Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?article Published on 2023-01-182024-09-05 Journal: mBio [Category] update2024, [키워드] ACE2 astrocytes CNS D614G Delta neuroinvasion Neuropathogenesis neurotropism neurovirulence NRP1 omicron SARS-CoV-2 [DOI] 10.1128/mbio.02920-22 PMC 바로가기 [Article Type] article
SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
Heterologous booster with inhaled adenovirus vector COVID-19 vaccine generated more neutralizing antibodies against different SARS-CoV-2 variantsArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition adenoviral vector Adenovirus adenovirus type 5 vector vaccine Anti-RBD IgG booster COVID-19 COVID-19 vaccine D614G demonstrated dose effective Efficacy IgA immunization Inactivated vaccine Inactivated Vaccines Inhaled lack mucosal Neutralization assay Neutralizing neutralizing antibody omicron Omicron variant BA.5 pandemic plasma Protective RBD SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 vaccines SARS-CoV-2 variant subunit titre Vaccination strategies Vaccination strategy Vaccine variant virus widespread [DOI] 10.1080/22221751.2022.2132881 PMC 바로가기
ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
Delta variant (B.1.617.2) of SARS-CoV-2: Mutations, impact, challenges and possible solutionsSARS-CoV-2의 델타 변종(B.1.617.2): 돌연변이, 영향, 과제 및 가능한 솔루션Review Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acquisition Alpha B.1.617.2 Beta Characteristics COVID-19 COVID-19 pandemic Critical D614G Delta delta variant Efficacy effort Evidence Evolution explained immune evasion L452R measure Mutation omicron Omicron variant outbreak Outbreaks P681R reason for S-protein SARS-CoV-2 SARS-CoV-2 variant spike mutation spike mutations T478K the WHO Transmissibility vaccination Vaccine vaccine efficacy VoC [DOI] 10.1080/21645515.2022.2068883 PMC 바로가기 [Article Type] Review
Fully Automated CRISPR-LAMP Platform for SARS-CoV-2 Delta and Omicron VariantsArticle Published on 2022-11-082022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy amplification automated B.1.617.2 Combined CRISPR D614G Delta detect Detection limit diagnostic diagnostic systems IMPROVE limit mutant mutations omicron P681H P681R platform Point mutation RdRP reaction RNA SARS-CoV-2 SARS-CoV-2 strain sensitivity Sensitivity and specificity specificity spike stability T478K variants wild type [DOI] 10.1021/acs.analchem.2c03607 PMC 바로가기
Evaluating correlates of protection for mix-match vaccine against COVID-19 VOCs with potential of evading immunityArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] appear Bayesian Beta ChAdOx1 Clinical efficacy Correlate of protection COVID-19 D614G Delta Delta VOC distribution Efficacy ENhance evaluate Evaluating finding Heterologous highlight homologous Immunity inversion Mix-match mRNA-1273 neutralizing antibody omicron pandemic phase 3 trial predicted Predictive previous study provide ranged reduction reductions in strain vaccination Vaccine variant variant of concern variants variants of concern VoC VOCs was used while Wuhan [DOI] 10.1016/j.vaccine.2022.10.011 PMC 바로가기
Characteristics and Outcomes of Critically Ill Children With Multisystem Inflammatory SyndromeArticle Published on 2022-11-012022-11-16 Journal: Pediatric critical care medicine : a journal of th [Category] SARS, 변종, [키워드] acute respiratory syndrome B.1.1.7 Care children children with MIS-C cohort study coronavirus Critical D614G deaths decrease driving Frequency hospital Ill in viral Inflammatory interquartile range IQR LOS measurement mechanical ventilation median MIS-C Mortality outcome outcomes pediatric predominant Prevalence SARS-CoV-2 SARS-CoV-2 viral significant decrease strain study period syndrome System the disease the median viral strain [DOI] 10.1097/PCC.0000000000003054 PMC 바로가기
In silico characterization of mutations circulating in SARS-CoV-2 structural proteinsArticle Published on 2022-11-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] Algorithm Analysis caused circulating computational approach computational tool COVID-19 D614G death Deleterious discrete molecular dynamics DMD envelope protein full-length identify infections meta-data molecular molecular simulations mutant Mutation mutations N protein Neutral NMA non-structural protein normal mode analysis Nsp3 nucleocapsid nucleocapsid protein pandemic predicted Protein protein coding gene protein stability Proteins RdRP RNA-directed RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence Seven Spike protein stability structural protein suggested utilised viral dynamics viral genome viral pathogenicity [DOI] 10.1080/07391102.2021.1908170 PMC 바로가기
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기