Blood coagulation, risk factors and associated complications in COVID-19 patients in Saudi Arabia: A retrospective cohort study4100 Published on 2023-10-272024-09-05 Journal: Medicine [Category] update2024, [키워드] Coagulopathy COVID-19 D-dimers Mortality Prothrombin time [DOI] 10.1097/MD.0000000000035621 PMC 바로가기 [Article Type] 4100
Extended coagulation profile of children with Long Covid: a prospective studyArticle Published on 2022-11-012022-11-16 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] activated acute SARS-CoV-2 infection Adults age analyzed Antigen Biomarker case-control study change characterized children Coagulation cofactor Cohort control group controls D-dimer level D-dimers Diagnosis eight endothelial damage endotheliopathy enrolled explained Extended females fibrinogen Follow-up FVIII Infection initial International IQR ISARIC Italy Long majority microbiologically no significant difference normalized pediatric plasma profile profiles proportion Prospective Study Prothrombin time respiratory Sample SARS-COV-2 infection Symptom Symptoms the median the SARS-CoV-2 von Willebrand factor vWF [DOI] 10.1038/s41598-022-23168-y PMC 바로가기
Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients입원한 SARS-CoV-2 감염 환자의 조기 퇴원 예측인자로 기준선에서의 임상, 실험실 데이터 및 염증성 바이오마커Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Admission AUC baseline Beta C-reactive protein category CD25 clinical collected Corticosteroid Corticosteroids cytokine Cytokines D-dimers dehydrogenase Determination discharge discharged Factor group help hospital Hospitalization Hospitalized hospitals identify IMPROVE independent Inflammatory Inflammatory biomarker interferon interleukin laboratory data laboratory parameter Lactate lactate dehydrogenase logistic regression models Macrophage Male sex Mild mild patient mild patients Negative predictive value neutrophil NLR not need NPV oxygen oxygen saturation Oxygen therapy Patient performed plasma plasma sample plasma samples Positive predictive value PPV predict Predictive Predictive value predictor pro-inflammatory cytokine pro-inflammatory cytokines Protein receptor Regression model SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 pandemic sensitivity severity Spanish specificity Transmission Treatment variable virus worsening [DOI] 10.1371/journal.pone.0269875 PMC 바로가기 [Article Type] Article
Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected MiceSARS-CoV-2에 감염된 마우스의 폐에서 염증의 사이토카인 및 지질 매개체Article Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Analysis analyzed animal animal model animal models Blood blood clot Blood clots characterized chemokine chemokines circulating clinical manifestation Concentration coronavirus 2 coronavirus disease coronavirus disease 19 correlated COVID-19 Cytokines D-dimer D-dimers different time point different time points elevated ethanolamide event events Features Genes glycerol glycine hallmark highlight histology Human hydroxy indicated Infection Inflammation inflammatory mediator Inflammatory mediators interferons K18-ACE2 knowledge leukocyte leukocyte infiltration Lipid lipid mediator lipid mediators of inflammation lipids lung Lung inflammation lung tissue lung tissues lung viral load Lungs mass spectrometry Measures mediator mice modulation Other Pathogenesis pathology pathophysiological performed PGF plasma Post-infection produced prostaglandin reduced Replication RNA-seq analysis robust SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Support Tandem mass spectrometry therapeutic strategy transcriptomic transgenic mice treat uninfected vasculature viral replication [DOI] 10.3389/fimmu.2022.893792 PMC 바로가기 [Article Type] Article
Association between Coagulation Profile and Clinical Outcome in Children with SARS-CoV-2 Infection or MIS-C: A Multicenter Cross-Sectional StudyArticle Published on 2022-02-172022-10-31 Journal: Children [Category] COVID-19, [키워드] activated Admission affected age Blood children clinical clinical history Clinical outcome Coagulation collected COVID-19 cross-sectional D-dimer D-dimer value D-dimer values D-dimers diagnosed with COVID-19 Diagnosis died enrolled evaluate fibrinogen value higher risk increased risk Infection Inflammatory INR intensive care International IQR Limited management median age MIS-C multicenter multivariate logistic regression normalized outcome Patient pediatric performed Platelet predictor profile retrospective SARS-CoV-2 syndrome the patient the SARS-CoV-2 Univariate analysis [DOI] 10.3390/children9020279 PMC 바로가기 [Article Type] Article
