Efficacy of defensins as neutralizing agents against the deadly SARS-CoV-2Article Published on 2023-04-012023-07-08 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] angiotensin-II converting enzyme COVID-19 treatment defensin In-silico study phytochemicals spike-protein [DOI] 10.1080/07391102.2022.2041487
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] acute respiratory syndrome added adjuvant against SARS-CoV Analysis Antigen antigens applied Applying approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin [DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article
Engineering defensin α-helix to produce high-affinity SARS-CoV-2 spike protein binding ligands고친화성 SARS-CoV-2 스파이크 단백질 결합 리간드를 생성하기 위한 디펜신 α-나선 공학Article Published on 2022-06-012022-09-11 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Amino acid amino acid residue amino acid residues angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacterial binding binding ligand blocked class competitive inhibition coronavirus COVID-19 Critical defensin demonstrated diagnostic diagnostics disrupt Disulfide Engineering exceptional expressed expression high-affinity binding homogeneity host cell host cells initial Interaction kDa Ligand ligands Protein protein-protein interaction purified receptor residue SARS-CoV-2 SARS-CoV-2 diagnostics SARS-CoV-2 neutralizing antibodies SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus soluble ACE2 Spike protein spike-protein the SARS-CoV-2 the spike protein therapy viral infection were used α-helix [DOI] 10.1002/pro.4355 PMC 바로가기 [Article Type] Article
Salivary immunity of elite collegiate American football players infected with SARS-CoV-2 normalizes following isolation Research Published on 2022-05-312022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] AMPs average Biomarker changes in characterized complex Concentration Control COVID-19 COVID-19 infection defensin determine Effect General population greater groups Human Immunity infected with SARS-CoV-2 Infection Isolation lactoferrin LL-37 Lung inflammation positive Protein remained risk salivary SARS-CoV-2 secretion t-test tested uninfected were measured were used [DOI] 10.1038/s41598-022-12934-7 [Article Type] Research
Diagnostic and Therapeutic Potential for HNP-1, HBD-1 and HBD-4 in Pregnant Women with COVID-19COVID-19에 감염된 임산부에서 HNP-1, HBD-1 및 HBD-4에 대한 진단 및 치료 가능성Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] affected Alpha AMPs anti-inflammatory cytokine antimicrobial peptide antimicrobial peptides Beta Biochemistry biological activities characterized Coagulation Confirmed COVID-19 infection COVID-19 COVID-19 infection cytokine cytokine profile Cytokines defensin Defensins deficiency defined ELISA assay evaluated fetus Gene Expression generate help highlight IL-10 IL-2 IL-6 IL-8 immune immune system immunological change increase in Infection innate immune system Interleukins involved Laboratory Laboratory medicine lipoprotein lipoprotein-a mechanism mother peptides Potential Pregnancy pregnant women pro-inflammatory factor pro-inflammatory factors problem problems PROTECT risk factor TGF-β TNF-α virus attacks Vitamin vitamins with COVID-19 [DOI] 10.3390/ijms23073450 PMC 바로가기 [Article Type] Article
Evaluation of anti-malaria potency of wild and genetically modified Enterobacter cloacae expressing effector proteins in Anopheles stephensi야생 및 유전자 변형된 Enterobacter cloacae의 항말라리아 효능 평가: Anopheles stephensi에서 효과 단백질 발현Research Published on 2022-02-192024-08-08 Journal: Parasites & Vectors [Category] 말라리아, [키워드] Anopheles stephensi defensin Enterobacter cloacae malaria Paratransgenesis Scorpine [DOI] 10.1186/s13071-022-05183-0 PMC 바로가기 [Article Type] Research
Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design퓨린 억제제로서 COVID-19에 대응하는 ta-Defensins: 인실리코 효율성 예측 및 새로운 화합물 설계Research Article Published on 2022-02-092022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-inflammatory antigenicity antimicrobial peptide antimicrobial peptides arginine bind binding binding site caused Cell cell membrane characterized Compound coronavirus coronavirus disease Coronavirus disease 2019 counter COVID-19 COVID-19 infection Defense defense mechanisms defensin docking docking analysis drug candidate drug candidates Efficiency electrostatic enzyme event furin furin inhibitors Health Organization in silico approaches in vitro in vivo infect Inflammatory inhibit investigated mechanism mechanisms molecules novel pandemic peptide peptides Potential treatment prediction respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein Spike proteins stability Stage subclass the cell the spike protein therapeutic unique WHO World Health Organization [DOI] 10.1155/2022/9735626 PMC 바로가기 [Article Type] Research Article
Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity항바이러스 선천 면역에서 비타민 D 유도 항균 펩티드의 새로운 역할Review Published on 2022-01-112022-09-10 Journal: Nutrients [Category] 유전자 메커니즘, 치료제, [키워드] 25-hydroxyvitamin D active form AMP AMPs antibacterial activity antibacterial immunity antimicrobial antimicrobial peptide antimicrobial peptides antiviral immunity antiviral responses Bacterial binding calcifediol calcitriol CAMP caries Cathelicidin characterized circulating component components contribute coronavirus COVID-19 COVID-19 pandemic cytokine cytokine network Cytokines defensin Dental caries elements etiological agent Evidence Gene Expression Human immune Immune cell immune cells in vitro in vivo increased risk indication induce Infection Innate Innate immune cells Innate immunity LL-37 pathogen Pattern recognition Pattern recognition receptors peptide peptides potential mechanism potential mechanisms provided regulate role SARS-CoV2 secondary structures secretion Signaling stimulated Transcription transcription factor urinary tract infections VDR Viral Vitamin Vitamin D vitamin D deficiency Vitamin D receptor β-defensin [DOI] 10.3390/nu14020284 PMC 바로가기 [Article Type] Review
Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected IndividualsImmunology Published on 2021-11-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] age Ageing analyzed Anti-viral Antiviral Asymptomatic Comorbidities COVID - 19 defensin effective expression expression pattern form forms Gender groups heterogeneous Host identify IFITM1 IFITM3 IFN - interferon IFN-I IFN-α IFN-β IFN-λ1 individual induce infected with SARS-CoV-2 Infection innate immune innate immune response Innate immunity interferon interferon-stimulated gene intrinsic LL-37 Local modulation mRNA expression mRNA level mucosa mucosal mucosal immunity nasopharyngeal nasopharyngeal mucosa Nasopharyngeal swab occur pediatric peptide Primary infection protective role Protein reached SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection selected selective subject subjects susceptibility symptomatic Symptoms the SARS-CoV-2 triggered type I type III upregulated upregulation virus β-defensin [DOI] 10.3389/fimmu.2021.750279 PMC 바로가기 [Article Type] Immunology
Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights From Experimental and Molecular Dynamics Simulations StudiesOriginal Research Published on 2021-10-072024-09-02 Journal: Frontiers in Pharmacology [Category] 대상포진, [키워드] antibiotic antimicrobial peptide (AMP) cathelicidin (LL37) computational simulation defensin drug design host defense (antimicrobial) peptides molecular dynamics simulations [DOI] 10.3389/fphar.2021.731499 PMC 바로가기 [Article Type] Original Research