hospitals [Category] 말라리아, [키워드] Anopheles CYP6P9a CYP6P9b cytochrome P450 Pyrethroids Transfluthrin [Article Type] article
A cocktail probe approach to evaluate the effect of hormones on the expression and activity of CYP enzymes in human hepatocytes with conditions simulating late stage of pregnancyResearch Published on 2023-04-152024-09-05 Journal: European Journal of Clinical Pharmacology [Category] update2024, [키워드] Cocktail probes cytochrome P450 female hormones Liquid chromatography-tandem mass spectrometry (LC–MS/MS) Pregnancy primary human hepatocytes Quantitative real-time polymerase chain reaction (qRT-PCR) [DOI] 10.1007/s00228-023-03489-1 PMC 바로가기 [Article Type] Research
Sequential phase I metabolism of pyrethroids by duplicated CYP6P9 variants results in the loss of the terminal benzene moiety and determines resistance in the malaria mosquito Anopheles funestusarticle Published on 2022-09-302024-09-01 Journal: Insect Biochemistry and Molecular Biology [Category] 말라리아, [키워드] Anopheles cytochrome P450 insecticide pyrethroid resistance vector control [Article Type] article
New Perspectives on Antimicrobial Agents: Molnupiravir and Nirmatrelvir/Ritonavir for Treatment of COVID-19항균제에 대한 새로운 관점: 코로나19 치료를 위한 몰누피라비르 및 니르마트렐비르/리토나비르Article Published on 2022-08-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted relative risk antimicrobial Antiviral cause childbearing potential children Complication Contraception coronavirus disease Coronavirus-2 COVID-19 cytochrome P450 Cytochrome P450 enzymes death drug Drug administration Drug-to-drug interaction Each Emergency use authorization food hospitalizations in vitro inhibit limit management medication metabolism Mild mild to moderate moderate molnupiravir morbidity and mortality Mutation New Nirmatrelvir Nirmatrelvir/ritonavir nonspecific outcome pandemic Patient polymerase polyprotein pregnant protease proteolytic cleavage reduction Relative risk Replication Respiratory disease risk Ritonavir SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly target tested Toxicity Treatment treatment regimen U.S. Food and Drug Administration variant viral replication virus virus production [DOI] 10.1128/aac.02404-21 PMC 바로가기 [Article Type] Article
Benzo[ a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity벤조[a]피렌-환경 발생, 인체 노출 및 독성 메커니즘Review Published on 2022-06-062022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] aromatic hydrocarbon association benzo[a]pyrene carcinogenic carcinogenicity cause cigarette smoke concerning COVID-19 pandemic cytochrome P450 determine DNA epoxy Evidence exhibit exposure exposure to expressed facilitate genotoxicity Human impairment involved mechanism metabolism multiplication Mutation neurotoxic Occurrence organism P450 polycyclic polycyclic aromatic hydrocarbons. polymorphism pyrene receptor sensitivity Soil Surface water teratogenic toxic effect toxic effects Toxicity turn viruses water widespread xenobiotics [DOI] 10.3390/ijms23116348 PMC 바로가기 [Article Type] Review
Physiologically-Based Pharmacokinetic-Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor-Tezacaftor-Ivacaftor With Nirmatrelvir-Ritonavir for the Treatment of COVID-19낭포성 섬유증 환자를 위한 생리학적 기반 약동학 주도 지침Article Published on 2022-06-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] 변종, [키워드] Administered approach AUC CFTR Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cystic cystic fibrosis cytochrome P450 Day decrease dose drug interaction drug-drug interaction elexacaftor eliminated evaluated fibrosis independent information inhibited inhibiting inhibitor inhibitory effect ivacaftor metabolism modeling modulating Nirmatrelvir P450 parameter pharmacokinetic pharmacokinetics physiological predict predicted reduced regimen risk Ritonavir Simulation Taking tezacaftor therapeutic Therapies transmembrane Treatment was performed [DOI] 10.1002/cpt.2585 PMC 바로가기 [Article Type] Article