The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitnessArticle Published on 2022-09-132022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] anti-viral activity APOBEC APOBEC1 APOBEC3A APOBEC3G Caco-2 cell COVID-19 pandemic cytosine evade Evolution experimental evidence expression Factors genomic RNA Host inhibited Modification motif Mutation mutations new strain Patient progeny promote random Replication RNA SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2 sequence Vaccines viral genome wild-type [DOI] 10.1038/s41598-022-19067-x PMC 바로가기
Variation in synonymous nucleotide composition among genomes of sarbecoviruses and consequences for the origin of COVID-19사베코바이러스 게놈 간 동의 염기 조성의 변이와 코로나19의 기원에 대한 영향Article Published on 2022-08-152022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysed bat bat virus Bulgaria China Codons consequence coronavirus COVID-19 COVID-19 pandemic cytosine degenerate diagnosed dinucleotides distribution eight Evidence evidence of explain feature FIVE Genome genomes group horseshoe bat Host host cell host cells include independent intermediate intermediate host Japan Kenya less Manis javanica mutations nucleotide pangolin pangolins RdRP RdRp selection Recombination reservoir Reservoir host responsible sarbecovirus Sarbecoviruses SARS epidemic SARS-CoV SARS-CoV-2 subgenus synonymous synonymous mutations the SARS epidemic uracil viral replication viruses [DOI] 10.1016/j.gene.2022.146641 PMC 바로가기 [Article Type] Article
The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repressionNSP1 매개 억제의 바이러스 탈출에 필요한 SARS-CoV-2 리더 및 NSP1의 주요 기능Article Published on 2022-05-012022-09-11 Journal: RNA (New York, N.Y.) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis Antiviral ASO binding blockade carried cellular mechanisms cellular mRNA cellular mRNAs component components cytosine Defense down-regulate early stage ENhance expresse expression feature functional global pandemic help Host host gene host genes Infection inhibit interfere mechanism mRNA mRNAs nonstructural protein 1 nsp1 overcome Pathways Replication required residue responsible ribosome SARS-CoV-2 Spread targets the SARS-CoV-2 translation translational repression translational repression. viral escape viral mRNAs Viral RNA virus viruses [DOI] 10.1261/rna.079086.121 PMC 바로가기 [Article Type] Article
Concise synthesis of antiviral drug, molnupiravir by direct coupling of fully protected d-Ribose with cytosineShort communication Published on 2022-05-012022-10-05 Journal: Tetrahedron Letters [Category] 치료제, [키워드] Anti-viral antiviral drug cytidine cytosine d-Ribose effective expand expected group groups hydrolysis hydroxy less molnupiravir Ribonucleoside uridine [DOI] 10.1016/j.tetlet.2022.153783 [Article Type] Short communication
Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: an in silico structure-based approach승인 및 연구 약물과 SARS-CoV-2 Nsp12/Nsp8 상호 작용 인터페이스 표적화: in silico 구조 기반 접근Article Published on 2022-02-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] analysed Analysis approach approved binding binding pocket complex complexes Compound computer-aided drug design conserved COVID-19 cytosine drug drug repositioning enzyme Enzymes highest binding affinity in silico in viral in vivo inhibitors Interaction interruption isolate Ligand MD simulation mutant Mutation mutation analysis mutations Nebivolol Nsp12 NSP8 P323L mutation Prevent Protein protein-ligand remained Replication RNA RNA polymerase RNA-dependent RNA polymerase RX-3117 SARS-CoV-2 screened selected sequence Sequence analysis stability targeting tested Treatment viral replication wild-type [DOI] 10.1080/07391102.2020.1819882 PMC 바로가기 [Article Type] Article
Genomic chronicle of SARS-CoV-2: a mutational analysis with over 1 million genome sequencesArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] 1 million genomes analysed Analysis average biochemical Coronaviruses COVID-19 cytosine Deamination distribution Evolution Genome genome sequence Genomic analysis information isolate Mutation nucleotide provide reported SARS-CoV-2 SARS-CoV-2 genome single nucleotide variant (SNV) SNV variant Variation virus [DOI] 10.3906/biy-2106-8 PMC 바로가기 [Article Type] Article
