SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 OutcomeCovid-19 결과의 예측에서 SCD14-ST 및 신세대 염증 바이오 마커Article Published on 2022-06-132022-08-31 Journal: Biomolecules [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] addition Biomarker Biomarkers canonical clinical feature Clinical features COVID-19 COVID-19 mortality COVID-19 positive patients CRP cytokine Cytokine storm Cytokines cytokines IL-6 died discharged disease Generation ICU ICU Patients IL-10 IL-6 immune immune biomarkers Infection inflammatory biomarkers Inflammatory marker inflammatory markers inflammatory parameters Laboratory Longitudinal evaluation longitudinal study New new infection outcome Patient plasma-EDTA predict prediction prediction of disease. prognostic SARS-CoV-2 SCD14-ST severity significantly higher suPAR the disease to define were measured [DOI] 10.3390/biom12060826 PMC 바로가기 [Article Type] Article
Elevated Anti-SARS-CoV-2 Antibodies and IL-6, IL-8, MIP-1β, Early Predictors of Severe COVID-19Article Published on 2021-10-292022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute COVID-19 acute infection anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies association baseline Concentration COVID-19 COVID-19 patient COVID-19 severity criteria Cytokines cytokines IL-6 Diagnosis disease eight hospitalized COVID-19 patient Host ICU IFN-γ IgA IgG IgG antibodies IgM IL-1β IL-6 IL-8 immune intensive care Laboratory male median age MIP-1α MIP-1β MOST outcome persistence predictor Proinflammatory cytokine SARS-CoV-2 SARS-CoV-2 RNA severe COVID-19 severe COVID-19 disease Symptom Viral load were measured [DOI] 10.3390/microorganisms9112259 PMC 바로가기 [Article Type] Article
Predicting the Severity of Disease Progression in COVID-19 at the Individual and Population Level: A Mathematical ModelArticle Published on 2021-07-312022-10-31 Journal: Clinical & experimental pharmacology [Category] COVID-19, [키워드] age Analysis Clinical outcome Comorbidities complex contribute Course COVID-19 COVID-19 disease COVID-19 pathology Cytokine-storm cytokines IL-6 develop disease Disease progression Factor Fever Health IFNα immune response immunological parameters individual individual level Inflammation Innate interferon lymphocyte lymphopenia magnitude manifested mathematical Model modeling neutralizing antibody Neutralizing-antibodies parameter Pathogenesis Population population level predict prediction provide resource SARS-CoV-2 infected individuals selected Severe case the cytokine storm Viral factors PMC 바로가기 [Article Type] Article
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitroResearch Article Published on 2021-06-162022-10-29 Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] Bacterial Bacterial sepsis Blood Bone marrow CD14 Cell cell subpopulation cells cellular clinical manifestation correlated COVID-19 CRISPR-Cas9 Culture cytokine cytokines IL-6 datasets demonstrated dysregulation expression Factor Gene Expression healthy IL-10 IL-6 immunosuppressive in vitro in vitro study induce monocyte MS1 myeloid myeloid cell neutrophil Patient plasma plasma concentration progenitor cell receptor reported RNA SARS-COV-2 infection Sepsis severe COVID-19 severe COVID-19 patient severe infections severity systemic cytokine transcriptomics Treatment up-regulated [DOI] 10.1126/scitranslmed.abe9599 PMC 바로가기 [Article Type] Research Article
The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent MannerArticle Published on 2021-06-032022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] ACE2 acute lung injury acute respiratory distress acute respiratory syndrome AKT ALI ARDS Betacoronavirus Calu-3 Cell characterized chemokine chemokines CXCL9 contribute contributing to coronavirus Coronavirus disease 2019 COVID-19 CXCL10 CXCL11 CXCL9 cytokine Cytokine storm cytokines IL-6 develop elevated enzyme epithelial cell feature Gene Expression GSK690693 hACE2 mice human lung hyperinflammation IFN-γ IL-6 immunostimulatory include increase in increases in infected with SARS-CoV-2 inflammatory state inhibitor kinase lung mechanical ventilation mice overexpression pandemic pathway positive individual pro-inflammatory pulmonary complication reduced reducing responsible RNA virus Sample SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 Signaling signaling pathway significantly small molecule inhibitor syndrome target TNFα transcript Transcription transgenic Treatment upregulation were used [DOI] 10.3390/v13061062 PMC 바로가기 [Article Type] Article
COVID-19 Impairs Immune Response to Candida albicansCOVID-19는 Candida albicans에 대한 면역 반응을 손상시킵니다Immunology Published on 2021-02-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] abrogated Activation acute respiratory distress acute respiratory distress syndrome Antigen ARDS Aspergillus fumigatus Blood Candida Candida albican Candida albicans CD244 CD38 CD4 CD8 CD80 changes in characterization characterized clinical parameter Clinical parameters coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients cytokine cytokine release Cytokines cytokines IL-6 detrimental elevated fungal healthy controls HLA-DR ICU ICU admission IL-10 IL-1α IL-1β IL-6 IL-8 Immune phenotype immune response Infection lipopolysaccharide Listeria monocytogene Listeria monocytogenes LPS Lymphocytes marker monocyte Monocyte activation not differ Pathogenesis PD-1 plasma Prognosis recent respiratory distress response SARS-CoV-2 second hit Secondary infection secondary infections severe acute respiratory distress syndrome susceptibility syndrome T cells therapy TNF upregulation were assessed were used yeast [DOI] 10.3389/fimmu.2021.640644 PMC 바로가기 [Article Type] Immunology