Quadrantanopia as the only symptom of post-COVID stroke in the occipital pole Case report5800 Published on 2021-11-052022-10-30 Journal: Medicine [Category] COVID-19, MERS, [키워드] Brain Case report Complication complications of COVID-19 COVID-19 COVID-19 infection D-dimer D-dimers diagnosed elevated MRI Neuro-ophthalmology neurologic occipital ophthalmic Patient Pneumonia post-COVID-19 patient quadrantanopia risk SARS-CoV-2 stroke Symptom the patient thrombosis thrombotic treated Visual field defect [DOI] 10.1097/MD.0000000000027542 PMC 바로가기 [Article Type] 5800
Could Soluble Endothelial Protein C Receptor Levels Recognize SARS-CoV2-Positive Patients Requiring Hospitalization?가용성 내피 단백질 C 수용체 수준이 입원이 필요한 SARS-CoV2-양성 환자를 인식할 수 있습니까?Observational Study Published on 2021-11-012022-09-11 Journal: Shock (Augusta, Ga.) [Category] MERS, SARS, 바이오마커, 임상, [키워드] 95% CI activated activities activity Admission age an area Analysis Anti-inflammatory Anticoagulant APC BMI characteristic clinical impact Cohort contribute COVID-19 COVID-19 patient COVID-19 patients D-dimers elevated endothelial EPCR Factor Hospital admission Hospitalization hospitalized patient hospitalized patients identify inhibit investigated lead Level multiple logistic regression Multiple logistic regression analysis Outpatient outpatients Pathways Patient patients phenotype plasma point-of-care potential risk Predictive Predictive value prognostic Protein protein C receiver receiver operating characteristic receptor regulate reported ROC ROC Curve Symptoms was performed were measured [DOI] 10.1097/SHK.0000000000001780 PMC 바로가기 [Article Type] Observational Study
Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary EvidenceCOVID-19 관리에서 항바이러스제로서의 락토페린: 예비 증거Article Published on 2021-10-192022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료제, [키워드] added adverse event adverse events Analysis antiviral activity Antiviral effect Asymptomatic Asymptomatic COVID-19 bovine bovine lactoferrin cationic clinical symptom conducted COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients D-dimer D-dimers exocrine gland exocrine glands ferritin glycoprotein healthy subject Hospitalized hospitalized patient IL-6 in vitro in vivo intranasal Isolation lactoferrin liposomal bovine lactoferrin management medication Mild-to-moderate multifunctional Negative conversion Neutrophils observation Patient patients recruited reported SARS-CoV-2 SARS-CoV-2 RNA Serum ferritin significant decrease Standard of care three groups treated [DOI] 10.3390/ijerph182010985 PMC 바로가기 [Article Type] Article
Combined Use of Wells Scores and D-dimer Levels for the Diagnosis of Deep Vein Thrombosis and Pulmonary Embolism in COVID-19: A Retrospective Cohort StudyCardiology Published on 2021-09-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% CI absolute lymphocyte antiplatelet approach assessment benefit Blood urea nitrogen BMI body mass index Cancer Combined Complication coronavirus disease COVID-19 COVID-19 patient COVID-19 patients criteria D-dimer D-dimer level D-dimers deep Deep vein thrombosis diagnose diagnosing Diagnosis DVT Embolism failure Gender intubation Level male material Occurrence outcome Patient patients PE group Platelet positive Prevalence Primary outcome pulmonary Pulmonary embolism Result risk factor score secondary sensitivity severity SOFA specificity statistically significant systemic inflammation Systolic blood pressure Thromboembolism utility Vein VTE WBC well wells dvt score wells pe score [DOI] 10.7759/cureus.17687 PMC 바로가기 [Article Type] Cardiology
Thromboinflammation Supports Complement Activation in Cancer Patients With COVID-19혈소판 염증은 COVID-19에 걸린 암 환자의 보체 활성화를 지원합니다Immunology Published on 2021-08-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] accompanied Activation addition amyloid A analyzed C1-Inhibitor C3a C5a Cancer cancer patient Cancer patients cascade cascades circulating Coagulation complement Complement activation Complement inhibitor complement inhibitors conducted COVID-19 COVID-19 pathology D-dimer D-dimer level D-dimers described disease pathology dysfunction elevated Endothelial cell Endothelial dysfunction evaluate evaluated examined Factor FEU ICAM-1 increase Inflammation Inflammatory response inhibitors marker objective P-selectin Patient plasma platelet activation receptor Result SC5b-9 serum amyloid significantly increased soluble urokinase plasminogen activator receptor stratified Support systemic inflammation Thromboinflammation thrombomodulin Vascular Vascular damage with COVID-19 [DOI] 10.3389/fimmu.2021.716361 PMC 바로가기 [Article Type] Immunology