The role of P450 enzymes in malaria and other vector-borne infectious diseasesArticle Published on 2024-02-282024-09-09 Journal: Biofactors [Category] 말라리아, [키워드] Cytochrome P450 enzymes Insecticide resistance malaria vector-born infection diseases. PMC 바로가기
Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19Review article Published on 2022-10-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 acute respiratory syndrome alteration angiotensin-converting enzyme 2 Biomarker caused changes in Coagulation coagulation cascade coagulation factor Coagulation parameters Coagulopathy coronavirus Coronaviruses COVID-19 Cytochrome P450 enzymes cytokine Effect elevated Endothelial dysfunction enzyme In-hospital Infection Inflammation involved mechanism melatonin Mortality outcomes Patient Platelet Prophylactic RAS regulate reported risk factor SARS-CoV-2 SARS-COV-2 infection secreted severity Stress suggested the cytokine storm [DOI] 10.1016/j.lfs.2022.120866 [Article Type] Review article
New Perspectives on Antimicrobial Agents: Molnupiravir and Nirmatrelvir/Ritonavir for Treatment of COVID-19항균제에 대한 새로운 관점: 코로나19 치료를 위한 몰누피라비르 및 니르마트렐비르/리토나비르Article Published on 2022-08-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted relative risk antimicrobial Antiviral cause childbearing potential children Complication Contraception coronavirus disease Coronavirus-2 COVID-19 cytochrome P450 Cytochrome P450 enzymes death drug Drug administration Drug-to-drug interaction Each Emergency use authorization food hospitalizations in vitro inhibit limit management medication metabolism Mild mild to moderate moderate molnupiravir morbidity and mortality Mutation New Nirmatrelvir Nirmatrelvir/ritonavir nonspecific outcome pandemic Patient polymerase polyprotein pregnant protease proteolytic cleavage reduction Relative risk Replication Respiratory disease risk Ritonavir SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly target tested Toxicity Treatment treatment regimen U.S. Food and Drug Administration variant viral replication virus virus production [DOI] 10.1128/aac.02404-21 PMC 바로가기 [Article Type] Article
Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target ProteinsSARS-CoV-2 표적 단백질에 대한 전통적인 식물의 일부 생리 활성 화합물의 도킹 분석Article Published on 2022-04-202022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption binding affinity binding energy binding site bioactive compounds caffeic acid Cepharanthine Chimera Compound COVID-19 COVID-19 patients Curcumin cytochrome P450 Cytochrome P450 enzymes demonstrated docked drug-likeness exhibited Express expressed flavin global pandemic inhibited inhibiting inhibitor inhibitors inhibitory effect introduced Ligand ligands Medicine molecular molecular docking Multidrug resistance Papain Papain-like protease pharmacokinetic plant plants PLPro predicted prediction protease Protein protocol Quinine RdRP required Research Result RNA RNA dependent RNA polymerase RNA polymerase rule S-protein SARS-CoV-2 Spike protein suggested target target protein target proteins tested the disease theaflavin these compound these compounds Traditional traditional plants. treating COVID-19 patient Treatment viral spike protein Withaferin A [DOI] 10.3390/molecules27092662 PMC 바로가기 [Article Type] Article
Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapyQingfei Paidu 달인에 의한 약물 대사 효소 억제: COVID-19 약물 요법에서 허브-약물 상호 작용의 의미Article Published on 2021-03-012022-08-31 Journal: Food and chemical toxicology : an international jo [Category] SARS, 치료제, [키워드] AUC caused China Chinese clinical settings clinically clinician combating Combination concomitant use Corona COVID-19 COVID-19 treatment CYP3A substrate-drugs cytochrome P450 Cytochrome P450 enzymes Cytochrome P450 enzymes (CYPs/P450s) demonstrated Effect enzyme half-life Health Herb Herb-drug interactions (HDIs) in vivo inactivated inhibited inhibition inhibitory Interaction interactions Lopinavir medication modulated NADPH P450s pharmacokinetic pharmacokinetics Qingfei Paidu decoction (QPD). RATs risk significantly Spread the patient Treatment Trigger Virus Disease [DOI] 10.1016/j.fct.2021.111998 PMC 바로가기 [Article Type] Article