Mutational spectrum of SARS-CoV-2 during the global pandemic세계적 대유행 동안 SARS-CoV-2의 돌연변이 스펙트럼Article Published on 2021-08-272022-09-10 Journal: Experimental & Molecular Medicine [Category] MERS, SARS, 변종, [키워드] accumulate Analysis Asia base collected collection time coronavirus COVID-19 pandemic cytosine directional ENhance equilibrium Evidence evidence of Evolution Evolutionary biology exhibit extreme genetic material Genome Genome evolution genome sequence global pandemic guanine help human population information interactions monitoring much higher Mutation mutational processe mutational processes mutational spectrum natural selection nucleic acid predict reached replaced REPLACED BY researcher responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutations SARS-CoV-2 viral infection SARS-CoV-2 virus Science sequence South Korea Spectrum substitutions technology the SARS-CoV-2 genome the SARS-CoV-2 virus Transmission uracil Viral viral genes viral genome sequence viral genome sequences viral infection Viral transmission virus viruses was performed [DOI] 10.1038/s12276-021-00658-z PMC 바로가기 [Article Type] Article
Putative Repurposing of Lamivudine, a Nucleoside/Nucleotide Analogue and Antiretroviral to Improve the Outcome of Cancer and COVID-19 PatientsOncology Published on 2021-07-212022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] 3TC addition analogue anti-SARS-CoV-2 anticancer antiretroviral Antiretrovirals Antiviral Cancer cancer cell carried Cell Chemotherapy Combination COVID-19 COVID-19 pandemic cytidine cytosine docking Effect Effectiveness evaluate Evidence HBV HBV infection hepatitis B HIV HIV positive HIV-1 infection in silico indicated Inflammation inhibit inhibitor lamivudine life-threatening liver Patient patients positive Prevent Radiotherapy RdRP RdRp RNA polymerase receive repurposing RNA polymerase SARS-CoV-2 shown Side effect the SARS-CoV-2 tissues Treatment viral replication virus virus infection [DOI] 10.3389/fonc.2021.664794 PMC 바로가기 [Article Type] Oncology
Genomic epidemiology of SARS-CoV-2 in the UAE reveals novel virus mutation, patterns of co-infection and tissue specific host immune responseUAE에서 SARS-COV-2의 게놈 역학은 새로운 바이러스 돌연변이, 공동 감염 패턴 및 조직 특이 적 숙주 면역 반응을 나타낸다.Article Published on 2021-07-072022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, [키워드] ADAR adenosine APOBEC APOBEC4 Bronchoalveolar lavage fluid clade Co-infection collected conducted COVID-19 epidemic cytosine defined distribution enrichment epidemiological Epidemiology Evolution expression FIVE gene families gene family Genetic variant genetics genomic Host Host immune response host response human-to-human transmission infected patients Infectious diseases innate immune Inosine Interaction knowledge Local molecular Mutation Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharynx pattern provide reported reveal SARS-CoV-2 SARS-CoV-2 evolution Sequencing subclade the SARS-CoV-2 tissue specific Transmission United Arab Emirates upregulation uracil Viral virus was related [DOI] 10.1038/s41598-021-92851-3 PMC 바로가기 [Article Type] Article
AID and APOBECs as Multifaceted Intrinsic Virus-Restricting Factors: Emerging Concepts in the Light of COVID-19AID와 APOBEC를 다면적 고유 바이러스 제한 요인으로: COVID-19에 비추어 볼 때 새로운 개념Immunology Published on 2021-07-012022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] AID AID/APOBECs gene expression signature anatomical antibody production Antiviral antiviral response APOBEC APOBEC4 APOBECs Apolipoprotein B catalytic cell type cell types concept Coronaviruses COVID-19 cytidine Cytidine deaminase cytosine determinant Dissection DNA and RNA driving enzyme expression family members focus gene signature Germinal center highlight Host humoral immune response intrinsic LIGHT lymphoid lymphoid structures master regulator mechanism memory B cells mRNA plasma plethora polymorphism Reactions SARS-CoV-2 Structure subunit the patient uracil variety virus viruses [DOI] 10.3389/fimmu.2021.690416 PMC 바로가기 [Article Type] Immunology