cytokine expression – Communicable Diseases Research

Distinct immune responses in the early phase to natural SARS-CoV-2 infection or vaccination

Article

Published on 2022-12-012022-11-15
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단,

Immunogenicity of candidate SARS-CoV-2 DNA vaccines based on the spike protein

스파이크 단백질을 기반으로 한 후보 SARS-CoV-2 DNA 백신의 면역원성

Article

Published on 2022-08-012022-09-12
Journal: Virology [Category] COVID19(2023년), MERS, SARS, 진단,

Acute Surge of Atypical Memory and Plasma B-Cell Subsets Driven by an Extrafollicular Response in Severe COVID-19

심각한 COVID-19에서 난포 외 반응에 의해 구동되는 비정형 기억 및 혈장 B-세포 하위 집합의 급성 급증

Article

Published on 2022-07-082022-09-12
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, 진단,

[키워드] accumulating acute phase acute respiratory syndrome addition anti-SARS-CoV-2 antibody Antibody Response Atypical B cell B cells B-cell B-cell response BCR Cell Clinical severity coronavirus coronavirus disease COVID-19 COVID-19 patient Critical cytokine expression dataset disease course Disease progression disease severity driven by driver elevated Evidence extrafollicular response feature Features groups heterogeneous humoral Humoral immunity Inflammatory investigated mechanism memory B cell moderate naïve pandemic pathogenic pathway PC2 Peripheral blood plasma Plasma cell Plasma cells progression public health receptor response RNA robust Sequencing analysis severe COVID-19 severe COVID-19 patients severe disease severe patients severity single-cell subset Trajectory analysis transcriptional Vaccine with COVID-19
[DOI] 10.3389/fcimb.2022.909218 PMC 바로가기 [Article Type] Article

Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro

기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다

Article

Published on 2022-06-282022-09-11
Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used
[DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article

T-Cell Defects Associated to Lack of Spike-Specific Antibodies after BNT162b2 Full Immunization Followed by a Booster Dose in Patients with Common Variable Immune Deficiencies

공통 가변 면역 결핍증 환자에서 BNT162b2 완전 면역 후 추가 용량 투여 후 스파이크 특이적 항체의 결핍과 관련된 T-세포 결함

Article

Published on 2022-06-142022-09-12
Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] abnormality absence anti-SARS-CoV-2 IgG antibody Antibody Response Autoimmune Autoimmunity BNT162b2 booster booster dose CD40L CD8+ central memory circulating common Common variable immune deficiencies complex contributed COVID-19 CVID cytokine expression defect did not produce disease phenotype dose evaluated expressing expression followed by Frequency healthy donor IFNγ IgA IgA antibodies IgG immunization lung damage lymphocyte counts memory B memory B cells mRNA vaccine naïve of BNT162b2 Patient peptides Peripheral blood Responder SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibody specific antibody spike Spike protein T cell T-cell T-cells T-cells response Testing the patient TNFα Vaccine vaccine dose variable virus spike protein was performed
[DOI] 10.3390/cells11121918 PMC 바로가기 [Article Type] Article

Case Report: Evolution of Humoral and Cellular Immunity in Two COVID-19 Breakthrough Infections After BNT162b2 Vaccine

사례 보고서: BNT162b2 백신 후 2건의 COVID-19 돌발 감염에서 체액 및 세포 면역의 진화

Case Reports

Published on 2022-02-232022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function

Clinical Medicine

Published on 2022-02-222022-10-30
Journal: JCI Insight [Category] COVID-19, COVID19(2023년), SARS,

[키워드] Acetate adaptive Adaptive immunity Affect anti-CD20 antibody Autoimmunity B cell CD19 CD4 CD8 cellular immunity characterized Clinical guidelines Cohort correlated COVID-19 cumulative cytokine expression Effect epitope foundation fumarate functional groups healthy control humoral IgG level Immunity Immunotherapy implication large cohort Luminex assay mAbs marker Multiple multiple sclerosis neutralization NIH participant Patient patients pseudovirus Quantitative reactivity receiving receptor reduced remained response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination spike Study participants T cell T cell response T cell responses therapy treated Treatment were assessed were measured
[DOI] 10.1172/jci.insight.156978 PMC 바로가기 [Article Type] Clinical Medicine

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS

Immunology

Published on 2021-11-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Relative expression of proinflammatory molecules in COVID-19 patients who manifested disease severities

질병 중증도를 나타내는 COVID-19 환자에서 전염증 분자의 상대적 발현

Article

Published on 2021-10-012022-09-11
Journal: Journal of medical virology [Category] SARS, 치료기술, 치료제,

[키워드] ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus 2 Aggressive angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Chain Reaction characterized chemokine chemokines convalescent stage coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine expression Cytokines Day diagnosed disease disease severities disease severity expressed expression expression level expression levels expressions female patient Female patients groups healthy volunteer help IL-12 IL-6 immune response immune system immune systems Inflammatory interleukin investigated leukocyte leukocytes log Macrophage management manifested Mild moderate monocyte monocyte chemotactic protein-1 nasal swab Necrosis nine onset of symptom opposite overexpressed participated Patient patients PCR method performed polymerase chain polymerase chain reaction positive correlation positively correlated post-COVID-19 patient proinflammatory proinflammatory molecule proinflammatory molecules Quantitative RANTES real-time RT-PCR regulated relative relative expression relative expression. RNA secreted semi-quantified severe acute respiratory syndrome Coronavirus severe cases significantly SPSS SPSS 24.0 statistical test Statistical tests T cell the patient therapy TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α upregulated Viral load
[DOI] 10.1002/jmv.27112 PMC 바로가기 [Article Type] Article

The Cross-Talk between Thrombosis and Inflammatory Storm in Acute and Long-COVID-19: Therapeutic Targets and Clinical Cases

Case Report

Published on 2021-09-232022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] activate Activation acute phase acute respiratory syndrome addition Adhesion Molecule administration adopted alteration anti-inflammatory properties Anticoagulant anticoagulant therapy Anticoagulants blood chemistry cardiovascular risk Cell characterized circulating clinical clinical expression Coagulation coagulation cascade Coagulation factors coagulation parameter Coagulopathy complicate component Coronavirus-2 COVID-19 COVID-19 patient COVID-19 patients criteria cross-talk cytokine cytokine expression Cytokines death rate Disseminated intravascular coagulation DOAC DOACs Efficacy endothelial damage evaluate factor Xa Growth factors IMPROVE Inflammation Inflammatory inhibit leucocyte LMWH Local long-COVID-19 oral anticoagulant outcomes PARs Patient patients persistence PF4 Platelet promote inflammation prothrombotic state receptor SARS-CoV-2 storm suggested Survivors Symptom syndrome target thrombin Treatment Venous Thromboembolism VTE
[DOI] 10.3390/v13101904 PMC 바로가기 [Article Type] Case Report