Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges
Review article
[키워드] coiled-coil-containing protein kinase 1
17β-HSD17β-Hydroxysteroid dehydrogenase specificity
17β-Hydroxysteroid dehydrogenase specificity
3β-HSD3β-Hydroxysteroid dehydrogenase specificity
3β-Hydroxysteroid dehydrogenase specificity
4-Hydroxy-trans-2-NonEnal
8-Oxo-2'-deoxyguanosine
8-Oxo-dG8-Oxo-2'-deoxyguanosine
AAArachidonic acid
ABCATP Binding Cassette
ABCG2ATP-binding cassette superfamily G member 2
active transport
adverse effect
AEadverse effect
ALSAmyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
anthracyclines
arachidonic acid
ATactive transport
ATP Binding Cassette
ATP-binding cassette superfamily G member 2
BCBreast cancer
beta actin
BRAC1breast cancer type 1
Breast
Breast cancer
breast cancer type 1
Cancer
cancer causing genes
Cancer stem cells
cancerous cells
candidate
CCcancerous cells
CCGscancer causing genes
CDKcyclin-dependent kinase
clinical trials
complications
Computational approaches
costly
COX-2Cyclo-oxygenase 2
CSCscancer stem cells
CTsclinical trials
cyclin-dependent kinase
Cyclo-oxygenase 2
DBFdrug binding frequency
DBSdrug binding site
death
Dehydroepiandrosterone
Dehydroepiandrosterone sulfate
DHEADehydroepiandrosterone
DHEASDehydroepiandrosterone sulfate
Di phosphomevalonate decarboxylase
Diabetes Mellitus
DIdrug induced
DMDiabetes mellitus
DNA Topoisomerase II Alpha
DRdrug resistance
drug
drug binding frequency
drug binding site
drug induced
drug resistance
drug transporters
DTsdrug transporters
ECMextra cellular matrix
EHRselectronic health records
Electronic health records
EMTEpithelia-Mesenchymal transition
EP1prostaglandin E2 receptor 1
Epithelia-Mesenchymal transition
ER+Estrogen Receptor-Positive
ERCC2Excision repair cross-complementing group 2
EREsestrogen receptor binding elements
ERestrogen receptor
ERKextracellular signal-regulated kinases
estrogen receptor
estrogen receptor binding elements
Estrogen Receptor-Positive
Excision repair cross-complementing group 2
extra cellular matrix
extracellular signal-regulated kinases
Factors
FAKfocal adhesion kinase
focal adhesion kinase
glutathione S-transferase
Glycogen synthase kinase 3 beta
GSKβGlycogen synthase kinase 3 beta
GSTglutathione S-transferase
H-rasHarvey Rat sarcoma virus
Harvey Rat sarcoma virus
HDHuntington disease
HER1/2Human epidermal growth factor receptor 1/2
HER2-Human Epidermal growth factor receptor 2 negative
HER2+Human Epidermal growth factor receptor 2 positive
HERhuman epidermal growth factor receptor
HMG-CoA reductase
HMG-CoA Synthase
HMGCRHMG-CoA reductase
HMGCSHMG-CoA Synthase
HNE4-Hydroxy-trans-2-NonEnal
HPTHypertension
human epidermal growth factor receptor
Human epidermal growth factor receptor 1/2
Human Epidermal growth factor receptor 2 negative
Human Epidermal growth factor receptor 2 positive
Huntington disease
hypertension
IBDInflammatory bowel disease
IGF-1insulin-like growth factor 1
Inflammatory bowel disease
information
inhibitor
insulin-like growth factor 1
Lanosterol synthase
LHRHluteinizing hormone-releasing hormone
LSSLanosterol synthase
luteinizing hormone-releasing hormone
malignant cells
malondialdehyde
mammalian target of rapamycin
MAPKmitogen- activated protein kinase
matrix metalloproteinase
MCmalignant cells
MDAmalondialdehyde
MDmedian duration
MDRmulti-drug resistance
median duration
membrane transporters
MetAP2methionine aminopeptidase-2
methionine aminopeptidase-2
MHS2MutS Homolog 2
microtubules
mitogen- activated protein kinase
mitoxantrone resistant cells
MLH1MutL homolog 1
MMPmatrix metalloproteinase
molecular mechanism
Mortality
MRCmitoxantrone resistant cells
MTmicrotubules
mTORmammalian target of rapamycin
MTsmembrane transporters
multi-drug resistance
MutL homolog 1
MutS Homolog 2
MVDDi phosphomevalonate decarboxylase
NAD(P)H dehydrogenase [quinone] 1
NCCnon-cancerous cells
NCENew chemical entity
New chemical entity
NF-κBNuclear factor kappa-light-chain-enhancer of activated B cell
Nitric Oxide Synthase 3
non-cancerous cells
Non-profit organisations
non-steroidal anti-inflammatory medicine
NOS3Nitric Oxide Synthase 3
NPONon-profit organisations
NQO1NAD(P)H dehydrogenase [quinone] 1
NSAIDnon-steroidal anti-inflammatory medicine
Nuclear factor kappa-light-chain-enhancer of activated B cell
occur
OCT1organic cation transporter 1
organic cation transporter 1
P-glycoprotein
P-gpP-glycoprotein
p53Tumor protein p53
PEG2/PGH2prostaglandin E2
PR+Progesterone Positive
Progesterone Positive
progesterone receptor
prostaglandin E2
prostaglandin E2 receptor 1
proteomics
provide
PRprogesterone receptor
Rac1Ras-related C3 botulinum toxin substrate 1
Randomised clinical trials
Ras homolog family member A
Ras-related C3 botulinum toxin substrate 1
RCTsRandomised clinical trials
reactive oxygen species
Receptor tyrosine kinase
Repurposed drug
responsible
Rho-ARas homolog family member A
rho-associated
Ribosomal protein S6 kinase
rising
ROCK1rho-associated
ROSreactive oxygen species
RTKReceptor tyrosine kinase
S6KRibosomal protein S6 kinase
Scientific community
SCstromal cells
SCTssolute carrier transporters
selective estrogen receptor degrader
selective estrogen receptor modulator
sequential strategies
SERDselective estrogen receptor degrader
SERM
Side effects
signal transducer and activator of transcription 3
SIRT1/2sirtuin (silent mating type information regulation 2 homolog) ½
sirtuin (silent mating type information regulation 2 homolog) ½
SLC22A16Solute Carrier Family 22 Member 16
SMAD 2/3/4SMAD family member 2/3/4
SMAD family member 2/3/4
Solute Carrier Family 22 Member 16
solute carrier transporters
Sp1/3/4specificity protein 1/3/4
specificity protein 1/3/4
SQLESqualene monooxygenase
Squalene monooxygenase
SSsequential strategies
STAT3signal transducer and activator of transcription 3
stromal cells
subject
survival
TAEtopoisomerase alteration expression
Tamoxifen
TAMTamoxifen
TCtumour cells
TGFαTransforming growth factor-alpha
TGFβ-RITransforming growth factor-beta type 1 receptor
TGFβ1/β2Transforming growth factor beta1/2
TOP2ADNA Topoisomerase II Alpha
topoisomerase alteration expression
TP53tumor protein
Transforming growth factor beta1/2
Transforming growth factor-alpha
Transforming growth factor-beta type 1 receptor
Treatment
treatment-related side effects
TRPtumour resistance profile
TSEtreatment-related side effects
tumor protein
Tumor protein p53
tumour cells
tumour resistance profile
vascular endothelial growth factor
VEGFvascular endothelial growth factor
women
xanthine dehydrogenase
XDHxanthine dehydrogenase
β-actbeta actin
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article