Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispeciesMinireview Published on 2023-12-212024-09-05 Journal: Journal of virology [Category] update2024, [키워드] cancer heterogeneity coronavirus Deletion error threshold mutant spectrum Mutation prion ultra-deep sequencing viral disease control virus complexity [DOI] 10.1128/jvi.01511-23 PMC 바로가기 [Article Type] Minireview
Breakthrough Gastrointestinal COVID-19 and Intrahost Evolution Consequent to Combination Monoclonal Antibody ProphylaxisArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] amino acid change antiviral therapy Breakthrough infection Colon Consequent COVID-19 Deletion furin cleavage site Gastrointestinal gastrointestinal tract Infection intestinal low-dose monoclonal antibody mucosa mucosal nonhuman primates promote Prophylaxis rectal swab Replication rhesus SARS-CoV-2 suboptimal prophylaxis. tissue upper respiratory viral evolution viral replication Viral RNA virus virus stock [DOI] 10.1093/infdis/jiac134 PMC 바로가기
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
Intranasal administration of cold-adapted live-attenuated SARS-CoV-2 candidate vaccine confers protection against SARS-CoV-2Article Published on 2022-10-022022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 진단, [키워드] administration animal model attenuate Attenuated vaccines can be used candidate vaccine cleavage COVID-19 COVID-19 pandemic Deletion elicit examined furin cleavage site furin protease glycoprotein hamster hamsters histopathological Host Immunity Infection lesion motif mucosal neutralizing antibody parental pathogenesis of SARS-CoV-2 polybasic protective immunity proteolytic reduce required robust S1/S2 S1/S2 glycoprotein SARS-CoV-2 sequence Spike protein subsequent suggested unique Vaccine virus wild-type WT SARS-CoV-2 [DOI] 10.1016/j.virusres.2022.198857 PMC 바로가기
Genetic sequencing detected the SARS-CoV-2 delta variant in wastewater a month prior to the first COVID-19 case in Ahmedabad (India)Short communication Published on 2022-10-012022-10-05 Journal: Environmental pollution (Barking, Essex : 1987) [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis analyzed B.1.617.2 circulating circulating variant clinical sample clinically COVID-19 COVID-19 case COVID-19 cases D614G Deletion delta variant detect detection First wave Frequency Genetic genomic Gujarat Health identify India infected individual L452R Lineage majority Mutation P681R SARS-CoV-2 SARS-CoV-2 variant second wave Sequencing Spike protein Surveillance symptomatic patient T19R T478K the SARS-CoV-2 the SARS-CoV-2 genome the spike protein variant variants of concern VOCs wastewater surveillance [DOI] 10.1016/j.envpol.2022.119757 [Article Type] Short communication
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesisArticle Published on 2022-09-132022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] accessory gene Accessory genes accessory protein acute respiratory syndrome Affect Alter both virus cells characterized clinical disease clone contribute coronavirus COVID-19 pandemic Deletion driven by Effect ENhance evade Genome Host in vitro in vivo innate immune mouse Mutation pandemic Pathogenesis persists Protein public health crisis Receptor binding replaced Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 variant shown Signaling spike mutation Spread the spike protein Transmission Vaccine vaccine responses variant variant spike Viral variants virus viruses [DOI] 10.1073/pnas.2204717119 PMC 바로가기
Importance of external quality assessment for SARS-CoV-2 antigen detection during the COVID-19 pandemicCOVID-19 전염병 동안 SARS-CoV-2 항원 검출을 위한 외부 품질 평가의 중요성Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome analysed Antigen antigen test antigen tests approval automated circulating Combination concentrations country COVID-19 COVID-19 pandemic COVID-19 testing dataset datasets Deletion evaluate False negative false negatives Genetic immunoassays Importance in viral inactivated increase in independent Laboratory Lateral mutant Panel participant point-of-care test Quality Quality assurance rapid antigen test Registered Regulatory reported required respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variants sensitivity Severe acute respiratory syndrome shown strain Support Surveillance variants variants of concern Viral viral loads VOCs [DOI] 10.1016/j.jcv.2022.105222 PMC 바로가기 [Article Type] Article
Rapid repeat infection of SARS-CoV-2 by two highly distinct delta-lineage viruses2개의 매우 구별되는 델타 계통 바이러스에 의한 SARS-CoV-2의 빠른 반복 감염Case Reports Published on 2022-09-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitutions change conditions Deletion deletions Delta delta variant genomic had no Health increasingly individual Infection Lineage mutations Patient positive Protective Protein question Rapid Reinfection SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants singular Spike protein the Spike variant virus [DOI] 10.1016/j.diagmicrobio.2022.115747 PMC 바로가기 [Article Type] Case Reports
Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concernArticle Published on 2022-08-302022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료제, [키워드] addition Antiviral antiviral activity assays Beta binding block Cell cell cultures cell types cell-cell fusion cells circulating Coronaviruses Deletion Delta demonstrated fusion inhibitor Gamma inhibit inhibited inhibitor interface investigated lectin lung epithelial membrane fusion monomeric mutant N-acetylglucosamine (GlcNAc) N-glycosylation omicron Prevent Protein pseudotyped SARS-CoV-2 remained Replication replication of SARS-CoV-2 S2 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spike protein SPR subsequent surface plasmon resonance tested the spike protein UDA Urtica variant variants of concern variants of SARS-CoV-2 Vero E6 cell viral replication viral spike protein virus entry viruses Wuhan-Hu-1 [DOI] 10.3389/fcimb.2022.989534 PMC 바로가기